Safety and Efficacy of Repeated Intravitreal Administration of Vascular Endothelial Growth Factor (VEGF) Trap in Patients With Wet Age-Related Macular Degeneration (AMD)

Inclusion Criteria: Subfoveal CNV secondary to AMD. Central retinal (including lesion) thickness ≥ 300 µm as measured by Optical Coherence Tomography (OCT). Early Treatment of Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity of 73 letters to 34 letters. Exclusion Criteria: History of any vitreous hemorrhage within 4 weeks prior to Day 1. Aphakia. Significant subfoveal atrophy or scarring. Prior treatment with the following in the study eye: Subfoveal thermal laser therapy. Submacular surgery or other surgical intervention for the treatment of AMD. Extrafoveal laser coagulation treatment within 12 weeks prior to Day 1. Photodynamic therapy (PDT) within 12 weeks prior to Visit 2 (Day 1). Pegaptanib sodium (Macugen) within 8 weeks of Visit 2 (Day 1). Juxtascleral steroids or anecortave acetate within 24 weeks (6 months) prior to Visit 2 (Day 1). Intravitreal administration of triamcinolone acetonide or other steroids within 24 weeks prior to Visit 2 (Day 1), unless no visible residue of drug substance can be seen in the vitreous cavity using indirect ophthalmoscopy. Prior systemic or intravitreal treatment with VEGF Trap, ranibizumab (Lucentis) or bevacizumab (Avastin). Presence of any other condition or laboratory abnormality, which, in the opinion of the Investigator, would interfere with the assessment of disease status/progression or jeopardize the patient's appropriate participation in this Phase II study.