Study of Weekly Motexafin Gadolinium (MGd) for Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Inclusion Criteria: ≥ 18 years old CLL as defined by the NCI 96 criteria (exception; patients may have bright surface immunoglobulin staining if negative for t[11;14] translocation or cyclin D1) or SLL as defined by WHO classification criteria and is refractory or relapsed as defined by one of the following: Refractory disease: progressive disease while on therapy Relapsed disease: progressive disease after at least one treatment course of therapy with disease response or stabilization ECOG performance status score of 0, 1, or 2 Willing and able to provide written informed consent Exclusion Criteria: Laboratory values of: Platelet count < 30,000/µL AST or ALT > 2 x ULN (upper limit of normal) Total bilirubin > 2 x ULN Creatinine > 2 mg/dL Chemotherapy, radiation therapy, immunotherapy, systemic corticosteroids (> 10 mg oral prednisone or equivalent), or systemic biologic anticancer therapy within 21 days before beginning study treatment Major surgery or hospitalization for a serious illness within the last 3 months Greater than three prior regimens (where a regimen is defined as a treatment for CLL/SLL given initially or after disease progression) Prior malignancy requiring current or prior treatment within the past 5 years, except for cervical neoplasia in situ and non-melanomatous skin cancer Uncontrolled hypertension