Ethnic Differences in the Inflammatory Response in Systemic Inflammation

Inclusion Criteria: Signed informed consent obtained before any trial-related activities. (Trial activities are any procedure that would not have been performed during normal management of the subject). Men aged >18 and <40 years Normal findings in medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant Exclusion Criteria: Treatment with an investigational drug within three weeks prior to this trial Participation in an LPS trial within the last 6 weeks Hereditary deficiency of protein C or S, or a mutation of FV (Leiden), or any other known abnormality affecting coagulation, fibrinolysis or platelet function History of cardiovascular disease Liver or kidney dysfunction Regular use of medication or alcohol abuse Use of any medication within three weeks prior to the first trial day Symptoms of a clinically relevant illness in the 3 weeks before the first trial day Excessive sporting activities Weight over 95 kg