Back to resultsRituximab and Combination Chemotherapy in Treating Older Patients With Previously Untreated B-Cell Lymphoma
Primary Purpose
Lymphoma
Status
Completed
Phase
Phase 2
Locations
International
Study Type
Interventional
Intervention
pegfilgrastim
rituximab
cyclophosphamide
doxorubicin hydrochloride
prednisone
vincristine sulfate
pharmacological study
radiation therapy
Sponsored by
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring contiguous stage II adult diffuse large cell lymphoma, noncontiguous stage II adult diffuse large cell lymphoma, stage I adult diffuse large cell lymphoma, stage III adult diffuse large cell lymphoma, stage IV adult diffuse large cell lymphoma, contiguous stage II adult immunoblastic large cell lymphoma, noncontiguous stage II adult immunoblastic large cell lymphoma, stage I adult immunoblastic large cell lymphoma, stage III adult immunoblastic large cell lymphoma, stage IV adult immunoblastic large cell lymphoma, contiguous stage II adult Burkitt lymphoma, noncontiguous stage II adult Burkitt lymphoma, stage I adult Burkitt lymphoma, stage III adult Burkitt lymphoma, stage IV adult Burkitt lymphoma, contiguous stage II adult diffuse mixed cell lymphoma, noncontiguous stage II adult diffuse mixed cell lymphoma, stage I adult diffuse mixed cell lymphoma, stage III adult diffuse mixed cell lymphoma, stage IV adult diffuse mixed cell lymphoma, contiguous stage II adult diffuse small cleaved cell lymphoma, noncontiguous stage II adult diffuse small cleaved cell lymphoma, stage I adult diffuse small cleaved cell lymphoma, stage III adult diffuse small cleaved cell lymphoma, stage IV adult diffuse small cleaved cell lymphoma, contiguous stage II grade 1 follicular lymphoma, contiguous stage II grade 2 follicular lymphoma, contiguous stage II grade 3 follicular lymphoma, noncontiguous stage II grade 1 follicular lymphoma, noncontiguous stage II grade 2 follicular lymphoma, noncontiguous stage II grade 3 follicular lymphoma, stage I grade 1 follicular lymphoma, stage I grade 2 follicular lymphoma, stage I grade 3 follicular lymphoma, stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histological diagnosis of aggressive B-cell lymphoma Previously untreated disease Stage I-IV disease CD20-positive disease Any International Prognostic Index (IPI) score No secondary lymphoma after prior chemotherapy or radiotherapy No primary CNS lymphoma No primary gastrointestinal (MALT) lymphoma PATIENT CHARACTERISTICS: ECOG performance status 0-2 Life expectancy ≥ 3 months AST and ALT ≤ 3 times normal unless related to lymphoma Bilirubin ≤ 2 mg/dL unless related to lymphoma Creatinine ≤ 2 times normal unless related to lymphoma Fertile patients must use effective contraception No known allergic reactions against foreign proteins No active infections requiring systemically administered antibiotics or antiviral medications No noncompensated heart failure No dilatative cardiomyopathy No coronary heart disease with ST-segment depression in ECG No myocardial infarction during the past 6 months No chronic lung disease with hypoxemia No severe noncompensated hypertension No severe noncompensated diabetes mellitus No clinical signs of cerebral dysfunction No severe psychiatric disease No known HIV infection No active chronic hepatitis B or C infection No other concurrent diseases that exclude the administration of therapy as outlined by the study protocol PRIOR CONCURRENT THERAPY: See Disease Characteristics More than 12 weeks since prior clinical trial participation No prior participation in this study No prior therapy, including murine antibody, for this cancer No prior organ transplantation No concurrent response-adapted radiotherapy ("iceberg radiotherapy") No other concurrent anticancer chemotherapy or other study medication
Sites / Locations
- University Hospital Brno
- Charles University Hospital
- Hopital Debrousse
- Haematologisch Onkologische Praxis
- Ostalb-Klinikum Aalen
- Klinikum St. Marien
- Gemeinschaftspraxis Fuer Innere Medizin, Haematologie Und Internistische Onkologie
- Specialist Practice for Oncology
- II. Medizinische Klinik
- Haematologische Praxis
- Hamatologische/Onkologische Gemeinschaftspraxis - Augsburg
- Klinikum Augsburg
- Kreiskrankenhaus Aurich
- Regional Hospital Bad Hersfeld
- HELIOS Klinikum Bad Saarow
- Internistische Praxis - Bad Salzuflen
- Onkologische Schwerpunktpraxis und Tagesklinik Dres
- Kreiskrankenhaus Bad Saeckingen
- Ermstalklinik Bad Urach
- Klinikum am Bamberg
- Krankenhaus Hohe Warte Mediziniche Klinik
- Klinikum Bayreuth
- Praxis Dr. med. Stefan Korsten
- Onkologisches Versorgungszentrum Friedrichshain
- DRK Kliniken Berlin - Koepenick
- Internistische Gemeinschaftspraxis - Berlin
- Haematologisch-Onkologische Schwerpunktpraxis
- Evang. Waldkrankenhaus Spandau
- Internistische Gemeinschaftspraxis - Berlin
- Charite - Campus Charite Mitte
- Onkolog - Haematolog Schwerpunktpraxis
- Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin
- Vivantes Klinikum Neukoelln
- Robert Roessle Comprehensive Cancer Center - Charite Campus Buch
- Hospital Complex Bernburg
- Franziskus Hospital
- Krankenhaus Bietigheim
- Saint Agnes Hospital
- Augusta-Kranken-Anstalt gGmbH
- St. Josef-Hospital - Bochum
- Knappschaftskrankenhaus Bochum-Langendreer
- Johanniter-Krankenhaus Bonn
- Universitaetsklinikum Bonn
- Medizinische Poliklinik
- Praxis fuer Haematologie und Internistische Onkologie - Borken
- Knappschaftskrankenhaus Bottrop
- Hamatologische Sprechstunde
- Staedtisches Klinikum Braunschweig
- Praxis Dres. F.& G. Doering
- Klinikum Bremen-Mitte
- DIAKO Ev. Diakonie Krankenhaus gGmbH
- St. Joseph Hospital
- Zentralkrankenhaus
- Praxis fuer Haematologie und Onkologie - Burgwedel
- Medizinische Klinik am Lukas - Krankenhaus
- General Hospital
- Onkologische Schwerpunktpraxis Celle
- Hospital Kuchwald Chemnitz
- Klinikum Coburg
- Internistische Praxis - Coesfeld
- Lung Clinic Cologne-Merheim
- Praxis Internistischer Onkologie und Haematologie - Koeln
- Kliniken der Stadt Koeln gGmbH - Krankenhaus Holweide
- Praxis fuer Onkologie - Kalk
- Praxis Fuer Haematologie Internistische Onkologie
- Medizinische Universitaetsklinik I at the University of Cologne
- Carl - Thiem - Klinkum Cottbus
- Praxis Dr. Rheinhold Siegmund - Dr. Matthias Penke
- Klinikum Darmstadt
- Staedtisches Klinikum Dessau
- Internistische Praxis
- Saint Johannes Hospital Dortmund
- Klinikum Dortmund
- Universitatsklinikum Carl Gustav Carus
- Universitaetsklinikum Duesseldorf
- Johanniter-Krankenhaus Rheinhausen GmbH
- St. Johannes Hospital - Medical Klinik II
- Franz Hospital Dulmen
- Florence-Nightingale-Krankenhause, Deaconess Kaiserswerth
- Klinikum Barnim GmbH, Werner Forssmann Krankenhaus
- Virngrund-Klinik Ellwangen
- Hans - Susemihl - Krankenhaus
- Helios Klinikum Erfurt
- Medizinische Klinik III - Universitaetsklinikum Erlangen
- St. Antonius Hospital
- Universitaetsklinikum Essen
- Evangelisches Krankenhaus Essen Werden
- Staedtische Kliniken Esslingen
- Schwerpunktpraxis fuer Haematologie und Onkologie - Flensburg
- Gemeinschaftspraxis fuer Internistische - Frankenthal
- Klinikum Frankfurt (Oder) GmbH
- St. Marienkrankenhaus - Frankfurt am Main
- Onkologie Bethanien
- Krankenhaus Nordwest
- Klinikum der J.W. Goethe Universitaet
- Praxis Internistischer Onkologie und Haematologie - Frechen
- Gemeinschaftspraxis - Freiburg
- Evang. Deaconess Hospital Freiburg
- Praxis fur Interdisziplinaere Onkologie
- Universitaetsklinikum Freiburg
- Municipal Hospital Complex
- Klinikum Garmisch - Partenkirchen GmbH
- Robert - Koch Hospital
- Saint Josef Hospital
- Internistische Praxisgemeinschaft
- Centre for Internal Medicine Giessen
- Gemeinschaftspraxis Fuer Innere Medizin, Hematologie Und Onkologie
- Wilhelm-Anton-Hospital gGmbH, Goch
- DR Herbert - Nieper Krankenhaus Goslar
- Klinik Fuer Innere Medizin, Hematology/Oncology, Ernst Moritz Armdt Universitaet
- Kreiskrankenhaus Gummersbach GMBH
- Internistisch-Haematologische Gemeinschaftspraxis - Gustrow
- Staedtisches Klinikum Görlitz GmbH
- Universitaetsklinikum Göttingen
- Staedtisches Klinikum Gütersloh
- Allgemeines Krankenhaus Hagen
- St. Marien Hospital - Katholisches Krankenhaus Hagen gGmbH
- St. Salvator Krankenhaus
- Internistische Gemeinschaftspraxis - Halle
- Universitaetsklinikum Halle
- Krankenhaus St. Elisabeth und St. Barbara
- Krankenhaus Martha-Maria Halle-Doelau gGmbH
- St. Sixtus Hospital
- Praxis fuer Innere Medizin - Bergedorf
