Quantifying Abnormalities in Cortical Activation Associated With Auditory Hallucinations Using Functional Magnetic Resonance Imaging

Inclusion Criteria: Investigators will study subjects who: Are between the ages of 18 and 65. Meet diagnostic criteria for any psychiatric disorder with auditory hallucinations (at least one every 20 minutes) including schizophrenia/schizoaffective disorder OR schizophrenia/schizoaffective disorder without auditory hallucinations. Have been treated with an antipsychotic drug for hallucinations at least three months or are unmedicated Are willing to change their current antipsychotic medication if indicated Are able to provide written consent Normal controls must : Be between the ages of 18 and 65 Not meet the diagnostic criteria for schizophrenia or schizoaffective disorder or other psychiatric disorder involving hallucinations Not currently be treated with an antipsychotic drug Be able to provide written consent Exclusion Criteria: Subjects and normal controls will be excluded from participation if there is: Evidence of non-psychiatric, chronic central nervous system (CNS) disease (such as brain injury or neurological disease) Contraindication to MRI, including prior claustrophobic reaction and severe movement disorder A recent change in menstrual status other than recent changes in oral or implanted contraceptive use (for females) A positive pregnancy result (for females)