Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years (CORTAGE)
Vasculitis, Wegener's Granulomatosis, Microscopic Polyangiitis
About this trial
This is an interventional treatment trial for Vasculitis focused on measuring Systemic necrotizing vasculitides, corticosteroids; azathioprine; mycophenolate mofetil;, cyclophosphamide, Elderly patients, Randomized controlled trial
Eligibility Criteria
Inclusion Criteria: Newly diagnosed WG, MPA, PAN without HBV infection, or CSS Patients can be still be enrolled within 1 month after starting corticosteroids if prescribed according to protocol. within or after the 65th of anniversary Age ≥ 65 years Exclusion Criteria: Any cytotoxic drug within previous year Co-existence of another systemic autoimmune disease, e.g., SLE, RA Virus-associated vasculitides HIV positivity Malignancy (usually excluded unless approved by the trial coordinator) Age < 65 years Inability to give informed consent
Sites / Locations
- Hôpital Cochin
Arms of the Study
Arm 1
Arm 2
Other
Experimental
A
B
conventional treatment
reduction dose