- Marienkrankenhaus
- Allgemeines Krankenhaus Altona
- Onkologische Schwerpunktpraxis Dr. med. Verpoort, PD Dr. med. Zeller and Dr. med. Wierecky
- Asklepios Klinik St. Georg
- University Medical Center Hamburg - Eppendorf
- Asklepios Klinik Nord Heidberg
- Haematologisch-Onkologische Praxis Altona
- St. Marien Hospital
- Evangelische Krankenhaus Hamm
- Klinikum Stadt Hanau
- Schwerpunktpraxis Haematologie/Onkologie - Hannover
- Krankenhaus Siloah - Medizinische Klinik II
- Henriettenstiftung Frauenklinik
- Medizinische Hochschule Hannover
- Oncology Specialists Clinic
- Ruprecht - Karls - Universitaet Heidelberg
- Thoraxklinik Heidelberg
- Regional Hospital Heidenheim
- Regional Hospital Am Plattenwald Bad Friedrichshall
- Klinikum Herford
- Marienhospital at Ruhr University Bochum
- Privatklinik Dr. R. Schindlbeck GmbH & Co. KG
- Onkologische Schwerpunktpraxis
- St. Bernward Krankenhaus
- Staedtisches Krankenhaus Hildesheim
- Evang. Hospital
- Haematologie und Internistische Onkologie Praxis
- Universitaetsklinikum des Saarlandes
- Hospital Complex Hoyerswerda
- Clinic for Bone Marrow Transplantation and Hematology and Oncology
- Internistische Gemeinschaftspraxis - Jena
- Klinikum der Friedrich-Schiller Universitaet Jena
- Onkologische Gemeinschaftspraxis - Kaiserslautern
- Westpfalz-Klinikum GmbH
- Staedtisches Klinikum Karlsruhe gGmbH
- St. Vincentius - Kliniken
- Red Cross Hospital Kassel
- Internistische Gemeinschaftspraxis - Kassel
- Klinikum Kempten Oberallgaeu
- Staedtisches Krankenhaus Kiel
- Praxis fuer Haematologie und Onkologie
- Stiftungsklinikum Mittelrhein - Gesundheitszentrum Evangelisches Stift Sankt Martin Koblenz gGmbH
- Leonardis Clinic
- Haematologische / Onkologische Schwerpunktpraxis
- Klinikum Krefeld GmbH
- Internistische Onkologische Praxis - Kronach
- Frankenwald Klinik
- Internistische Praxis - Landshut
- Klinikum Landshut
- Caritas - Krakenhaus Lebach
- Onkologische Schwerpunktpraxis - Leer
- Praxis fuer Onkologie am Diakonissenhaus
- Forschungsgesellschaft mbH
- Gemeinschaftspraxis fuer Dres. Aldaoud und Schwarzer
- University Leipzig Clinic of Internal Medicine
- Klinikum "St. Georg" Leipzig
- Klinikum Lippe - Lemgo
- St. Vincenz Hospital Limburg
- St. Bonifatius Hospital Lingen
- Dreifaltigkeits Hospital
- Kreiskrankenhaus Loerrach
- Onkologische Schwerpunktpraxis
- Klinikum Ludwigsburg
- Klinikum der Stadt Ludwigshafen am Rhein
- St. Marien Hospital Ludwighafen
- Schwerpunktpraxis fuer Haematologie und Onkologie - Luebeck
- Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
- Sana Kliniken Luebeck
- Kreiskrankenhaus Luedenscheid
- Universitatsklinikum der MA
- Staedtisches Klinikum Magdeburg - Altstadt
- Internistische Gemeinschaftspraxis - Magdeburg
- St. Vincenz und Elisabeth Hospital
- Johannes Gutenberg University
- Gemeinschaftspraxis
- III Medizinische Klinik Mannheim
- Schwerpunktpraxis Internist Onkologie - Marburg
- Universitaetsklinikum Giessen und Marburg GmbH - Marburg
- Regional Hospital Mayen
- Gemeinschaftspraxis Dres. med. Ellbrueck/Goeller/Kraenzle/Niedermeier/Jocham
- Krankenhaus Ludmillenstift
- Gemeinschaftspraxis - Minden
- Klinikum Minden
- Krankenhaus Maria Hilf GmbH
- Haematologische Praxis - Moenchengladbach
- Ev. Hospital Bethesda
- Evangelisches Krankenhaus - Muelheim
- St. Marien Hospital - Muelheim an der Ruhr
- Gemeinschaftspraxis - Muenster
- Haematologisch - Onkologische Gemeinschaftspraxis - Muenster
- Klinik und Poliklinik fuer Kinder und Jugendmedizin - Universitaetsklinikum Muenster
- Universitaets - Kinderpoliklinik
- Krankenhaus Muenchen Schwabing
- Munich Oncologic Practice at Elisenhof
- Klinikum der Universitaet Muenchen - Grosshadern Campus
- Staedtisches Krankenhaus Muenchen - Harlaching
- Klinikum Rechts Der Isar - Technische Universitaet Muenchen
- Municipal Hospital Munich
- Klinikum Schwaebisch Gmuend Stauferklinik
- Kreiskrankenhaus Muenchberg
- Staedtisches Krankenhaus Nettetal GmbH
- Klinikum Neubrandenburg
- Onkologische Schwerwpunktpraxis Dr. Ladda
- Regional Hospital Neumarkt
- Onkologische Schwerpunktpraxis Dr. Schmidt
- Staedtisches Klinikum Neunkirchen gGmbH
- Internistische Praxis - Neuss
- Lukaskrankenhaus Neuss
- DRK Krankenhaus Neuwied
- Praxis fuer Haematologie und Interne Onkologie
- Gemeinschaftspraxis fuer Onkologie - Nordhorn
- Gemeinschaftspraxis fuer Haematologie - Northeim
- Praxisklinik fuer Innere Medizin - Nuernberg
- Klinikum Nuernberg - Klinikum Nord
- Schlossbergkliniken Oberstaufen
- Internistische Gemeinschaftspraxis - Offenbach
- Klinikum Offenburg
- Pius Hospital - Oldenburg
- Internistische Gemeinschaftspraxis - Oldenburg
- Ev. Hospital Oldenburg
- Klinikum Oldenburg
- St. Martinus Hospital - Olpe
- Marien Hospital
- Klinikum Osnabrück GmbH
- Paracelsus - Klinik Osnabrück
- Bruederkrankenhaus St. Josef Paderborn
- Asklepios Klinik - Parchim
- Staedtisches Krankenhaus
- Krankenhaus Siloah - Pforzheim
- Praxis fuer Innere Medizin am Krankenhaus Siloah - Pforzheim
- Gemeinschaftspraxis - Pinneberg
- Klinikum Ernst Von Bergmann
- Kreiskrankenhaus Radebeul
- Gemeinschaftspraxis - Ravensburg
- Krankenhaus St. Elisabeth - Ravensburg
- Elisabeth Krankenhaus
- Prosper-Hospital Recklinghausen
- Hematologische Onkologische Praxis
- Klinikum der Universitaet Regensburg
- Krankenhaus Barmherzige Brueder Regensburg
- Internistische Praxis Dres. Hempel und Hochdorfer
- Klinikum Remscheid GmbH
- Jakobi Krankenhaus
- Haematologische/Onkologische Schwerpunktpraxis - Rostock
- Klinik und Poliklinik fuer Innere Medizin - Universitaet Rostock
- Klinikum Suedstadt Rostock
- Diakonie - Krankenhaus
- Internistische Schwerpunktpraxis
- Caritasklinik St. Theresia
- Gemeinschaftspraxis - Saarbruecken
- St. Elizabeth-Klinik Saarlouis
- Martin - Luther Hospital
- Praxis fur Innere Medizin - Schmiedeberg
- Deaconess Hospital
- Gemeinschaftspraxis fuer Haematologie und Internist - Schweinfurt
- Leopoldina - Krankenhaus
- HELIOS Klinikum - Schwelm
- Klinikum Schwerin
- St. Marien - Krankenhaus Siegen GMBH
- Evang. Jung-Stilling Hospital
- St. Lukas - Clinic Solingen
- Krankenhaus Maria-Hilf - Stadtlohn
- Onkologische Schwerpunktpraxis - Straubing
- Hospital Bad Cannstatt
- Haematologische Praxis
- Klinik fuer Onkologie - Katharinenhospital Stuttgart
- Diakonie Klinikum Stuttgart
- Gastroenterologische und Haematologisch-Onkologische Praxis E. M. Dr. Hoering von Ehr Respondek
- Klinikum Stuttgart - Buergerhospital
- Robert-Bosch-Krankenhaus
- St. Elisabeth Hospital Thuine
- Regional Hospital Traunstein
- Onkologische Gemeinschaftspraxis - Trier
- Krankenanstalt Mutterhaus der Borromaerinnen
- Krankenhaus Der Barmherzigen Brueder
- Praxis Fuer Internistische Haematologie / Onkologie
- Universitaetsklinikum Tuebingen
- Hospital Tutzing
- Praxis fuer Haematologie und Onkologie
- Comprehensive Cancer Center Ulm at Universitaetsklinikum Ulm
- Ev. Hospital Unna
- St. Marienhospital - Vechta
- Municipal Hospital Complex
- Onkologische Schwerpunktpraxis - Villingen
- Regional Hospital Waldbrol
- Haematologische Praxis
- Gemeinschaftspraxis feur Haemotologie und Onkologie - Weilheim
- Sophien - und Hufeland - Klinikum Weimar gGmbH
- Onkologische Schwerpunktpraxis
- Harz-Klinikum Wernigerode-Blankenburg GmbH
- Asklepios Nordseeklinik Westerland GmbH
- Ammerland-Klinik GmbH
- Hospital Wetzler
- Deutsche Klinik fuer Diagnostik
- Dr. Horst-Schmidt-Kliniken
- Evangelisches Krankenhaus - Lutherstadt Wittenberg
- Ev. Hospital Witten-Herdecke
- Klinikum der Stadt Wolfsburg
- Burkhard and Reimann Gemeinschaftspraxis
- Medizinische Poliklinik, Universitaet Wuerzburg
- Kliniken St. Antonius
- Helios Kliniken Wuppertal University Hospital
- Heinrich-Braun-Krankenhaus Zwickau
- Azienda Ospedaliera di Padova
- Erasmus MC - Sophia Children's Hospital
- Akademia Medyczna im. Piastow Slaskich
- Goeteborg University
- Kantonsspital Aarau
- Universitaets-Kinderspital beider Basel
- Ospedale "la Carita", Locarno
- Kinderspital Luzern
- Ostschweizer Kinderspital
- University Children's Hospital
- Royal Manchester Children's Hospital
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Active Comparator
Arm Label
Interventional: CHOP-14 + 8 x 2-weekly rituximab
Interventional: CHOP-14 + 8 x dose-dense rituximab
Arm Description
Arm I (2-weekly rituximab): Patients receive rituximab IV 375 mg/m^2 (females) and 500 mg/m^2 (males) over 4 hours on days 0, 14, 28, 42, 56, 70, 84, and 98. Patients also receive pegfilgrastim subcutaneously on day 4 of each course.
