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Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer, Metastatic Kidney Cancer, or Aplastic Anemia

Primary Purpose

Chronic Myeloproliferative Disorders, Kidney Cancer, Leukemia

Status
Unknown status
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
anti-thymocyte globulin
filgrastim
graft-versus-tumor induction therapy
therapeutic allogeneic lymphocytes
busulfan
cyclophosphamide
fludarabine phosphate
methotrexate
mycophenolate mofetil
tacrolimus
allogeneic bone marrow transplantation
nonmyeloablative allogeneic hematopoietic stem cell transplantation
peripheral blood stem cell transplantation
Sponsored by
University of California, San Francisco
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an interventional treatment trial for Chronic Myeloproliferative Disorders focused on measuring adult acute myeloid leukemia with 11q23 (MLL) abnormalities, adult acute myeloid leukemia with inv(16)(p13;q22), adult acute myeloid leukemia with t(15;17)(q22;q12), adult acute myeloid leukemia with t(16;16)(p13;q22), accelerated phase chronic myelogenous leukemia, adult acute lymphoblastic leukemia in remission, adult acute myeloid leukemia in remission, atypical chronic myeloid leukemia, BCR-ABL1 negative, blastic phase chronic myelogenous leukemia, childhood acute lymphoblastic leukemia in remission, childhood acute myeloid leukemia in remission, childhood chronic myelogenous leukemia, chronic eosinophilic leukemia, primary myelofibrosis, chronic myelomonocytic leukemia, chronic neutrophilic leukemia, chronic phase chronic myelogenous leukemia, de novo myelodysplastic syndromes, essential thrombocythemia, juvenile myelomonocytic leukemia, myelodysplastic/myeloproliferative neoplasm, unclassifiable, polycythemia vera, previously treated myelodysplastic syndromes, recurrent adult acute myeloid leukemia, prolymphocytic leukemia, recurrent adult Hodgkin lymphoma, recurrent adult diffuse large cell lymphoma, recurrent adult immunoblastic large cell lymphoma, recurrent adult lymphoblastic lymphoma, recurrent/refractory childhood Hodgkin lymphoma, recurrent childhood acute lymphoblastic leukemia, recurrent childhood acute myeloid leukemia, recurrent childhood large cell lymphoma, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma, recurrent mantle cell lymphoma, refractory chronic lymphocytic leukemia, refractory multiple myeloma, relapsing chronic myelogenous leukemia, secondary acute myeloid leukemia, secondary myelodysplastic syndromes, stage II multiple myeloma, stage III chronic lymphocytic leukemia, stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage III multiple myeloma, stage IV chronic lymphocytic leukemia, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma, recurrent renal cell cancer, stage IV renal cell cancer, noncontiguous stage II grade 1 follicular lymphoma, noncontiguous stage II grade 2 follicular lymphoma, noncontiguous stage II grade 3 follicular lymphoma, recurrent adult acute lymphoblastic leukemia, childhood myelodysplastic syndromes

