Short-Term Versus Long-Term Treatment for Severe Premenstrual Syndrome (PMS)
Premenstrual Syndrome
About this trial
This is an interventional treatment trial for Premenstrual Syndrome focused on measuring PMS, PMDD, sertraline, antidepressant, extended treatment, relapse
Eligibility Criteria
Inclusion Criteria: Women with PMS for at least 1 year. Ages 18-45 years Regular menstrual cycles in normal range (22-36 days) for at least 6 months In general good health as determined by physical examination and blood tests. Evidence of ovulation using a urine test. Meeting stated criteria for PMS. Signed informed consent. Exclusion Criteria: Any prescription, over-the-counter, herbal or non-medical therapies for PMS. Use of psychotropic medications that cannot be stopped for the duration of the study. Other current psychiatric diagnoses as determined by SCID interview. Alcohol or substance abuse/dependence or suicide attempt within the past 12 months; lifetime history of psychosis, bipolar disorder and clearly identifiable severe personality disorder. Hysterectomy, symptomatic endometriosis, irregular menstrual cycles,any severe or unstable medical illness. Lack of medically-approved contraception, currently pregnant, intention to become pregnant or breast feeding.
Sites / Locations
- Department of Obstetrics/Gynecology, University of Pennsylvania, School of Medicine