Arm II (pharmacokinetic-based dose-dense rituximab): Patients receive rituximab IV 375 mg/m^2 (females) and 500 mg/m^2 (males) over 4 hours on days -1, 0, 3, 7, 14, 21, 28, and 42. Patients also receive pegfilgrastim subcutaneously on day 4 of each course.
Outcomes
Primary Outcome Measures
Pharmacokinetics (in first 20 patients of each cohort with a distinct variation of the rituximab schedule) assessed on days -4, -1, 10, 29, 57, 99, 155, 239, 267, 295, 407, and 491 of treatment
Safety and treatment related deaths at 3 months after study completion
Toxicity assessed by NCI criteria, adverse events, serious adverse events, protocol adherence, and treatment-related deaths at 3 months after study completion
Secondary Outcome Measures
Time to treatment failure assessed at 2 years within the study and periodically thereafter
Complete response rate assessed at 2 years within the study and periodically thereafter
Progression rate
Survival time
Progression-free survival
Full Information
NCT ID
NCT00290667
First Posted
February 9, 2006
Last Updated
May 14, 2021
Sponsor
German High-Grade Non-Hodgkin's Lymphoma Study Group
1. Study Identification
Unique Protocol Identification Number
NCT00290667
Brief Title
Rituximab and Combination Chemotherapy in Treating Older Patients With Previously Untreated B-Cell Lymphoma
Official Title
2-Weekly CHOP Chemotherapy With Dose-Dense Rituximab for the Treatment of Patients Aged 61 to 80 Years With Aggressive CD-20 Positive B-Cell Lymphomas: A Phase-II/Pharmacokinetic Study (CHOP-R-ESC)
Study Type
Interventional
2. Study Status
Record Verification Date
May 2021
Overall Recruitment Status
Completed
Study Start Date
February 2004 (undefined)
Primary Completion Date
December 2013 (Actual)
Study Completion Date
November 2015 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
German High-Grade Non-Hodgkin's Lymphoma Study Group
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and kill them or carry cancer-killing substances to them. Others interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, vincristine, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving rituximab together with combination chemotherapy may kill more cancer cells.
PURPOSE: This phase II trial is studying how well giving rituximab together with combination chemotherapy works in treating older patients with previously untreated B-cell lymphoma.
Detailed Description
OBJECTIVES:
Primary
Determine a pharmacokinetic profile for pharmacokinetics-based or rituximab within a CHOP-14 regimen comprising cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone in elderly patients with previously untreated aggressive B-cell lymphoma.
To determine whether increased single-doses of rituximab for males can compensate their lower serum levels.
Evaluate the safety and toxicity profile of this regimen in male patients.
Secondary
Determine the rate of complete responses, primary progressions under therapy, event-free survival, progression-free survival, and overall survival in patients treated with this regimen.
Determine the rate of primary progression in patients treated with this regimen.
OUTLINE: This is a multicenter study. All patients undergo the following treatment.
Prephase treatment: Patients receive vincristine subcutaneously on day -6 and oral prednisone on days -6 to 0.
Immunochemotherapy and radiotherapy: Patients receive CHOP chemotherapy comprising cyclophosphamide IV over 15 minutes, doxorubicin hydrochloride IV, and vincristine IV on day 1 and oral prednisone once daily on days 1-5. Patients also receive pegfilgrastim subcutaneously on days 4, 18, 32, 46, 60, and 74. Treatment with CHOP chemotherapy repeats every 14 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients who show no response after course 4 of CHOP chemotherapy proceed to salvage chemotherapy off study.
Patients are evaluated 2-4 weeks after completion of CHOP. Patients with initial bulky disease (i.e., diameter ≥ 7.5 cm) or extranodal involvement AND achieving complete remission (CR), unconfirmed CR (CRu), or partial remission undergo radiotherapy 5 days a week for 4 weeks. Patients who do not achieve CR or CRu 2 months after completion of radiotherapy proceed to salvage chemotherapy off study.
Patients are then stratified according to center, International Prognostic Index (1-2 vs 3-5), disease involvement (bulky vs extranodal vs bulky and/or extranodal), age (61-70 years old vs 71-80 years old), and gender. Patients are randomized to 1 of 2 treatment arms.
Arm I (2-weekly rituximab): Patients receive rituximab IV 375 mg/m^2 (females) and 500 mg/m^2 (males) over 4 hours on days 0, 14, 28, 42, 56, 70, 84, and 98. Patients also receive pegfilgrastim subcutaneously on day 4 of each course.
Arm II (pharmacokinetic-based dose-dense rituximab): Patients receive rituximab IV 375 mg/m^2 (females) and 500 mg/m^2 (males) over 4 hours on days -1, 0, 3, 7, 14, 21, 28, and 42. Patients also receive pegfilgrastim subcutaneously on day 4 of each course.
Some patients undergo blood sample collection periodically during and after treatment for pharmacokinetic studies.
After completion of study treatment, patients are followed every 3 months for 2 years, every 6 months for 3 years, and then once a year therafter.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Lymphoma
Keywords
contiguous stage II adult diffuse large cell lymphoma, noncontiguous stage II adult diffuse large cell lymphoma, stage I adult diffuse large cell lymphoma, stage III adult diffuse large cell lymphoma, stage IV adult diffuse large cell lymphoma, contiguous stage II adult immunoblastic large cell lymphoma, noncontiguous stage II adult immunoblastic large cell lymphoma, stage I adult immunoblastic large cell lymphoma, stage III adult immunoblastic large cell lymphoma, stage IV adult immunoblastic large cell lymphoma, contiguous stage II adult Burkitt lymphoma, noncontiguous stage II adult Burkitt lymphoma, stage I adult Burkitt lymphoma, stage III adult Burkitt lymphoma, stage IV adult Burkitt lymphoma, contiguous stage II adult diffuse mixed cell lymphoma, noncontiguous stage II adult diffuse mixed cell lymphoma, stage I adult diffuse mixed cell lymphoma, stage III adult diffuse mixed cell lymphoma, stage IV adult diffuse mixed cell lymphoma, contiguous stage II adult diffuse small cleaved cell lymphoma, noncontiguous stage II adult diffuse small cleaved cell lymphoma, stage I adult diffuse small cleaved cell lymphoma, stage III adult diffuse small cleaved cell lymphoma, stage IV adult diffuse small cleaved cell lymphoma, contiguous stage II grade 1 follicular lymphoma, contiguous stage II grade 2 follicular lymphoma, contiguous stage II grade 3 follicular lymphoma, noncontiguous stage II grade 1 follicular lymphoma, noncontiguous stage II grade 2 follicular lymphoma, noncontiguous stage II grade 3 follicular lymphoma, stage I grade 1 follicular lymphoma, stage I grade 2 follicular lymphoma, stage I grade 3 follicular lymphoma, stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 2
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
586 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Interventional: CHOP-14 + 8 x 2-weekly rituximab
Arm Type
Active Comparator
Arm Description
Arm I (2-weekly rituximab): Patients receive rituximab IV 375 mg/m^2 (females) and 500 mg/m^2 (males) over 4 hours on days 0, 14, 28, 42, 56, 70, 84, and 98. Patients also receive pegfilgrastim subcutaneously on day 4 of each course.
Arm Title
Interventional: CHOP-14 + 8 x dose-dense rituximab
Arm Type
Active Comparator
Arm Description
Arm II (pharmacokinetic-based dose-dense rituximab): Patients receive rituximab IV 375 mg/m^2 (females) and 500 mg/m^2 (males) over 4 hours on days -1, 0, 3, 7, 14, 21, 28, and 42. Patients also receive pegfilgrastim subcutaneously on day 4 of each course.