Eligibility Criteria

undefined - 74 Years (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

DISEASE CHARACTERISTICS: Diagnosis of 1 of the following: Aplastic anemia not responsive to immunosuppressive therapy Metastatic renal cell carcinoma Hematologic malignancy, including any of the following: Acute myeloid leukemia (AML)* not curable with chemotherapy and meeting any of the following criteria: AML with high-risk cytogenetic abnormalities (e.g., -7, -7q, -5, -5q, complex, Philadelphia chromosome-positive [Ph+]) AML evolved from prior myelodysplasia AML secondary to prior chemotherapy Failed to achieve remission In second or subsequent remission NOTE: *Marrow blasts < 10%- can be achieved by chemotherapy Myelodysplasia* with any of the following high-risk features: Adverse cytogenetics (-7, 7q, -5, -5q, complex) Excess blasts Prior conversion to AML Severe cytopenias with absolute neutrophil count < 500/mm^3 or platelet count < 20,000/mm^3 NOTE: *Marrow blasts < 10%- can be achieved by chemotherapy Acute lymphoblastic leukemia (ALL)* not curable with chemotherapy and meeting any of the following criteria: High-risk cytogenetics (Ph+, 11q23 abnormalities, monosomy 7) More than 1 induction course required to achieve remission Failed to enter remission In second or subsequent remission NOTE: *Marrow blasts < 10 % Chronic lymphocytic leukemia (CLL) with high-risk features, including any of the following: Refractory to initial or subsequent therapy Progression after initial response to therapy Prolymphocytic morphology Follicular lymphoma with any of the following high-risk features: Refractory to initial or subsequent therapy Progression after response to initial therapy Has ≥ 3 International Prognostic Index (IPI) risk factors Multiple myeloma Stage II-III disease confirmed at diagnosis or after initial progression Other lymphoma that has failed to respond to primary therapy, progressed, or recurred after prior therapy, including any of the following: Diffuse large cell lymphoma Mantle cell lymphoma Hodgkin's lymphoma Myeloproliferative disease with evidence of disease acceleration, including any of the following: Myelofibrosis Polycythemia vera Essential thrombocythemia Chronic myeloid leukemia (CML) that failed to be controlled by imatinib mesylate Disease must be stable or responding to therapy No rapid progression of malignant disease Expected time to disease progression > 12 weeks Not eligible for autologous stem cell transplantation Matched unrelated donor available 9/10 HLA matched, including HLA-A, -B, -C, -DR, and -DQ PATIENT CHARACTERISTICS: Creatinine < 2.0 mg/dL Creatinine clearance > 40 mL/min Bilirubin < 3 mg/dL Elevated total bilirubin due to Gilbert's disease allowed if direct bilirubin is normal AST < 4 times upper limit of normal Hepatitis C or B allowed provided bilirubin and AST are normal Cardiac ejection fraction > 30% DLCO > 40% of predicted Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No uncontrolled active infection requiring ongoing antibiotic treatment No poor performance status No poor organ function PRIOR CONCURRENT THERAPY: See Disease Characteristics Prior stem cell or bone marrow transplantation allowed

Sites / Locations

  • UCSF Comprehensive Cancer Center
  • Wake Forest University Comprehensive Cancer Center

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
February 23, 2006
Last Updated
January 3, 2014
Sponsor
University of California, San Francisco
Collaborators
National Cancer Institute (NCI)
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1. Study Identification

Unique Protocol Identification Number
NCT00295997
Brief Title
Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer, Metastatic Kidney Cancer, or Aplastic Anemia
Official Title
Non-myeloablative Allogeneic Stem Cell Transplantation With Match Unrelated Donors for Treatment of Hematologic Malignancies and Renal Cell Carcinoma and Aplastic Anemia
Study Type
Interventional

2. Study Status

Record Verification Date
April 2007
Overall Recruitment Status
Unknown status
Study Start Date
May 2005 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
University of California, San Francisco
Collaborators
National Cancer Institute (NCI)

