Carotid Artery Stenting With Protection Registry

Inclusion Criteria: Age greater than 18 and less than 90 Symptomatic as evidenced by transient ischemic attack or non-disabling stroke in the hemisphere supplied by the target vessel within 180 days of procedure. Must have anatomic stenosis greater than 70% by ultrasound or angiography performed in previous 30 days Asymptomatic patients with a stenosis greater than 80% by ultrasound or angiography performed in previous 30 days Patient has no childbearing potential or has negative pregnancy tests within one week prior to procedure. Patient and patient's physician agree to have the patient return for all the required clinical contacts following study enrollment Patient signs informed consent Patient has been excluded from other multi-institutional trials Exclusion Criteria: Patient has evolving stroke or intracranial hemorrhage Allergy to trial required medications Active bleeding diathesis or coagulopathy, or will refuse blood transfusions History of major ipsilateral stroke with sufficient atrophy to increase risk of procedure associated bleed Severe dementia Previous intracranial hemorrhage or brain surgery within the past twelve months Patient has any condition that precludes angiography or would make a percutaneous procedure unsafe Patient or family inability to understand or cooperate with study procedures Recent GI or remote bleed that would interfere with anti-plate therapy Severe vessel tortuosity or calcification that would preclude introduction of guiding catheter, guiding sheath, or stent placement Extensive diffuse atherosclerotic disease involving the arch or common carotid that would preclude safe introduction of catheters and sheaths for endovascular therapy Intraluminal filling defect Intracranial aneurysm greater than 6 mm, AVM, or other intracranial vascular abnormality that would preclude safe intravascular intervention