Radiotherapy - Cerebrovascular Reactivity (RT-CVR Study)
Brain Neoplasms
About this trial
This is an interventional treatment trial for Brain Neoplasms
Eligibility Criteria
Inclusion Criteria: Patients with primary gliomas visible on MRI who are planning to receive radiotherapy or Patients with brain metastases>1cm who are planning to receive radiotherapy Karnofsky Performance Status >60 Age 18 years Patients must be willing to visit Toronto Western Hospital for at least one MRI scan prior radiotherapy Exclusion Criteria: Seizures not controlled with medications, or non compliance with prescribed anti-seizure medication Prior radiation therapy to the brain Pregnancy Unwilling or unable to co-operate with breathing maneuvers Respiratory or cardiac limitations to breathing at 20 L/min Medical contra-indications to limited hypercapnia or hypocapnia (known increased intracerebral pressure, metabolic acidosis or alkalosis) Contraindication to MRI (patients weighing>136 kgs-weight limit for the scanner tables; allergy to MR contrast agent; patients with pacemakers, cerebral aneurysm clips, shrapnel injury or implantable electronic devices not compatible with MRI) Other medical conditions deemed by the PI or associates to make the patients ineligible for protocol procedures
Sites / Locations
- University Health Network
Arms of the Study
Arm 1
Experimental
MRI for brain mets