4. Oversight

5. Study Description

Brief Summary
RATIONALE: Giving low doses of chemotherapy before a donor stem cell transplant using stem cells that closely match the patient's stem cells, helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect. Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving antithymocyte globulin before transplant and cyclosporine and mycophenolate mofetil after transplant may stop this from happening. PURPOSE: This clinical trial is studying how well a donor stem cell transplant works in treating patients with hematologic cancer, metastatic kidney cancer, or aplastic anemia.
Detailed Description
OBJECTIVES: Primary Determine the treatment-related mortality (TRM) rate at 100 days in patients with hematologic malignancy, metastatic renal cell carcinoma, or aplastic anemia undergoing nonmyeloablative allogeneic stem cell transplantation using matched unrelated donors. Secondary Determine the TRM at 12 months in patients treated with this regimen. Determine the 6-month engraftment rate in patients treated with this regimen. Determine 1-year overall survival of patients treated with this regimen. OUTLINE: Nonmyeloablative preparative regimen: Patients receive fludarabine IV over 30 minutes on days -7 to -3, busulfan* IV over 6 hours on days -4 and -3, and anti-thymocyte globulin IV over 6-10 hours on days -4 to -1. NOTE: *Patients with aplastic anemia receive cyclophosphamide IV over 2 hours on days -6 to -3 instead of busulfan. Allogeneic stem cell reinfusion: Patients undergo allogeneic bone marrow or peripheral blood stem cell transplantation on day 0. Patients then receive filgrastim (G-CSF) subcutaneously daily beginning on day 7 and continuing until blood counts recover. Graft-vs-host disease (GVHD) prophylaxis: Patients receive tacrolimus orally twice daily or IV continuously beginning on day -2 and continuing for approximately for 6-12 months after transplantation. Patients also receive mycophenolate mofetil orally or IV twice daily on days 0 to 60 and methotrexate IV on days 1, 3, 6, and 11**. NOTE: **Patients with aplastic anemia receive methotrexate IV on days 1, 3, and 6 (not day 11). Donor lymphocyte infusion (DLI): After day 180, patients with no evidence of active GVHD may receive DLI. A second DLI may be infused > 8 weeks after the first in the absence of disease response or GVHD. After completion of study treatment, patients are followed periodically for at least 2 years. PROJECTED ACCRUAL: A total of 35 patients will be accrued for this study.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Chronic Myeloproliferative Disorders, Kidney Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
Keywords
adult acute myeloid leukemia with 11q23 (MLL) abnormalities, adult acute myeloid leukemia with inv(16)(p13;q22), adult acute myeloid leukemia with t(15;17)(q22;q12), adult acute myeloid leukemia with t(16;16)(p13;q22), accelerated phase chronic myelogenous leukemia, adult acute lymphoblastic leukemia in remission, adult acute myeloid leukemia in remission, atypical chronic myeloid leukemia, BCR-ABL1 negative, blastic phase chronic myelogenous leukemia, childhood acute lymphoblastic leukemia in remission, childhood acute myeloid leukemia in remission, childhood chronic myelogenous leukemia, chronic eosinophilic leukemia, primary myelofibrosis, chronic myelomonocytic leukemia, chronic neutrophilic leukemia, chronic phase chronic myelogenous leukemia, de novo myelodysplastic syndromes, essential thrombocythemia, juvenile myelomonocytic leukemia, myelodysplastic/myeloproliferative neoplasm, unclassifiable, polycythemia vera, previously treated myelodysplastic syndromes, recurrent adult acute myeloid leukemia, prolymphocytic leukemia, recurrent adult Hodgkin lymphoma, recurrent adult diffuse large cell lymphoma, recurrent adult immunoblastic large cell lymphoma, recurrent adult lymphoblastic lymphoma, recurrent/refractory childhood Hodgkin lymphoma, recurrent childhood acute lymphoblastic leukemia, recurrent childhood acute myeloid leukemia, recurrent childhood large cell lymphoma, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma, recurrent mantle cell lymphoma, refractory chronic lymphocytic leukemia, refractory multiple myeloma, relapsing chronic myelogenous leukemia, secondary acute myeloid leukemia, secondary myelodysplastic syndromes, stage II multiple myeloma, stage III chronic lymphocytic leukemia, stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage III multiple myeloma, stage IV chronic lymphocytic leukemia, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma, recurrent renal cell cancer, stage IV renal cell cancer, noncontiguous stage II grade 1 follicular lymphoma, noncontiguous stage II grade 2 follicular lymphoma, noncontiguous stage II grade 3 follicular lymphoma, recurrent adult acute lymphoblastic leukemia, childhood myelodysplastic syndromes

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Masking
None (Open Label)
Enrollment
35 (Anticipated)

8. Arms, Groups, and Interventions

Intervention Type
Biological
Intervention Name(s)
anti-thymocyte globulin
Intervention Type
Biological
Intervention Name(s)
filgrastim
Intervention Type
Biological
Intervention Name(s)
graft-versus-tumor induction therapy
Intervention Type
Biological
Intervention Name(s)
therapeutic allogeneic lymphocytes
Intervention Type
Drug
Intervention Name(s)
busulfan
Intervention Type
Drug
Intervention Name(s)
cyclophosphamide
Intervention Type
Drug
Intervention Name(s)
fludarabine phosphate
Intervention Type
Drug
Intervention Name(s)
methotrexate
Intervention Type
Drug
Intervention Name(s)
mycophenolate mofetil
Intervention Type
Drug
Intervention Name(s)
tacrolimus
Intervention Type
Procedure
Intervention Name(s)
allogeneic bone marrow transplantation
Intervention Type
Procedure
Intervention Name(s)
nonmyeloablative allogeneic hematopoietic stem cell transplantation
Intervention Type
Procedure
Intervention Name(s)
peripheral blood stem cell transplantation

