A Placebo-Controlled Study of Mirtazapine for PTSD
Anxiety, PTSD
About this trial
This is an interventional treatment trial for Anxiety focused on measuring Mirtazapine, PTSD, Veterans, antidepressant
Eligibility Criteria
Inclusion Criteria: Diagnosis of PTSD, confirmed by Mini-International Neuropsychiatric Interview (MINI) and CAPS Age 19 or older No substance abuse/dependence for the previous 4 weeks (except for nicotine and caffeine) Free of psychotropic medication for 2 weeks (except 4 weeks for fluoxetine) Clinically normal physical and laboratory examination (lab profile listed below). LFTs up to 2.5 times the normal limit will be allowed. Women of childbearing potential must be using medically approved methods of birth control (such as a condom, birth control pill, Depo-Provera, or diaphragm with spermicides) Signed informed consent Male or female, any race or ethnic origin Exclusion Criteria: Lifetime history of bipolar I, psychotic, or cognitive disorders Actively suicidal, homicidal, or psychotic History of sensitivity to mirtazapine Unstable general medical conditions Score 6 on Question #10 of MADRS regarding suicidal ideation Women who are pregnant, planning to become pregnant or breastfeed during the study
Sites / Locations
- Tuscaloosa VAMC
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Arm 1
Arm 2
Mirtazapine
Placebo