Intervention Type
Biological
Intervention Name(s)
pegfilgrastim
Intervention Type
Biological
Intervention Name(s)
rituximab
Intervention Type
Drug
Intervention Name(s)
cyclophosphamide
Intervention Type
Drug
Intervention Name(s)
doxorubicin hydrochloride
Intervention Type
Drug
Intervention Name(s)
prednisone
Intervention Type
Drug
Intervention Name(s)
vincristine sulfate
Intervention Type
Other
Intervention Name(s)
pharmacological study
Intervention Type
Radiation
Intervention Name(s)
radiation therapy
Primary Outcome Measure Information:
Title
Pharmacokinetics (in first 20 patients of each cohort with a distinct variation of the rituximab schedule) assessed on days -4, -1, 10, 29, 57, 99, 155, 239, 267, 295, 407, and 491 of treatment
Time Frame
-4 to 491 days of treatment
Title
Safety and treatment related deaths at 3 months after study completion
Time Frame
3 months after study completion
Title
Toxicity assessed by NCI criteria, adverse events, serious adverse events, protocol adherence, and treatment-related deaths at 3 months after study completion
Time Frame
3 months after study completion
Secondary Outcome Measure Information:
Title
Time to treatment failure assessed at 2 years within the study and periodically thereafter
Time Frame
at 2 years within the study and periodically thereafterlif
Title
Complete response rate assessed at 2 years within the study and periodically thereafter
Time Frame
at 2 years within the study and periodically thereafter
Title
Progression rate
Time Frame
life-long
Title
Survival time
Time Frame
life-long
Title
Progression-free survival
Time Frame
life-long
10. Eligibility
Sex
All
Minimum Age & Unit of Time
61 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS:
Histological diagnosis of aggressive B-cell lymphoma
Previously untreated disease
Stage I-IV disease
CD20-positive disease
Any International Prognostic Index (IPI) score
No secondary lymphoma after prior chemotherapy or radiotherapy
No primary CNS lymphoma
No primary gastrointestinal (MALT) lymphoma
PATIENT CHARACTERISTICS:
ECOG performance status 0-2
Life expectancy ≥ 3 months
AST and ALT ≤ 3 times normal unless related to lymphoma
Bilirubin ≤ 2 mg/dL unless related to lymphoma
Creatinine ≤ 2 times normal unless related to lymphoma
Fertile patients must use effective contraception
No known allergic reactions against foreign proteins
No active infections requiring systemically administered antibiotics or antiviral medications
No noncompensated heart failure
No dilatative cardiomyopathy
No coronary heart disease with ST-segment depression in ECG
No myocardial infarction during the past 6 months
No chronic lung disease with hypoxemia
No severe noncompensated hypertension
No severe noncompensated diabetes mellitus
No clinical signs of cerebral dysfunction
No severe psychiatric disease
No known HIV infection
No active chronic hepatitis B or C infection
No other concurrent diseases that exclude the administration of therapy as outlined by the study protocol
PRIOR CONCURRENT THERAPY:
See Disease Characteristics
More than 12 weeks since prior clinical trial participation
No prior participation in this study
No prior therapy, including murine antibody, for this cancer
No prior organ transplantation
No concurrent response-adapted radiotherapy ("iceberg radiotherapy")
No other concurrent anticancer chemotherapy or other study medication
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Michael G.M. Pfreundschuh, MD
Organizational Affiliation
Universitaetsklinikum des Saarlandes
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Norbert Schmitz, MD, PhD
Organizational Affiliation
Asklepios Klinik St. Georg
Official's Role
Study Chair
Facility Information:
Facility Name
University Hospital Brno
City
Brno
ZIP/Postal Code
CZ-662 63
Country
Czechia
Facility Name
Charles University Hospital
City
Prague 5
ZIP/Postal Code
CZ-150 06
Country
Czechia
Facility Name
Hopital Debrousse
City
Lyon
ZIP/Postal Code
69322
Country
France
Facility Name
Haematologisch Onkologische Praxis
City
Aachen
ZIP/Postal Code
52070
Country
Germany
Facility Name
Ostalb-Klinikum Aalen
City
Aalen
ZIP/Postal Code
D-73430
Country
Germany
Facility Name
Klinikum St. Marien
City
Amberg
ZIP/Postal Code
D-92224
Country
Germany
Facility Name
Gemeinschaftspraxis Fuer Innere Medizin, Haematologie Und Internistische Onkologie
City
Ansbach
ZIP/Postal Code
91522
Country
Germany
Facility Name
Specialist Practice for Oncology
City
Aschaffenburg
ZIP/Postal Code
63739
Country
Germany
Facility Name
II. Medizinische Klinik
City
Aschaffenburg
ZIP/Postal Code
RG 63739
Country
Germany
Facility Name
Haematologische Praxis
City
Augsburg
ZIP/Postal Code
86150
Country
Germany
Facility Name
Hamatologische/Onkologische Gemeinschaftspraxis - Augsburg
City
Augsburg
ZIP/Postal Code
86150
Country
Germany
Facility Name
Klinikum Augsburg
City
Augsburg
ZIP/Postal Code
DOH-86156
Country
Germany
Facility Name
Kreiskrankenhaus Aurich
City
Aurich
ZIP/Postal Code
26603
Country
Germany
Facility Name
Regional Hospital Bad Hersfeld
City
Bad Hersfeld
ZIP/Postal Code
36251
Country
Germany
Facility Name
HELIOS Klinikum Bad Saarow
City
Bad Saarow
ZIP/Postal Code
15526
Country
Germany
Facility Name
Internistische Praxis - Bad Salzuflen
City
Bad Salzuflen
ZIP/Postal Code
32105
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis und Tagesklinik Dres
City
Bad Soden
ZIP/Postal Code
65812
Country
Germany
Facility Name
Kreiskrankenhaus Bad Saeckingen
City
Bad Säckingen
ZIP/Postal Code
79704
Country
Germany
Facility Name
Ermstalklinik Bad Urach
City
Bad Urach
ZIP/Postal Code
D-72574
Country
Germany
Facility Name
Klinikum am Bamberg
City
Bamberg
ZIP/Postal Code
96049
Country
Germany
Facility Name
Krankenhaus Hohe Warte Mediziniche Klinik
City
Bayreuth
ZIP/Postal Code
95445
Country
Germany
Facility Name
Klinikum Bayreuth
City
Bayreuth
ZIP/Postal Code
D-95445
Country
Germany
Facility Name
Praxis Dr. med. Stefan Korsten
City
Bergisch Gladbach
ZIP/Postal Code
D-51429
Country
Germany
Facility Name
Onkologisches Versorgungszentrum Friedrichshain
City
Berlin
ZIP/Postal Code
10249
Country
Germany
Facility Name
DRK Kliniken Berlin - Koepenick
City
Berlin
ZIP/Postal Code
12559
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Berlin
City
Berlin
ZIP/Postal Code
13347
Country
Germany
Facility Name
Haematologisch-Onkologische Schwerpunktpraxis
City
Berlin
ZIP/Postal Code
13357
Country
Germany
Facility Name
Evang. Waldkrankenhaus Spandau
City
Berlin
ZIP/Postal Code
13589
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Berlin
City
Berlin
ZIP/Postal Code
14195
Country
Germany
Facility Name
Charite - Campus Charite Mitte
City
Berlin
ZIP/Postal Code
D-10117
Country
Germany
Facility Name
Onkolog - Haematolog Schwerpunktpraxis
City
Berlin
ZIP/Postal Code
D-10559
Country
Germany
Facility Name
Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin
City
Berlin
ZIP/Postal Code
D-12200
Country
Germany
Facility Name
Vivantes Klinikum Neukoelln
City
Berlin
ZIP/Postal Code
D-12351
Country
Germany
Facility Name
Robert Roessle Comprehensive Cancer Center - Charite Campus Buch
City
Berlin
ZIP/Postal Code
D-13125
Country
Germany
Facility Name
Hospital Complex Bernburg
City
Bernburg
ZIP/Postal Code
06406
Country
Germany
Facility Name
Franziskus Hospital
City
Bielefeld
ZIP/Postal Code
D-33615
Country
Germany
Facility Name
Krankenhaus Bietigheim
City
Bietigheim
ZIP/Postal Code
74319
Country
Germany
Facility Name
Saint Agnes Hospital
City
Bocholt
ZIP/Postal Code
DOH-463974290
Country
Germany
Facility Name
Augusta-Kranken-Anstalt gGmbH
City
Bochum
ZIP/Postal Code
D-44791
Country
Germany
Facility Name
St. Josef-Hospital - Bochum
City
Bochum
ZIP/Postal Code
D-44791
Country
Germany
Facility Name
