Neurophysiology of Task-Specificity of Focal Hand Dystonia
Focal Dystonia
About this trial
This is an observational trial for Focal Dystonia focused on measuring Focal Hand Dystonia, Motor Planning, Transcranial Magnetic Stimulation (TMS), MRI (Magnetic Resonance Imaging), FHD, Writer's Cramp, Healthy Volunteer, HV
Eligibility Criteria
INCLUSION CRITERIA: Patients: Age over 18 years Presence of FHD, specifically writer's cramp Healthy volunteers: Age over 18 years Absence of dystonia or other neurologic condition EXCLUSION CRITERIA: Patients and Healthy volunteers: Concurrent medical, surgical, neurologic or psychiatric condition Taking medications which include antidepressants, anxiolytics, anticonvulsants, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines Received botulinum toxin injection within 3 months of starting the protocol Presence of pacemaker, implanted medical pump, metal plate or metal object in skull or eye History of seizure disorder For healthy volunteers undergoing MRI, subjects with implanted devices such as pacemakers, medication pumps or defibrillators, metal in the cranium except mouth, intracardiac lines, history of shrapnel injury or any other condition/device that may be contraindicated or prevent the acquisition of MRI and/or current pregnancy A serious medical illness which prevents them from lying flat for up to 60 minutes Claustrophobia (a fear of tight spaces), which prevents them from lying still in a tight or small space for up to 60 minutes
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike