Identification and Treatment of the Liability to Develop Schizophrenia

Inclusion Criteria: Having at least one first-degree biological relative with schizophrenia and their age is between 19 and 59. Desire to participate in a medication trial. Is able to provide informed consent. Having moderate levels of negative symptoms, defined as 6 items rated 3 or higher on the Scale for the Assessment of Negative Symptoms (SANS). Scoring two or more standard deviations below normal in at least one of three cognitive domains: vigilance/working memory, long-term verbal memory, and executive functions. Scoring at least one standard deviation below normal in a second cognitive domain. Exclusion Criteria: IQ less than 80. Formal education less than 10 years. History of psychotic disorders. History of treatment with an antipsychotic medication. A substance abuse diagnosis within 6 months of diagnosis. A head injury with documented loss of consciousness exceeding 5 minutes (or subsequent cognitive deficits). A history of neurologic disease or damage. A medical condition with significant cognitive sequelae. A history of electroconvulsive treatment.