Cellular Adoptive Immunotherapy in Treating Patients With Glioblastoma Multiforme
Brain and Central Nervous System Tumors
About this trial
This is an interventional treatment trial for Brain and Central Nervous System Tumors focused on measuring adult glioblastoma, adult gliosarcoma, adult giant cell glioblastoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of primary malignant glioblastoma multiforme (i.e., grade IV anaplastic astrocytoma) Primary treatment (surgery, radiation, and/or chemotherapy) has been completed Candidate for surgery and willing to undergo craniotomy No progressive or recurrent disease No residual disease that requires reoperation, additional gamma therapy, or other modality PATIENT CHARACTERISTICS: ECOG performance status (PS) 0-2 OR Karnofsky PS 70-100% (i.e., if symptomatic, bedridden < half of a waking day) Life expectancy ≥ 2 months Not pregnant Negative pregnancy test U.S. residents only No hematopoietic, hepatic, renal, cardiovascular, or pulmonary laboratory values or other medical circumstances that would preclude surgery or aldesleukin therapy No serious concurrent medical or psychiatric illness that would preclude informed consent or study treatment PRIOR CONCURRENT THERAPY: See Disease Characteristics At least 4 weeks since prior anticancer therapy and recovered Prior stereotactic or gamma knife radiosurgery allowed
Sites / Locations
- Hoag Cancer Center at Hoag Memorial Hospital Presbyterian