Polyamine-free Diet to Prevent Post Surgery Hyperalgesia (PoLyDOL)
Breast Cancer, Surgery
About this trial
This is an interventional treatment trial for Breast Cancer focused on measuring polyamines, pain, breast cancer, mastectomy, post operative pain
Eligibility Criteria
Inclusion Criteria: Breast cancer (T1, T2, T3, N0, N1, M0) Age : 18 - 75 Asa 1-3 left or right tumorectomy with complete lymphadenectomy left or right complete mastectomy with complete lymphadenectomy complete lymphadenectomy within one week following simple tumorectomy informed consent signed Exclusion Criteria: inflammatory tumor requiring pre-operative radiotherapy previous history of total mastectomy or partial contralateral mastectomy chronic inflammatory disease treated by corticoids or NSAI chronic analgesic treatment anti-arrhythmic or anti-epileptic treatments morphinic treatment during the 7 days before surgery excessive alcohol consumption or addiction ketamine or neomycin contra-indication severe cardiovascular disease
Sites / Locations
- CLCC-Institut Bergonie, service d'anesthésie réanimation, 229 cours de l'Argonne
- département d'anesthésie-réanimation 3, hôpital Pellegrin
- CLCC Alexis Vautrin
- APHParis Hôpital Pitié Salpétrière - Dépt. d'anesthésie réanimation
- CLCC Réné Huguenin de Saint Cloud
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Placebo Comparator
R+ / K+
R+ / K-
R- / K+
R- /K-