Knappschaftskrankenhaus Bochum-Langendreer
City
Bochum
ZIP/Postal Code
D-44892
Country
Germany
Facility Name
Johanniter-Krankenhaus Bonn
City
Bonn
ZIP/Postal Code
53113
Country
Germany
Facility Name
Universitaetsklinikum Bonn
City
Bonn
ZIP/Postal Code
D-53105
Country
Germany
Facility Name
Medizinische Poliklinik
City
Bonn
ZIP/Postal Code
D-53111
Country
Germany
Facility Name
Praxis fuer Haematologie und Internistische Onkologie - Borken
City
Borken
ZIP/Postal Code
46325
Country
Germany
Facility Name
Knappschaftskrankenhaus Bottrop
City
Bottrop
ZIP/Postal Code
D-46242
Country
Germany
Facility Name
Hamatologische Sprechstunde
City
Brandenburg
ZIP/Postal Code
14770
Country
Germany
Facility Name
Staedtisches Klinikum Braunschweig
City
Braunschweig
ZIP/Postal Code
G-38114
Country
Germany
Facility Name
Praxis Dres. F.& G. Doering
City
Bremen
ZIP/Postal Code
28209
Country
Germany
Facility Name
Klinikum Bremen-Mitte
City
Bremen
ZIP/Postal Code
D-28205
Country
Germany
Facility Name
DIAKO Ev. Diakonie Krankenhaus gGmbH
City
Bremen
ZIP/Postal Code
D-28239
Country
Germany
Facility Name
St. Joseph Hospital
City
Bremerhaven
ZIP/Postal Code
D-27568
Country
Germany
Facility Name
Zentralkrankenhaus
City
Bremerhaven
ZIP/Postal Code
N 27574
Country
Germany
Facility Name
Praxis fuer Haematologie und Onkologie - Burgwedel
City
Burgwedel
ZIP/Postal Code
30938
Country
Germany
Facility Name
Medizinische Klinik am Lukas - Krankenhaus
City
Bünde
ZIP/Postal Code
32257
Country
Germany
Facility Name
General Hospital
City
Celle
ZIP/Postal Code
29223
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis Celle
City
Celle
ZIP/Postal Code
D-29221
Country
Germany
Facility Name
Hospital Kuchwald Chemnitz
City
Chemnitz
ZIP/Postal Code
D-09113
Country
Germany
Facility Name
Klinikum Coburg
City
Coburg
ZIP/Postal Code
96450
Country
Germany
Facility Name
Internistische Praxis - Coesfeld
City
Coesfeld
ZIP/Postal Code
48653
Country
Germany
Facility Name
Lung Clinic Cologne-Merheim
City
Cologne-Merheim
ZIP/Postal Code
D-51109
Country
Germany
Facility Name
Praxis Internistischer Onkologie und Haematologie - Koeln
City
Cologne
ZIP/Postal Code
50674
Country
Germany
Facility Name
Kliniken der Stadt Koeln gGmbH - Krankenhaus Holweide
City
Cologne
ZIP/Postal Code
51067
Country
Germany
Facility Name
Praxis fuer Onkologie - Kalk
City
Cologne
ZIP/Postal Code
51105
Country
Germany
Facility Name
Praxis Fuer Haematologie Internistische Onkologie
City
Cologne
ZIP/Postal Code
D-50677
Country
Germany
Facility Name
Medizinische Universitaetsklinik I at the University of Cologne
City
Cologne
ZIP/Postal Code
D-50924
Country
Germany
Facility Name
Carl - Thiem - Klinkum Cottbus
City
Cottbus
ZIP/Postal Code
D-03048
Country
Germany
Facility Name
Praxis Dr. Rheinhold Siegmund - Dr. Matthias Penke
City
Damme
ZIP/Postal Code
D-49401
Country
Germany
Facility Name
Klinikum Darmstadt
City
Darmstadt
ZIP/Postal Code
D-64283
Country
Germany
Facility Name
Staedtisches Klinikum Dessau
City
Dessau
ZIP/Postal Code
06822
Country
Germany
Facility Name
Internistische Praxis
City
Detmold
ZIP/Postal Code
32756
Country
Germany
Facility Name
Saint Johannes Hospital Dortmund
City
Dortmund
ZIP/Postal Code
44137
Country
Germany
Facility Name
Klinikum Dortmund
City
Dortmund
ZIP/Postal Code
D-44137
Country
Germany
Facility Name
Universitatsklinikum Carl Gustav Carus
City
Dresden
ZIP/Postal Code
D-01307
Country
Germany
Facility Name
Universitaetsklinikum Duesseldorf
City
Duesseldorf
ZIP/Postal Code
D-40225
Country
Germany
Facility Name
Johanniter-Krankenhaus Rheinhausen GmbH
City
Duisburg
ZIP/Postal Code
47228
Country
Germany
Facility Name
St. Johannes Hospital - Medical Klinik II
City
Duisburg
ZIP/Postal Code
D-47166
Country
Germany
Facility Name
Franz Hospital Dulmen
City
Dulmen
ZIP/Postal Code
48249
Country
Germany
Facility Name
Florence-Nightingale-Krankenhause, Deaconess Kaiserswerth
City
Dusseldorf
ZIP/Postal Code
40489
Country
Germany
Facility Name
Klinikum Barnim GmbH, Werner Forssmann Krankenhaus
City
Eberswalde
ZIP/Postal Code
16225
Country
Germany
Facility Name
Virngrund-Klinik Ellwangen
City
Ellwangen
ZIP/Postal Code
73479
Country
Germany
Facility Name
Hans - Susemihl - Krankenhaus
City
Emden
ZIP/Postal Code
26721
Country
Germany
Facility Name
Helios Klinikum Erfurt
City
Erfurt
ZIP/Postal Code
99089
Country
Germany
Facility Name
Medizinische Klinik III - Universitaetsklinikum Erlangen
City
Erlangen
ZIP/Postal Code
D-91054
Country
Germany
Facility Name
St. Antonius Hospital
City
Eschweiler
ZIP/Postal Code
DOH-52249
Country
Germany
Facility Name
Universitaetsklinikum Essen
City
Essen
ZIP/Postal Code
D-45122
Country
Germany
Facility Name
Evangelisches Krankenhaus Essen Werden
City
Essen
ZIP/Postal Code
D-45239
Country
Germany
Facility Name
Staedtische Kliniken Esslingen
City
Esslingen
ZIP/Postal Code
D-73730
Country
Germany
Facility Name
Schwerpunktpraxis fuer Haematologie und Onkologie - Flensburg
City
Flensburg
ZIP/Postal Code
24939
Country
Germany
Facility Name
Gemeinschaftspraxis fuer Internistische - Frankenthal
City
Frankenthal
ZIP/Postal Code
67227
Country
Germany
Facility Name
Klinikum Frankfurt (Oder) GmbH
City
Frankfurt (Oder)
ZIP/Postal Code
D-15236
Country
Germany
Facility Name
St. Marienkrankenhaus - Frankfurt am Main
City
Frankfurt am Main
ZIP/Postal Code
60318
Country
Germany
Facility Name
Onkologie Bethanien
City
Frankfurt
ZIP/Postal Code
D-60389
Country
Germany
Facility Name
Krankenhaus Nordwest
City
Frankfurt
ZIP/Postal Code
D-60488
Country
Germany
Facility Name
Klinikum der J.W. Goethe Universitaet
City
Frankfurt
ZIP/Postal Code
D-60590
Country
Germany
Facility Name
Praxis Internistischer Onkologie und Haematologie - Frechen
City
Frechen
ZIP/Postal Code
50226
Country
Germany
Facility Name
Gemeinschaftspraxis - Freiburg
City
Freiburg
ZIP/Postal Code
79098
Country
Germany
Facility Name
Evang. Deaconess Hospital Freiburg
City
Freiburg
ZIP/Postal Code
79110
Country
Germany
Facility Name
Praxis fur Interdisziplinaere Onkologie
City
Freiburg
ZIP/Postal Code
D-79106
Country
Germany
Facility Name
Universitaetsklinikum Freiburg
City
Freiburg
ZIP/Postal Code
D-79106
Country
Germany
Facility Name
Municipal Hospital Complex
City
Fulda
ZIP/Postal Code
36043
Country
Germany
Facility Name
Klinikum Garmisch - Partenkirchen GmbH
City
Garmisch-Partenkirchen
ZIP/Postal Code
D-82467
Country
Germany
Facility Name
Robert - Koch Hospital
City
Gehrden
ZIP/Postal Code
30989
Country
Germany
Facility Name
Saint Josef Hospital
City
Gelsenkirchen
ZIP/Postal Code
D-45899
Country
Germany
Facility Name
Internistische Praxisgemeinschaft
City
Germering
ZIP/Postal Code
82110
Country
Germany
Facility Name
Centre for Internal Medicine Giessen
City
Giessen
ZIP/Postal Code
35392
Country
Germany
Facility Name
Gemeinschaftspraxis Fuer Innere Medizin, Hematologie Und Onkologie
City
Giessen
ZIP/Postal Code
35392
Country
Germany
Facility Name
Wilhelm-Anton-Hospital gGmbH, Goch
City
Goch
ZIP/Postal Code
D-47574
Country
Germany
Facility Name
DR Herbert - Nieper Krankenhaus Goslar
City
Goslar
ZIP/Postal Code
38642
Country
Germany
Facility Name
Klinik Fuer Innere Medizin, Hematology/Oncology, Ernst Moritz Armdt Universitaet
City
Greifswald
ZIP/Postal Code
17487
Country
Germany
Facility Name
Kreiskrankenhaus Gummersbach GMBH
City
Gummersbach
ZIP/Postal Code
D-51643
Country
Germany
Facility Name
Internistisch-Haematologische Gemeinschaftspraxis - Gustrow
City
Gustrow
ZIP/Postal Code
18273
Country
Germany
Facility Name
Staedtisches Klinikum Görlitz GmbH
City
Görlitz
ZIP/Postal Code
02828
Country
Germany
Facility Name
Universitaetsklinikum Göttingen
City
Göttingen
ZIP/Postal Code
D-37075
Country
Germany
Facility Name
Staedtisches Klinikum Gütersloh
City
Gütersloh
ZIP/Postal Code
D-33332
Country
Germany
