Randomized Trial Comparing N of 1 Trials to Standard Practice to Improve Adherence to Statins in Patients With Diabetes
Diabetes, Cardiovascular Disease, Hyperlipidemia
About this trial
This is an interventional treatment trial for Diabetes focused on measuring N of 1 trial, diabetes mellitus, HMG CoA Reductase Inhibitors, cardiovascular disease
Eligibility Criteria
Inclusion Criteria: Established diagnosis of type 1 or 2 diabetes Age 18-80 years Indication for a statin by the 2003 Canadian Diabetes Association (CDA) Clinical Practice Guidelines Willingness to re-try a statin despite previous apparent intolerance Provision of signed informed consent Exclusion Criteria: Contraindication to a statin: previous rhabdomyolysis, active liver disease or unexplained persistent elevations of serum transaminases (CK, AST, ALT >three times upper limit of normal), pregnancy or lactation Impaired renal function: severe renal insufficiency (creatinine clearance <30 ml/min) Presence of a condition such as malignancy for which the one-year prognosis is poor Inability of the patient to comply with the rigorous conditions of the trial Any other condition deemed to render the study harmful to the participant
Sites / Locations
- St. Joseph's Health Care London
Arms of the Study
Arm 1
Arm 2
Experimental
Other
1
2
N of 1 trials of statin therapy
usual care