Thiotepa and Radiation Therapy in Treating Young Patients With Newly Diagnosed Malignant Brain Tumors

Thiotepa and Radiation Therapy in Treating Young Patients With Newly Diagnosed Malignant Brain Tumors

Continuous Infusion Thiotepa in High Grade Astrocytic Tumors of Childhood and Adolescence A UKCCSG Phase II Study Involving the Brain Tumour and New Agent Groups

RATIONALE: Drugs used in chemotherapy, such as thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving chemotherapy and radiation therapy after surgery may kill any tumor cells that remain after surgery. PURPOSE: This phase II trial is studying how well thiotepa works together with radiation therapy in treating young patients with newly diagnosed malignant brain tumors.

OBJECTIVES: Primary Determine tumor response to adjuvant thiotepa followed by radiotherapy in pediatric patients with newly diagnosed malignant astrocytic tumors. Secondary Determine the acute and chronic toxicity of thiotepa in these patients. Determine the variability in thiotepa metabolism by measuring plasma and cerebrospinal fluid pharmacokinetics of thiotepa and tepa in these patients. Develop a phase II study framework model, to determine the chemosensitivity to new, single-agent regimens in the treatment of high-grade (malignant) astrocytic tumors, including anaplastic astrocytoma, glioblastoma, giant cell glioblastoma, and gliosarcoma. Determine the incidence of distant neuraxial metastases in patients at the time of relapse. Determine the 1-year disease-free survival rate in patients treated with this regimen. OUTLINE: This is a multicenter study. Patients are stratified by age (3-15 vs 16-20 years of age). Chemotherapy: Patients receive thiotepa IV continuously over 168 hours on days 1-7. Treatment repeats every 28 days for up to 2 courses. Patients then proceed to radiotherapy after blood counts recover. Radiotherapy: Patients undergo external-beam radiotherapy once daily, 5 days a week, for approximately 6 weeks. Post-radiation chemotherapy: Patients with complete, partial, or objective response, or stable disease after 2 courses of thiotepa may receive thiotepa alone for up to 8 more courses at the discretion of the treating physician. After completion of study treatment, patients are followed periodically. PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

DISEASE CHARACTERISTICS: Histologically confirmed diagnosis of 1 of the following high-grade (malignant) astrocytic tumors: Anaplastic astrocytoma Glioblastoma Giant cell glioblastoma Gliosarcoma Any anatomical site except brain stem Newly diagnosed disease Has undergone tumor biopsy or surgical resection within the past 2 weeks Patients with post-operative residual disease (grade III or IV) are eligible Post-operative imaging of tumor within 72 hours of surgery Patients with no imageable post-operative disease are not eligible No neurological deterioration within 3 days of study treatment Increasing requirement for steroids to control symptoms of intracranial pressure is considered evidence of neurological deterioration PATIENT CHARACTERISTICS: Lansky play score 40-100% Absolute neutrophil count > 1,000/mm^3 Platelet count > 100,000/mm^3 Creatinine ≥ 1.5 times upper limit of normal PRIOR CONCURRENT THERAPY: See Disease Characteristics No prior chemotherapy or radiotherapy