10. Eligibility

Sex
All
Maximum Age & Unit of Time
74 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of 1 of the following: Aplastic anemia not responsive to immunosuppressive therapy Metastatic renal cell carcinoma Hematologic malignancy, including any of the following: Acute myeloid leukemia (AML)* not curable with chemotherapy and meeting any of the following criteria: AML with high-risk cytogenetic abnormalities (e.g., -7, -7q, -5, -5q, complex, Philadelphia chromosome-positive [Ph+]) AML evolved from prior myelodysplasia AML secondary to prior chemotherapy Failed to achieve remission In second or subsequent remission NOTE: *Marrow blasts < 10%- can be achieved by chemotherapy Myelodysplasia* with any of the following high-risk features: Adverse cytogenetics (-7, 7q, -5, -5q, complex) Excess blasts Prior conversion to AML Severe cytopenias with absolute neutrophil count < 500/mm^3 or platelet count < 20,000/mm^3 NOTE: *Marrow blasts < 10%- can be achieved by chemotherapy Acute lymphoblastic leukemia (ALL)* not curable with chemotherapy and meeting any of the following criteria: High-risk cytogenetics (Ph+, 11q23 abnormalities, monosomy 7) More than 1 induction course required to achieve remission Failed to enter remission In second or subsequent remission NOTE: *Marrow blasts < 10 % Chronic lymphocytic leukemia (CLL) with high-risk features, including any of the following: Refractory to initial or subsequent therapy Progression after initial response to therapy Prolymphocytic morphology Follicular lymphoma with any of the following high-risk features: Refractory to initial or subsequent therapy Progression after response to initial therapy Has ≥ 3 International Prognostic Index (IPI) risk factors Multiple myeloma Stage II-III disease confirmed at diagnosis or after initial progression Other lymphoma that has failed to respond to primary therapy, progressed, or recurred after prior therapy, including any of the following: Diffuse large cell lymphoma Mantle cell lymphoma Hodgkin's lymphoma Myeloproliferative disease with evidence of disease acceleration, including any of the following: Myelofibrosis Polycythemia vera Essential thrombocythemia Chronic myeloid leukemia (CML) that failed to be controlled by imatinib mesylate Disease must be stable or responding to therapy No rapid progression of malignant disease Expected time to disease progression > 12 weeks Not eligible for autologous stem cell transplantation Matched unrelated donor available 9/10 HLA matched, including HLA-A, -B, -C, -DR, and -DQ PATIENT CHARACTERISTICS: Creatinine < 2.0 mg/dL Creatinine clearance > 40 mL/min Bilirubin < 3 mg/dL Elevated total bilirubin due to Gilbert's disease allowed if direct bilirubin is normal AST < 4 times upper limit of normal Hepatitis C or B allowed provided bilirubin and AST are normal Cardiac ejection fraction > 30% DLCO > 40% of predicted Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No uncontrolled active infection requiring ongoing antibiotic treatment No poor performance status No poor organ function PRIOR CONCURRENT THERAPY: See Disease Characteristics Prior stem cell or bone marrow transplantation allowed
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Charles A. Linker, MD
Organizational Affiliation
University of California, San Francisco
Official's Role
Principal Investigator
Facility Information:
Facility Name
UCSF Comprehensive Cancer Center
City
San Francisco
State/Province
California
ZIP/Postal Code
94115
Country
United States
Facility Name
Wake Forest University Comprehensive Cancer Center
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157-1096
Country
United States

12. IPD Sharing Statement

Learn more about this trial

Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer, Metastatic Kidney Cancer, or Aplastic Anemia

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