Facility Name
Allgemeines Krankenhaus Hagen
City
Hagen
ZIP/Postal Code
D-58095
Country
Germany
Facility Name
St. Marien Hospital - Katholisches Krankenhaus Hagen gGmbH
City
Hagen
ZIP/Postal Code
D-58095
Country
Germany
Facility Name
St. Salvator Krankenhaus
City
Halberstadt
ZIP/Postal Code
D 38820
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Halle
City
Halle
ZIP/Postal Code
06110
Country
Germany
Facility Name
Universitaetsklinikum Halle
City
Halle
ZIP/Postal Code
D-06097
Country
Germany
Facility Name
Krankenhaus St. Elisabeth und St. Barbara
City
Halle
ZIP/Postal Code
D-06110
Country
Germany
Facility Name
Krankenhaus Martha-Maria Halle-Doelau gGmbH
City
Halle
ZIP/Postal Code
D-06120
Country
Germany
Facility Name
St. Sixtus Hospital
City
Haltern
ZIP/Postal Code
D-45721
Country
Germany
Facility Name
Praxis fuer Innere Medizin - Bergedorf
City
Hamburg
ZIP/Postal Code
21029
Country
Germany
Facility Name
Marienkrankenhaus
City
Hamburg
ZIP/Postal Code
22087
Country
Germany
Facility Name
Allgemeines Krankenhaus Altona
City
Hamburg
ZIP/Postal Code
22763
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis Dr. med. Verpoort, PD Dr. med. Zeller and Dr. med. Wierecky
City
Hamburg
ZIP/Postal Code
D-20095
Country
Germany
Facility Name
Asklepios Klinik St. Georg
City
Hamburg
ZIP/Postal Code
D-20099
Country
Germany
Facility Name
University Medical Center Hamburg - Eppendorf
City
Hamburg
ZIP/Postal Code
D-20246
Country
Germany
Facility Name
Asklepios Klinik Nord Heidberg
City
Hamburg
ZIP/Postal Code
D-22417
Country
Germany
Facility Name
Haematologisch-Onkologische Praxis Altona
City
Hamburg
ZIP/Postal Code
D-22767
Country
Germany
Facility Name
St. Marien Hospital
City
Hamm
ZIP/Postal Code
59065
Country
Germany
Facility Name
Evangelische Krankenhaus Hamm
City
Hamm
ZIP/Postal Code
D-59063
Country
Germany
Facility Name
Klinikum Stadt Hanau
City
Hanau
ZIP/Postal Code
63450
Country
Germany
Facility Name
Schwerpunktpraxis Haematologie/Onkologie - Hannover
City
Hannover
ZIP/Postal Code
30169
Country
Germany
Facility Name
Krankenhaus Siloah - Medizinische Klinik II
City
Hannover
ZIP/Postal Code
D-30449
Country
Germany
Facility Name
Henriettenstiftung Frauenklinik
City
Hannover
ZIP/Postal Code
D-30559
Country
Germany
Facility Name
Medizinische Hochschule Hannover
City
Hannover
ZIP/Postal Code
D-30625
Country
Germany
Facility Name
Oncology Specialists Clinic
City
Harrislee
ZIP/Postal Code
D-24955
Country
Germany
Facility Name
Ruprecht - Karls - Universitaet Heidelberg
City
Heidelberg
ZIP/Postal Code
D-69117
Country
Germany
Facility Name
Thoraxklinik Heidelberg
City
Heidelberg
ZIP/Postal Code
D-69126
Country
Germany
Facility Name
Regional Hospital Heidenheim
City
Heidenheim
ZIP/Postal Code
89522
Country
Germany
Facility Name
Regional Hospital Am Plattenwald Bad Friedrichshall
City
Heilbronn
ZIP/Postal Code
74177
Country
Germany
Facility Name
Klinikum Herford
City
Herford
ZIP/Postal Code
D-32049
Country
Germany
Facility Name
Marienhospital at Ruhr University Bochum
City
Herne
ZIP/Postal Code
D-44625
Country
Germany
Facility Name
Privatklinik Dr. R. Schindlbeck GmbH & Co. KG
City
Herrsching Am Ammersee
ZIP/Postal Code
D-82211
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis
City
Hildesheim
ZIP/Postal Code
D-31134
Country
Germany
Facility Name
St. Bernward Krankenhaus
City
Hildesheim
ZIP/Postal Code
D-31134
Country
Germany
Facility Name
Staedtisches Krankenhaus Hildesheim
City
Hildesheim
ZIP/Postal Code
D-31134
Country
Germany
Facility Name
Evang. Hospital
City
Holzminden
ZIP/Postal Code
37603
Country
Germany
Facility Name
Haematologie und Internistische Onkologie Praxis
City
Homberg
ZIP/Postal Code
D-34576
Country
Germany
Facility Name
Universitaetsklinikum des Saarlandes
City
Homburg
ZIP/Postal Code
D-66424
Country
Germany
Facility Name
Hospital Complex Hoyerswerda
City
Hoyerswerda
ZIP/Postal Code
02977
Country
Germany
Facility Name
Clinic for Bone Marrow Transplantation and Hematology and Oncology
City
Idar-Oberstein
ZIP/Postal Code
D-55743
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Jena
City
Jena
ZIP/Postal Code
07743
Country
Germany
Facility Name
Klinikum der Friedrich-Schiller Universitaet Jena
City
Jena
ZIP/Postal Code
07747
Country
Germany
Facility Name
Onkologische Gemeinschaftspraxis - Kaiserslautern
City
Kaiserslautern
ZIP/Postal Code
67655
Country
Germany
Facility Name
Westpfalz-Klinikum GmbH
City
Kaiserslautern
ZIP/Postal Code
D-67653
Country
Germany
Facility Name
Staedtisches Klinikum Karlsruhe gGmbH
City
Karlsruhe
ZIP/Postal Code
76133
Country
Germany
Facility Name
St. Vincentius - Kliniken
City
Karlsruhe
ZIP/Postal Code
D-76137
Country
Germany
Facility Name
Red Cross Hospital Kassel
City
Kassel
ZIP/Postal Code
34121
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Kassel
City
Kassel
ZIP/Postal Code
D-34117
Country
Germany
Facility Name
Klinikum Kempten Oberallgaeu
City
Kempten
ZIP/Postal Code
D-87439
Country
Germany
Facility Name
Staedtisches Krankenhaus Kiel
City
Kiel
ZIP/Postal Code
23116
Country
Germany
Facility Name
Praxis fuer Haematologie und Onkologie
City
Koblenz
ZIP/Postal Code
D-56068
Country
Germany
Facility Name
Stiftungsklinikum Mittelrhein - Gesundheitszentrum Evangelisches Stift Sankt Martin Koblenz gGmbH
City
Koblenz
ZIP/Postal Code
D-56068
Country
Germany
Facility Name
Leonardis Clinic
City
Kornwestheim
ZIP/Postal Code
D-70806
Country
Germany
Facility Name
Haematologische / Onkologische Schwerpunktpraxis
City
Krefeld
ZIP/Postal Code
47798
Country
Germany
Facility Name
Klinikum Krefeld GmbH
City
Krefeld
ZIP/Postal Code
D-47805
Country
Germany
Facility Name
Internistische Onkologische Praxis - Kronach
City
Kronach
ZIP/Postal Code
96317
Country
Germany
Facility Name
Frankenwald Klinik
City
Kronach
ZIP/Postal Code
D-96317
Country
Germany
Facility Name
Internistische Praxis - Landshut
City
Landshut
ZIP/Postal Code
84028
Country
Germany
Facility Name
Klinikum Landshut
City
Landshut
ZIP/Postal Code
84034
Country
Germany
Facility Name
Caritas - Krakenhaus Lebach
City
Lebach
ZIP/Postal Code
66822
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis - Leer
City
Leer
ZIP/Postal Code
D-26789
Country
Germany
Facility Name
Praxis fuer Onkologie am Diakonissenhaus
City
Leipzig
ZIP/Postal Code
04179
Country
Germany
Facility Name
Forschungsgesellschaft mbH
City
Leipzig
ZIP/Postal Code
04289
Country
Germany
Facility Name
Gemeinschaftspraxis fuer Dres. Aldaoud und Schwarzer
City
Leipzig
ZIP/Postal Code
04289
Country
Germany
Facility Name
University Leipzig Clinic of Internal Medicine
City
Leipzig
ZIP/Postal Code
D-04103
Country
Germany
Facility Name
Klinikum "St. Georg" Leipzig
City
Leipzig
ZIP/Postal Code
D-04129
Country
Germany
Facility Name
Klinikum Lippe - Lemgo
City
Lemgo
ZIP/Postal Code
D-32657
Country
Germany
Facility Name
St. Vincenz Hospital Limburg
City
Limburg
ZIP/Postal Code
D-65549
Country
Germany
Facility Name
St. Bonifatius Hospital Lingen
City
Lingen
ZIP/Postal Code
D-49808
Country
Germany
Facility Name
Dreifaltigkeits Hospital
City
Lippstadt
ZIP/Postal Code
D-59555
Country
Germany
Facility Name
Kreiskrankenhaus Loerrach
City
Loerrach
ZIP/Postal Code
79539
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis
City
Loerrach
ZIP/Postal Code
D-79539
Country
Germany
Facility Name
Klinikum Ludwigsburg
City
Ludwigsburg
ZIP/Postal Code
D-71640
Country
Germany
Facility Name
Klinikum der Stadt Ludwigshafen am Rhein
City
Ludwigshafen am Rhein
ZIP/Postal Code
D-67063
Country
Germany
Facility Name
St. Marien Hospital Ludwighafen
City
Ludwigshafen
ZIP/Postal Code
D-67067
Country
Germany
Facility Name
Schwerpunktpraxis fuer Haematologie und Onkologie - Luebeck
City
Luebeck
ZIP/Postal Code
23562
Country
Germany
Facility Name
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
