Natural History Study of Moles and Suspicious Melanoma
Melanocytic Nevi, Acquired Melanocytic Nevi, Primary Cutaneous Melanoma
About this trial
This is an observational trial for Melanocytic Nevi focused on measuring Suspicious mole, Congenital Nevus, Skin Cancer, Moles, Pigmented lesion, LCMN
Eligibility Criteria
INCLUSION CRITERIA: Infants/Children Must be less than or equal to 5 years. Must have large congenital melanocytic nevus (LCMN, diagnosed clinically or by biopsy) that is greater than 20 cm in any one dimension or that is greater than 8 cm in any one dimension involving the scalp. Must have outside referring physician. OR Adults Must be greater than 18 years. Must have greater than or equal to 100 melanocytic nevi greater than 2 mm in diameter. Must have at least one melanocytic nevus greater than or equal to 4 mm in longest dimension. Can have prior history of cutaneous or ocular malignant melanoma. Must have outside primary physician. OR Adults Must be greater than 18 years. Must have a current pigmented lesion clinically suspicious for primary melanoma. Must have outside primary physician. AND All patients, or in the case of infants and children their parents or legal guardians, must be able to understand and sign an informed consent. EXCLUSION CRITERIA: The patient does not meet the inclusion criteria. Diagnosis of genetic syndrome associated with multiple lentigines or nevi (Peutz-Jeghers syndrome, Carney complex, turner syndrome, Noonan's syndrome). Two or more first-degree relatives with history of cutaneous melanoma and familial atypical mole-melanoma syndrome phenotype. Diagnosis of cancer-associated syndrome (xeroderma pigmentosum, type I neurofibromatosis, Li-Fraumeni syndrome). Inability to tolerate surgical procedure due to bleeding diathesis or disorder or other cause as determined by principal investigator. Patient is unwilling to consider elective biopsy of a melanocytic nevus.
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike