Comparison of Sirolimus and Azathioprine in Lung Transplantation
Delayed Graft Function, Acute Graft Rejection
About this trial
This is an interventional prevention trial for Delayed Graft Function focused on measuring Rejection in lung transplant
Eligibility Criteria
Inclusion Criteria: Lung transplant recipients between the age of 18 and 65 years of age. Females who are capable of becoming pregnant must have a negative pregnancy test prior to consent. (Females of childbearing potential must be using a medically acceptable method of birth control for the duration of the study.) All patients must be able to give written informed consent. Exclusion Criteria: White blood cell count (WBC) < 4.0/mm3 Platelet count < 100,000/mm3 Severe hypercholesterolemia (> 350 mg/dl) or hypertriglyceridemia (> 500 mg/dl) Uncontrolled systemic infection at the time of consent. Previous organ transplant Treatment with a drug within the last 30 days that has not received regulatory approval at the time of study entry or for the duration of the study (3 years). Use of maintenance immunosuppression other than daclizumab, tacrolimus, azathioprine, or prednisone prior to randomization.
Sites / Locations
- University of Chicago
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Azathioprine
Sirolimus
(tacrolimus,azathioprine/prednisone)
tacrolimus/sirolimus/prednisone