Long-Term Motor Learning in Focal Hand Dystonia
Focal Hand Dystonia
About this trial
This is an observational trial for Focal Hand Dystonia focused on measuring Writer's Cramp, Electroencephalogram (EEG), Transcranial Magnetic Stimulation (TMS), Fine Motor Skills, Focal Hand Dystonia, Writer Cramp, Healthy Volunteer, HV
Eligibility Criteria
INCLUSION CRITERIA: Healthy volunteers: Age 18 years and older Right-hand dominant (Edinburgh Handedness Quotient greater than 60) Able to provide consent for the protocol Patients: Age 18 years and older Right hand dominant (Edinburgh Handedness Quotient greater than 60) Idiopathic focal hand dystonia in right hand Able to provide consent for the protocol EXCLUSION CRITERIA: Subjects with other medical, surgical, neurologic or psychiatric conditions If participants are taking certain centrally acting medications (like antidepressants, anxiolytics/neuroleptics, anticonvulsants, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines) may not be eligible to participate in this study. The presence of a cardiac pacemaker, an implanted medical pump, a metal plate or metal object in skull or eye is contraindications for TMS application. Patients with seizure disorder or epilepsy Subjects without the capacity to give informed consent If participation in the study would, in the opinion of the investigators, cause undue risk or stress for reasons such as excessive fatigue, general frailty, or excessive apprehension Patients: Subjects with any abnormal findings on neurological examination (except right hand), and general physical examination Secondary hand dystonia Healthy volunteers: Subjects with any abnormal findings on neurological examination and general physical examination Subjects who have learned to play the piano or any other keyboard instrument in the past. Subjects who have jobs or are involved in daily activities that demand skilled, fine-finger movements
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike