Do HMG CoA Reductase Inhibitors Affect Abeta Levels?
Alzheimer's Disease, Aging
About this trial
This is an interventional prevention trial for Alzheimer's Disease focused on measuring Alzheimer's disease, beta-amyloid, statins
Eligibility Criteria
Inclusion Criteria: Total cholesterol > 200, and/or LDL > 130 No cognitive impairment Statin-naive for at least one year Women must not be pregnant, nursing, or planning to become pregnant Exclusion Criteria: Back ailments which would hinder LP procedure Neurological disease, including stroke, Parkinson's disease, Multiple Sclerosis, uncontrolled epilepsy, history of severe head trauma Hepatic disease Renal insufficiency Unstable medical disease Severe pulmonary disease Severe cardiac disease Uncontrolled hypertension (greater than 160/90) Uncontrolled hyper/hypothyroidism History of blood clotting abnormalities or platelet abnormalities History of chronic major psychiatric disorders or presence of current major depressive disorder (by DSM-IV criteria) History of substance abuse within the past year Taking exclusionary medications
Sites / Locations
- VA Puget Sound Health Care System
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
1
2
simvastatin
pravastatin