Paroxetine Treatment in Outpatients With Comorbid PTSD and Substance Dependence
PTSD
About this trial
This is an interventional treatment trial for PTSD focused on measuring Substance Abuse, Trauma, Dependence
Eligibility Criteria
Inclusion Criteria: Men and women aged 18 to 65 Outpatients who meet DSM-IV criteria for PTSD, chronic subtype, based on CAPS-1 Must have a minimum score of 50 on the CAPS-2 at Baseline Must meet DSM-IV criteria for a substance dependence disorder in the last 3 months (excluding caffeine and nicotine) Must be able to read English Must give written informed consent Exclusion Criteria: Individuals with a primary psychiatric disorder other than PTSD Individuals with an uncontrolled neurologic condition that could confound the results of the study (e.g. seizure disorder) Individuals with an uncontrolled medical condition that may adversely affect the conduct of this trial or jeopardize subject safety Concomitant use of other psychotropic medications (intermittent use of diphenhydramine and zolpidem will be allowed during the study) see concommitant meds on page 5 of the protocol Women of childbearing potential who are pregnant, lactating or refuse to use adequate forms of birth control Individuals who have failed an adequate trial of paroxetine in the past Current suicidal or homicidal risk Currently receiving trauma-specific psychotherapy Individuals taking any herbal psychoactive treatments (e.g. St. John's Wart) Individuals engaged in compensation litigation whereby personal gain would be achieved from prolonged symptoms of PTSD or any other psychiatric disorder Individuals, who in the investigator's opinion would be unable to comply with study procedures or assessments
Sites / Locations
- Medical University of South Carolina