Umbilical Cord Blood Infusion to Treat Type 1 Diabetes
Type 1 Diabetes Mellitus
About this trial
This is an interventional treatment trial for Type 1 Diabetes Mellitus focused on measuring Type 1 Diabetes Mellitus, Umbilical Cord, Regeneration, Insulin, Islets of Langerhans
Eligibility Criteria
Inclusion Criteria: Must have a diagnosis of T1D and have stored umbilical cord blood in an AABB and/or FACT accredited cord bank. TID diagnosis will be defined as having a clear history of polydipsia, polyphagia, polyuria, and weight loss consistent with a clinical diagnosis, diagnosis will mot be based solely upon the presence of autoantibodies. Cord blood meets all selection and testing criteria (see below). Able to complete mixed meal tolerance / glucagon stimulation test. Normal screening values for CBC, Renal function and electrolytes (BMP). Willing to comply with intensive diabetes management Exclusion Criteria: Complicating medical issues that would interfere with blood drawing or monitoring. Chronic use of steroids or other immunosuppressive agents for other conditions. Positive infectious disease markers from mothers' blood or cord at time of collection (See below for details). Any evidence of illness on planned infusion date (i.e. fever >38.5 C, vomiting, diarrhea, wheezing, or crackles).
Sites / Locations
- University of Florida
Arms of the Study
Arm 1
Active Comparator
Cord Blood
Umbilical Cord Blood