City
Luebeck
ZIP/Postal Code
D-23538
Country
Germany
Facility Name
Sana Kliniken Luebeck
City
Luebeck
ZIP/Postal Code
D-23560
Country
Germany
Facility Name
Kreiskrankenhaus Luedenscheid
City
Luedenscheid
ZIP/Postal Code
58515
Country
Germany
Facility Name
Universitatsklinikum der MA
City
Magdeburg
ZIP/Postal Code
39120
Country
Germany
Facility Name
Staedtisches Klinikum Magdeburg - Altstadt
City
Magdeburg
ZIP/Postal Code
D-39002
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Magdeburg
City
Magdeburg
ZIP/Postal Code
D-39104
Country
Germany
Facility Name
St. Vincenz und Elisabeth Hospital
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Johannes Gutenberg University
City
Mainz
ZIP/Postal Code
D-55101
Country
Germany
Facility Name
Gemeinschaftspraxis
City
Mannheim
ZIP/Postal Code
D-68161
Country
Germany
Facility Name
III Medizinische Klinik Mannheim
City
Mannheim
ZIP/Postal Code
D-68305
Country
Germany
Facility Name
Schwerpunktpraxis Internist Onkologie - Marburg
City
Marburg
ZIP/Postal Code
35057
Country
Germany
Facility Name
Universitaetsklinikum Giessen und Marburg GmbH - Marburg
City
Marburg
ZIP/Postal Code
D-35043
Country
Germany
Facility Name
Regional Hospital Mayen
City
Mayen
ZIP/Postal Code
D-56727
Country
Germany
Facility Name
Gemeinschaftspraxis Dres. med. Ellbrueck/Goeller/Kraenzle/Niedermeier/Jocham
City
Memmingen
ZIP/Postal Code
87700
Country
Germany
Facility Name
Krankenhaus Ludmillenstift
City
Meppen
ZIP/Postal Code
49716
Country
Germany
Facility Name
Gemeinschaftspraxis - Minden
City
Minden
ZIP/Postal Code
32427
Country
Germany
Facility Name
Klinikum Minden
City
Minden
ZIP/Postal Code
D-32423
Country
Germany
Facility Name
Krankenhaus Maria Hilf GmbH
City
Moenchengladbach
ZIP/Postal Code
D-41063
Country
Germany
Facility Name
Haematologische Praxis - Moenchengladbach
City
Moenchengladbach
ZIP/Postal Code
D-41239
Country
Germany
Facility Name
Ev. Hospital Bethesda
City
Monchengladbach
ZIP/Postal Code
D-41061
Country
Germany
Facility Name
Evangelisches Krankenhaus - Muelheim
City
Muelheim an der Ruhr
ZIP/Postal Code
45466
Country
Germany
Facility Name
St. Marien Hospital - Muelheim an der Ruhr
City
Muelheim An Der Ruhr
ZIP/Postal Code
D-45468
Country
Germany
Facility Name
Gemeinschaftspraxis - Muenster
City
Muenster
ZIP/Postal Code
48145
Country
Germany
Facility Name
Haematologisch - Onkologische Gemeinschaftspraxis - Muenster
City
Muenster
ZIP/Postal Code
D-48149
Country
Germany
Facility Name
Klinik und Poliklinik fuer Kinder und Jugendmedizin - Universitaetsklinikum Muenster
City
Muenster
ZIP/Postal Code
D-48149
Country
Germany
Facility Name
Universitaets - Kinderpoliklinik
City
Munich
ZIP/Postal Code
80336
Country
Germany
Facility Name
Krankenhaus Muenchen Schwabing
City
Munich
ZIP/Postal Code
80804
Country
Germany
Facility Name
Munich Oncologic Practice at Elisenhof
City
Munich
ZIP/Postal Code
D-80335
Country
Germany
Facility Name
Klinikum der Universitaet Muenchen - Grosshadern Campus
City
Munich
ZIP/Postal Code
D-81377
Country
Germany
Facility Name
Staedtisches Krankenhaus Muenchen - Harlaching
City
Munich
ZIP/Postal Code
D-81545
Country
Germany
Facility Name
Klinikum Rechts Der Isar - Technische Universitaet Muenchen
City
Munich
ZIP/Postal Code
D-81675
Country
Germany
Facility Name
Municipal Hospital Munich
City
Munich
ZIP/Postal Code
D-81737
Country
Germany
Facility Name
Klinikum Schwaebisch Gmuend Stauferklinik
City
Mutlangen
ZIP/Postal Code
D-73557
Country
Germany
Facility Name
Kreiskrankenhaus Muenchberg
City
Münchberg
ZIP/Postal Code
D-95213
Country
Germany
Facility Name
Staedtisches Krankenhaus Nettetal GmbH
City
Nettetal
ZIP/Postal Code
41334
Country
Germany
Facility Name
Klinikum Neubrandenburg
City
Neubrandenburg
ZIP/Postal Code
17036
Country
Germany
Facility Name
Onkologische Schwerwpunktpraxis Dr. Ladda
City
Neumarkt
ZIP/Postal Code
D-92318
Country
Germany
Facility Name
Regional Hospital Neumarkt
City
Neumarkt
ZIP/Postal Code
D-92318
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis Dr. Schmidt
City
Neunkirchen
ZIP/Postal Code
D-66538
Country
Germany
Facility Name
Staedtisches Klinikum Neunkirchen gGmbH
City
Neunkirchen
ZIP/Postal Code
D-66538
Country
Germany
Facility Name
Internistische Praxis - Neuss
City
Neuss
ZIP/Postal Code
41460
Country
Germany
Facility Name
Lukaskrankenhaus Neuss
City
Neuss
ZIP/Postal Code
D-41464
Country
Germany
Facility Name
DRK Krankenhaus Neuwied
City
Neuwied
ZIP/Postal Code
56564
Country
Germany
Facility Name
Praxis fuer Haematologie und Interne Onkologie
City
Norderstedt
ZIP/Postal Code
22844
Country
Germany
Facility Name
Gemeinschaftspraxis fuer Onkologie - Nordhorn
City
Nordhorn
ZIP/Postal Code
48527
Country
Germany
Facility Name
Gemeinschaftspraxis fuer Haematologie - Northeim
City
Northeim
ZIP/Postal Code
37154
Country
Germany
Facility Name
Praxisklinik fuer Innere Medizin - Nuernberg
City
Nuremberg
ZIP/Postal Code
90449
Country
Germany
Facility Name
Klinikum Nuernberg - Klinikum Nord
City
Nuremberg
ZIP/Postal Code
D-90419
Country
Germany
Facility Name
Schlossbergkliniken Oberstaufen
City
Oberstaufen
ZIP/Postal Code
D-87534
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Offenbach
City
Offenbach
ZIP/Postal Code
D-63065
Country
Germany
Facility Name
Klinikum Offenburg
City
Offenburg
ZIP/Postal Code
D-77654
Country
Germany
Facility Name
Pius Hospital - Oldenburg
City
Oldenburg
ZIP/Postal Code
26121
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Oldenburg
City
Oldenburg
ZIP/Postal Code
D-26121
Country
Germany
Facility Name
Ev. Hospital Oldenburg
City
Oldenburg
ZIP/Postal Code
D-26122
Country
Germany
Facility Name
Klinikum Oldenburg
City
Oldenburg
ZIP/Postal Code
D-26133
Country
Germany
Facility Name
St. Martinus Hospital - Olpe
City
Olpe
ZIP/Postal Code
57462
Country
Germany
Facility Name
Marien Hospital
City
Osnabrück
ZIP/Postal Code
D-49074
Country
Germany
Facility Name
Klinikum Osnabrück GmbH
City
Osnabrück
ZIP/Postal Code
D-49076
Country
Germany
Facility Name
Paracelsus - Klinik Osnabrück
City
Osnabrück
ZIP/Postal Code
D-49076
Country
Germany
Facility Name
Bruederkrankenhaus St. Josef Paderborn
City
Paderborn
ZIP/Postal Code
D-33098
Country
Germany
Facility Name
Asklepios Klinik - Parchim
City
Parchim
ZIP/Postal Code
19370
Country
Germany
Facility Name
Staedtisches Krankenhaus
City
Pforzheim
ZIP/Postal Code
75175
Country
Germany
Facility Name
Krankenhaus Siloah - Pforzheim
City
Pforzheim
ZIP/Postal Code
75179
Country
Germany
Facility Name
Praxis fuer Innere Medizin am Krankenhaus Siloah - Pforzheim
City
Pforzheim
ZIP/Postal Code
75179
Country
Germany
Facility Name
Gemeinschaftspraxis - Pinneberg
City
Pinneberg
ZIP/Postal Code
25421
Country
Germany
Facility Name
Klinikum Ernst Von Bergmann
City
Potsdam
ZIP/Postal Code
D-14467
Country
Germany
Facility Name
Kreiskrankenhaus Radebeul
City
Radebeul
ZIP/Postal Code
D-01445
Country
Germany
Facility Name
Gemeinschaftspraxis - Ravensburg
City
Ravensburg
ZIP/Postal Code
88212
Country
Germany
Facility Name
Krankenhaus St. Elisabeth - Ravensburg
City
Ravensburg
ZIP/Postal Code
D-88212
Country
Germany
Facility Name
Elisabeth Krankenhaus
City
Recklinghausen
ZIP/Postal Code
45661
Country
Germany
Facility Name
Prosper-Hospital Recklinghausen
City
Recklinghausen
ZIP/Postal Code
DOH-45659
Country
Germany
Facility Name
Hematologische Onkologische Praxis
City
Regensburg
ZIP/Postal Code
93047
Country
Germany
Facility Name
Klinikum der Universitaet Regensburg
City
Regensburg
ZIP/Postal Code
D-93042
Country
Germany
Facility Name
Krankenhaus Barmherzige Brueder Regensburg
City
Regensburg
ZIP/Postal Code
D-93049
Country
Germany
Facility Name
Internistische Praxis Dres. Hempel und Hochdorfer
City
Rehling
ZIP/Postal Code
86508
Country
Germany
