Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia (CLL) That Did Not Respond to Fludarabine, CLL With Autoimmune Haemolytic Anemia (AIHA) or Richter's Transformation (RT)
Chronic Lymphocytic Leukemia
About this trial
This is an interventional treatment trial for Chronic Lymphocytic Leukemia focused on measuring refractory chronic lymphocytic leukemia, stage I chronic lymphocytic leukemia, stage II chronic lymphocytic leukemia, stage III chronic lymphocytic leukemia, stage IV chronic lymphocytic leukemia
Eligibility Criteria
DISEASE CHARACTERISTICS: Confirmed diagnosis of previously treated chronic lymphocytic leukemia (CLL) meeting the following criteria: Binet stage B (Rai stages I and II) or Binet stage C (Rai stages III and IV) disease Rapid disease progression, symptomatic enlarged lymph nodes, or severe B-cell symptoms CLL with autoimmune hemolytic anemia allowed Richter transformation allowed PATIENT CHARACTERISTICS: Life expectancy > 3 months ECOG performance status 0-3 No severe organ dysfunction No other prior or concurrent neoplasms PRIOR CONCURRENT THERAPY: No more than 4 prior chemotherapy regimens
Sites / Locations
- Kreiskrankenhaus
- DIAKO Ev. Diakonie Krankenhaus gGmbH
- Medizinische Universitaetsklinik I at the University of Cologne
- Universitaetsklinikum Essen
- Gemeinschaftspraxis Fuer Innere Medizin, Hematologie Und Onkologie
- St. Marien Hospital - Katholisches Krankenhaus Hagen gGmbH
- Allgemeines Krankenhaus Hagen
- Praxis fur Innere Medizin - Hamburg
- Asklepios Klinik St. Georg
- Marienhospital at Ruhr University Bochum
- Clinic for Bone Marrow Transplantation and Hematology and Oncology
- Internistische Gemeinschaftspraxis - Kassel
- Internistische Onkologische Praxis - Kronach
- Klinikum der Universitaet Muenchen - Grosshadern Campus
- Klinikum Oldenburg
- Marienhospital Stuttgart
- Haematologische Praxis
- Medizinische Poliklinik, Universitaet Wuerzburg