Steroids for Corneal Ulcers Trial (SCUT)
Corneal Ulcer, Eye Infections, Bacterial
About this trial
This is an interventional treatment trial for Corneal Ulcer focused on measuring Bacterial Infections, Eye Diseases, Bacterial Keratitis, Visual Acuity
Eligibility Criteria
Inclusion Criteria At Presentation: Presence of a corneal ulcer at presentation At Enrollment: Presence of bacteria on blood or chocolate agar culture Antibiotic given for > 48 hours The patient must be able to verbalize a basic understanding of the study after it is explained to the patient, as determined by physician examiner. This understanding must include a commitment to return for f/u visits. Appropriate consent Exclusion Criteria At Presentation: Overlying epithelial defect < 0.75 mm at its greatest width at presentation Corneal perforation or impending perforation Evidence of fungus on KOH, Giemsa at time of presentation Evidence of acanthamoeba by stain Evidence of herpetic keratitis by history or exam Corneal scar not easily distinguishable from current ulcer Use of a topical steroid in the affected eye during the course of the present ulcer, including use after the symptoms of the ulcer started but before presentation Use of systemic prednisolone during the course of the present ulcer Age less than 16 years (before 16th birthday) Bilateral ulcers Previous penetrating keratoplasty Pregnancy (by history or urine test) Immediate steroid use necessary due to surgery or other condition At Enrollment: Evidence of fungus on culture at time of enrollment Absence of bacteria on blood or chocolate agar culture Best spectacle-corrected vision worse than 6/60 in the fellow eye Corneal perforation or descemetocele Known allergy to study medications (steroid or preservative) No light perception in the affected eye Not willing to come to follow-up visits Not willing to participate
Sites / Locations
- Proctor Foundation, UCSF
- Dartmouth Hitchcock Medical Center
- Aravind Eye Hospital
- Aravind Eye Hospital
- Aravind Eye Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
1
2