Effects of Growth Hormone in Chronically Ill Children
Hurler Syndrome, Cerebral Palsy, Juvenile Rheumatoid Arthritis
About this trial
This is an interventional treatment trial for Hurler Syndrome
Eligibility Criteria
Inclusion Criteria: Ages 3-17 years Tanner stages 1-3 Each child must have received adequate nutritional therapy supplied by aggressive oral supplementation, gastrostomy tube, or TPN for at least 1 year prior to enrollment. All children will have been referred for continued poor growth and will be less than the 10th percentile for height compared to age and gender normal values. low IGF-1 level at the time of enrollment (measured in the Endocrine clinic). Chronic illness to be included are Hurler Syndrome (MPS-1) with short stature and muscle wasting, cerebral palsy with muscle wasting, juvenile rheumatoid arthritis with muscle wasting and short stature, Crohn's disease and HIV infection. Exclusion Criteria: previous diagnosis with diabetes, chronic fevers (temp > 101.5) or chronic bacterial infection. substantial change in steroid dosing, or having a formerly steroid negative patient start long-term-steroids (anticipated use greater that 7 days
Sites / Locations
- Children's Medical Center of Dallas