Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma
Childhood Malignant Fibrous Histiocytoma of Bone, Sarcoma
About this trial
This is an interventional treatment trial for Childhood Malignant Fibrous Histiocytoma of Bone focused on measuring childhood synovial sarcoma, nonmetastatic childhood soft tissue sarcoma, childhood alveolar soft-part sarcoma, childhood angiosarcoma, childhood epithelioid sarcoma, childhood fibrosarcoma, childhood leiomyosarcoma, childhood liposarcoma, childhood neurofibrosarcoma, localized childhood malignant fibrous histiocytoma of bone, childhood malignant hemangiopericytoma, dermatofibrosarcoma protuberans, chondrosarcoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed synovial sarcoma or adult-type soft-tissue sarcoma Adult-type soft tissue sarcoma includes any of the following: Fibrosarcoma (adult-type) No infantile fibrosarcoma Malignant peripheral nerve sheath tumor Malignant schwannoma Neurofibrosarcoma Epithelioid sarcoma Leiomyosarcoma Clear cell sarcoma Liposarcoma Alveolar soft-part sarcoma Malignant fibrous histiocytoma Hemangiopericytoma Angiosarcoma Dermatofibrosarcoma protuberans Mesenchymal chondrosarcoma No borderline tumors (e.g., hemangioendothelioma) No small round cell tumors (e.g., extraosseous Ewing's sarcoma/primitive neuroectodermal tumor or desmoplastic small round cell tumor) Post-irradiation soft-part sarcomas allowed Diagnostic surgery performed within the past 8 weeks (for patients who require adjuvant chemotherapy) No evidence of metastatic disease Involved locoregional lymph nodes are allowed PATIENT CHARACTERISTICS: No prior malignancy No pre-existing illness precluding study treatment* Normal renal function (nephrotoxicity grade 0-1)* No history of cardiac disease* Normal shortening fraction (> 28%)* Ejection fraction > 47%* NOTE: * For patients who require adjuvant chemotherapy PRIOR CONCURRENT THERAPY: No prior cancer treatment except primary surgery
Sites / Locations
- St. Anna Children's HospitalRecruiting
- Clinique de l'EsperanceRecruiting
- Rigshospitalet - Copenhagen University HospitalRecruiting
- Institut Curie HopitalRecruiting
- Our Lady's Hospital for Sick Children CrumlinRecruiting
- Vall d'Hebron University HospitalRecruiting
- Uppsala University HospitalRecruiting
- University Children's HospitalRecruiting
- Birmingham Children's HospitalRecruiting
- Institute of Child Health at University of BristolRecruiting
- Addenbrooke's HospitalRecruiting
- Leeds Cancer Centre at St. James's University HospitalRecruiting
- Leicester Royal InfirmaryRecruiting
- Royal Liverpool Children's Hospital, Alder HeyRecruiting
- Middlesex HospitalRecruiting
- Great Ormond Street Hospital for ChildrenRecruiting
- Royal Manchester Children's HospitalRecruiting
- Sir James Spence Institute of Child Health at Royal Victoria InfirmaryRecruiting
- Queen's Medical CentreRecruiting
- Oxford Radcliffe HospitalRecruiting
- Children's Hospital - SheffieldRecruiting
- Southampton General HospitalRecruiting
- Royal Marsden - SurreyRecruiting
- Royal Belfast Hospital for Sick ChildrenRecruiting
- Royal Aberdeen Children's HospitalRecruiting
- Royal Hospital for Sick ChildrenRecruiting
- Royal Hospital for Sick ChildrenRecruiting
- Childrens Hospital for WalesRecruiting