Oral Versus Injectable Risperidone for Treating First-Episode Schizophrenia
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring Schizoaffective Disorder, Depressed Type, Schizophreniform Disorder, First-episode Schizophrenia, Injectable Risperidone
Eligibility Criteria
Inclusion Criteria: DSM-IV diagnosis of schizophrenia, schizoaffective disorder (depressed type), or schizophreniform disorder First major episode of psychotic symptoms occurred within 2 years prior to study entry Participant in the UCLA Center for Neurocognition and Emotion in Schizophrenia Exclusion Criteria: Neurological disorder or injury (e.g., encephalitis, epilepsy, traumatic brain injury) Mental retardation (e.g., premorbid IQ less than 70) Significant alcohol or substance abuse within 6 months prior to study entry Inability to complete research measures in English Any condition that may make risperidone use medically inadvisable
Sites / Locations
- Semel Institute for Neuroscience and Human Behavior at UCLA
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Long-acting injectible risperidone
Oral risperidone
Participants who are randomly assigned to this arm will be administered the long-acting injectible form of risperidone (Risperdal Consta) every two weeks, plus group skills training and case management, for 12 months.
Participants who are randomly assigned to this arm will be treated with the oral version of risperidone (Risperdal) daily, plus group skills training and case management, for 12 months.