Vitamin D to Slow Progression of Knee Osteoarthritis
Osteoarthritis, Knee
About this trial
This is an interventional treatment trial for Osteoarthritis, Knee focused on measuring osteoarthritis, vitamin D, knee pain, cartilage loss, WOMAC, MRI, cartilage volume, OA, physical function, web-based, internet-based
Eligibility Criteria
Inclusion Criteria: Chronic knee discomfort based on affirmative response to the question "During the past 12 months, have you had pain, aching, or stiffness in or around your knee(s) on most days for at least one month?" WOMAC pain subscale score of at least 1 Tibiofemoral OA on posterior anterior (PA) weight-bearing semi-flexed knee radiographs with severity equivalent to Kellgren and Lawrence grade of at least 2 Clinical examination confirming knee pain or discomfort referable to the knee joint Prepared to refrain from use of glucosamine, chondroitin, MSM, DMSO, and doxycycline Pass faintness of heart trial period Exclusion Criteria: Serum 25(OH) vitamin D level greater than 80 ng/ml Use of glucosamine, chondroitin, or doxycycline within 3 months of random assignment Use of MSM, DMSO within 3 months of random assignment Use of vitamin D supplements such that the total daily dose is greater than 1,000 IU or a single source is greater than 800 IU Intra-articular joint injections (e.g., glucocorticoid or haluronic acid formulations, within 3 months of random assignment) Chronic glucocorticoid use Hypercalcemia (total serum calcium greater than 10.5 mg/dL) Hypercalcuria (spot urine calcium: creatinine ratio of 0.275 for women and 0.325 for men, corresponding to 24-hour calcium excretion of 0.30 and 0.35 g, respectively) Estimated GFR less than 30 Hyperparathyroidism (PTH greater than 65 pg/mL) History of lymphoma or sarcoidosis Reiter's syndrome Psoriatic arthritis Rheumatoid arthritis Ankylosing spondylitis Currently on treatment for tuberculosis Malabsorption disorders (e.g., advance liver disease, chronic renal disease-stage 4 or 5, Crohn's disease, Whipple's disease, celiac sprue) Serious medical conditions or impairments that, in the view of the investigator, would obstruct study participation Pregnancy Plan to permanently relocate from the region during the trial period Planned knee or hip arthroplasty during the study period Any contra-indication to having an MRI scan
Sites / Locations
- Tufts Medical Center, Division of Rheumatology
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
1
2
Participants will receive vitamin D (cholecalciferol)
Participants will receive a matched placebo