Facility Name
Klinikum Remscheid GmbH
City
Remscheid
ZIP/Postal Code
D-42859
Country
Germany
Facility Name
Jakobi Krankenhaus
City
Rheine
ZIP/Postal Code
48431
Country
Germany
Facility Name
Haematologische/Onkologische Schwerpunktpraxis - Rostock
City
Rostock
ZIP/Postal Code
18057
Country
Germany
Facility Name
Klinik und Poliklinik fuer Innere Medizin - Universitaet Rostock
City
Rostock
ZIP/Postal Code
D-18055
Country
Germany
Facility Name
Klinikum Suedstadt Rostock
City
Rostock
ZIP/Postal Code
D-18059
Country
Germany
Facility Name
Diakonie - Krankenhaus
City
Rotenburg
ZIP/Postal Code
DOH-27356
Country
Germany
Facility Name
Internistische Schwerpunktpraxis
City
Russelsheim
ZIP/Postal Code
65428
Country
Germany
Facility Name
Caritasklinik St. Theresia
City
Saarbrucken
ZIP/Postal Code
D-66113
Country
Germany
Facility Name
Gemeinschaftspraxis - Saarbruecken
City
Saarbruecken
ZIP/Postal Code
66113
Country
Germany
Facility Name
St. Elizabeth-Klinik Saarlouis
City
Saarlouis
ZIP/Postal Code
D-66713
Country
Germany
Facility Name
Martin - Luther Hospital
City
Schleswig
ZIP/Postal Code
D-24837
Country
Germany
Facility Name
Praxis fur Innere Medizin - Schmiedeberg
City
Schmiedeberg
ZIP/Postal Code
01762
Country
Germany
Facility Name
Deaconess Hospital
City
Schwabisch Hall
ZIP/Postal Code
D-74523
Country
Germany
Facility Name
Gemeinschaftspraxis fuer Haematologie und Internist - Schweinfurt
City
Schweinfurt
ZIP/Postal Code
97421
Country
Germany
Facility Name
Leopoldina - Krankenhaus
City
Schweinfurt
ZIP/Postal Code
D-97422
Country
Germany
Facility Name
HELIOS Klinikum - Schwelm
City
Schwelm
ZIP/Postal Code
58332
Country
Germany
Facility Name
Klinikum Schwerin
City
Schwerin
ZIP/Postal Code
D-19049
Country
Germany
Facility Name
St. Marien - Krankenhaus Siegen GMBH
City
Siegen
ZIP/Postal Code
D-57072
Country
Germany
Facility Name
Evang. Jung-Stilling Hospital
City
Siegen
ZIP/Postal Code
D-57074
Country
Germany
Facility Name
St. Lukas - Clinic Solingen
City
Solingen
ZIP/Postal Code
D-42697
Country
Germany
Facility Name
Krankenhaus Maria-Hilf - Stadtlohn
City
Stadtlohn
ZIP/Postal Code
48703
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis - Straubing
City
Straubing
ZIP/Postal Code
94315
Country
Germany
Facility Name
Hospital Bad Cannstatt
City
Stuttgart
ZIP/Postal Code
70374
Country
Germany
Facility Name
Haematologische Praxis
City
Stuttgart
ZIP/Postal Code
D-70173
Country
Germany
Facility Name
Klinik fuer Onkologie - Katharinenhospital Stuttgart
City
Stuttgart
ZIP/Postal Code
D-70174
Country
Germany
Facility Name
Diakonie Klinikum Stuttgart
City
Stuttgart
ZIP/Postal Code
D-70176
Country
Germany
Facility Name
Gastroenterologische und Haematologisch-Onkologische Praxis E. M. Dr. Hoering von Ehr Respondek
City
Stuttgart
ZIP/Postal Code
D-70176
Country
Germany
Facility Name
Klinikum Stuttgart - Buergerhospital
City
Stuttgart
ZIP/Postal Code
D-70191
Country
Germany
Facility Name
Robert-Bosch-Krankenhaus
City
Stuttgart
ZIP/Postal Code
D-70376
Country
Germany
Facility Name
St. Elisabeth Hospital Thuine
City
Thuine
ZIP/Postal Code
D-49832
Country
Germany
Facility Name
Regional Hospital Traunstein
City
Traunstein
ZIP/Postal Code
D-83278
Country
Germany
Facility Name
Onkologische Gemeinschaftspraxis - Trier
City
Trier
ZIP/Postal Code
54290
Country
Germany
Facility Name
Krankenanstalt Mutterhaus der Borromaerinnen
City
Trier
ZIP/Postal Code
D-54219
Country
Germany
Facility Name
Krankenhaus Der Barmherzigen Brueder
City
Trier
ZIP/Postal Code
D-54292
Country
Germany
Facility Name
Praxis Fuer Internistische Haematologie / Onkologie
City
Troisdorf
ZIP/Postal Code
53840
Country
Germany
Facility Name
Universitaetsklinikum Tuebingen
City
Tuebingen
ZIP/Postal Code
D-72076
Country
Germany
Facility Name
Hospital Tutzing
City
Tutzing
ZIP/Postal Code
D-82327
Country
Germany
Facility Name
Praxis fuer Haematologie und Onkologie
City
Twistringen
ZIP/Postal Code
D-27239
Country
Germany
Facility Name
Comprehensive Cancer Center Ulm at Universitaetsklinikum Ulm
City
Ulm
ZIP/Postal Code
D-89081
Country
Germany
Facility Name
Ev. Hospital Unna
City
Unna
ZIP/Postal Code
D-59403
Country
Germany
Facility Name
St. Marienhospital - Vechta
City
Vechta
ZIP/Postal Code
D-49377
Country
Germany
Facility Name
Municipal Hospital Complex
City
Villingen-Schwenningen
ZIP/Postal Code
D-78050
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis - Villingen
City
Villingen
ZIP/Postal Code
78050
Country
Germany
Facility Name
Regional Hospital Waldbrol
City
Waldbrol
ZIP/Postal Code
D-51545
Country
Germany
Facility Name
Haematologische Praxis
City
Weiden
ZIP/Postal Code
D-92637
Country
Germany
Facility Name
Gemeinschaftspraxis feur Haemotologie und Onkologie - Weilheim
City
Weilheim
ZIP/Postal Code
82362
Country
Germany
Facility Name
Sophien - und Hufeland - Klinikum Weimar gGmbH
City
Weimar
ZIP/Postal Code
99425
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis
City
Wendlingen
ZIP/Postal Code
73240
Country
Germany
Facility Name
Harz-Klinikum Wernigerode-Blankenburg GmbH
City
Wernigerode
ZIP/Postal Code
38855
Country
Germany
Facility Name
Asklepios Nordseeklinik Westerland GmbH
City
Westerland
ZIP/Postal Code
25980
Country
Germany
Facility Name
Ammerland-Klinik GmbH
City
Westerstede
ZIP/Postal Code
26655
Country
Germany
Facility Name
Hospital Wetzler
City
Wetzlar
ZIP/Postal Code
D-35578
Country
Germany
Facility Name
Deutsche Klinik fuer Diagnostik
City
Wiesbaden
ZIP/Postal Code
D-65191
Country
Germany
Facility Name
Dr. Horst-Schmidt-Kliniken
City
Wiesbaden
ZIP/Postal Code
D-65199
Country
Germany
Facility Name
Evangelisches Krankenhaus - Lutherstadt Wittenberg
City
Wittenberg
ZIP/Postal Code
06886
Country
Germany
Facility Name
Ev. Hospital Witten-Herdecke
City
Witten
ZIP/Postal Code
D-58455
Country
Germany
Facility Name
Klinikum der Stadt Wolfsburg
City
Wolfsburg
ZIP/Postal Code
D-38440
Country
Germany
Facility Name
Burkhard and Reimann Gemeinschaftspraxis
City
Worms
ZIP/Postal Code
67547
Country
Germany
Facility Name
Medizinische Poliklinik, Universitaet Wuerzburg
City
Wuerzburg
ZIP/Postal Code
D-97070
Country
Germany
Facility Name
Kliniken St. Antonius
City
Wuppertal 2
ZIP/Postal Code
D-42283
Country
Germany
Facility Name
Helios Kliniken Wuppertal University Hospital
City
Wuppertal
ZIP/Postal Code
D-42283
Country
Germany
Facility Name
Heinrich-Braun-Krankenhaus Zwickau
City
Zwickau
ZIP/Postal Code
08009
Country
Germany
Facility Name
Azienda Ospedaliera di Padova
City
Padova
ZIP/Postal Code
35128
Country
Italy
Facility Name
Erasmus MC - Sophia Children's Hospital
City
Rotterdam
ZIP/Postal Code
3015 GJ
Country
Netherlands
Facility Name
Akademia Medyczna im. Piastow Slaskich
City
Wroclaw
ZIP/Postal Code
50-367
Country
Poland
Facility Name
Goeteborg University
City
Goeteborg
ZIP/Postal Code
S-141685
Country
Sweden
Facility Name
Kantonsspital Aarau
City
Aarau
ZIP/Postal Code
CH-5001
Country
Switzerland
Facility Name
Universitaets-Kinderspital beider Basel
City
Basel
ZIP/Postal Code
CH-4005
Country
Switzerland
Facility Name
Ospedale "la Carita", Locarno
City
Locarno
ZIP/Postal Code
6600
Country
Switzerland
Facility Name
Kinderspital Luzern
City
Lucerne 16
ZIP/Postal Code
CH-6000
Country
Switzerland
Facility Name
Ostschweizer Kinderspital
City
St. Gallen
ZIP/Postal Code
CH-9006
Country
Switzerland
Facility Name
University Children's Hospital
City
Zurich
ZIP/Postal Code
CH-8032
Country
Switzerland
Facility Name
Royal Manchester Children's Hospital
City
Manchester
State/Province
England
ZIP/Postal Code
M27 4HA
Country
United Kingdom
12. IPD Sharing Statement
Learn more about this trial
Rituximab and Combination Chemotherapy in Treating Older Patients With Previously Untreated B-Cell Lymphoma
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