Rituximab and Combination Chemotherapy in Treating Patients With Primary Central Nervous System Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring primary central nervous system non-Hodgkin lymphoma
Eligibility Criteria
Inclusion criteria: Histologically confirmed non-Hodgkin's lymphoma by brain biopsy Patients with inconclusive biopsy or patients who are not candidates for biopsy must have typical CT scan or MRI of the brain AND meet ≥ 1 of the following criteria: Positive cerebrospinal fluid cytology for lymphoma OR a monoclonal lymphoid population as defined by cell surface markers or immunoglobulin gene rearrangement studies Biopsy-proven involvement of the vitreous or uvea if cells are apparent in the posterior chamber or vitreous by ophthalmological examination Bideminsionally measurable disease, defined as contrast-enhancing tumor ≥ 1 cm by pretreatment MRI/CT scan Meningeal or vitreous involvement constitutes evaluable but not measurable disease If an excisional, rather than a needle biopsy was done, measurable disease must be present on a postoperative scan (not a PET-CT scan) ECOG performance status 0-3 Absolute granulocyte count ≥ 1,500/mm³ Platelet count ≥ 100,000/mm³ Bilirubin ≤ upper limit of normal (ULN) SGOT ≤ 2.0 times ULN Creatinine clearance ≥ 50 mL/min Negative pregnancy test Fertile patients must use effective contraception Exclusion criteria: Pregnant or nursing HIV-1 positivity Other malignancy within the past 5 years except basal cell skin cancer or any carcinoma in situ Pre-existing immunodeficiency Hepatitis B surface antigen positivity Systemic lymphoma (as determined by pre-registration CT scans and physical examination) Prior chemotherapy or radiotherapy for primary central nervous system lymphoma Prior organ or bone marrow transplantation
Sites / Locations
- Stanford Cancer Center
- University of Florida Shands Cancer Center
- Mayo Clinic - Jacksonville
- John H. Stroger, Jr. Hospital of Cook County
- Hinsdale Hematology Oncology Associates
- McFarland Clinic, PC
- Siouxland Hematology-Oncology Associates, LLP
- Mercy Medical Center - Sioux City
- St. Luke's Regional Medical Center
- Hospital District Sixth of Harper County
- Cancer Center of Kansas, PA - Chanute
- Cancer Center of Kansas, PA - Dodge City
- Cancer Center of Kansas, PA - El Dorado
- Cancer Center of Kansas - Fort Scott
- Cancer Center of Kansas-Independence
- Cancer Center of Kansas, PA - Kingman
- Lawrence Memorial Hospital
- Southwest Medical Center
- Cancer Center of Kansas, PA - Newton
- Cancer Center of Kansas, PA - Parsons
- Cancer Center of Kansas, PA - Pratt
- Cancer Center of Kansas, PA - Salina
- Cancer Center of Kansas, PA - Wellington
- Associates in Womens Health, PA - North Review
- Cancer Center of Kansas, PA - Medical Arts Tower
- Cancer Center of Kansas, PA - Wichita
- CCOP - Wichita
- Via Christi Cancer Center at Via Christi Regional Medical Center
- Wesley Medical Center
- Cancer Center of Kansas, PA - Winfield
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Borgess Medical Center
- West Michigan Cancer Center
- Bronson Methodist Hospital
- Fairview Ridges Hospital
- Mercy and Unity Cancer Center at Mercy Hospital
- Fairview Southdale Hospital
- Mercy and Unity Cancer Center at Unity Hospital
- Hutchinson Area Health Care
- HealthEast Cancer Care at St. John's Hospital
- Minnesota Oncology Hematology, PA - Maplewood
- Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
- Hennepin County Medical Center - Minneapolis
- Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
- Mayo Clinic Cancer Center
- CCOP - Metro-Minnesota
- Park Nicollet Cancer Center
- Regions Hospital Cancer Care Center
- United Hospital
- St. Francis Cancer Center at St. Francis Medical Center
- Ridgeview Medical Center
- Minnesota Oncology Hematology, PA - Woodbury
- Summa Center for Cancer Care at Akron City Hospital
- Barberton Citizens Hospital
- Aultman Cancer Center at Aultman Hospital
- MetroHealth Cancer Care Center at MetroHealth Medical Center
- Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
- Geisinger Cancer Institute at Geisinger Health
- Geisinger Hazleton Cancer Center
- Fox Chase Cancer Center - Philadelphia
- Geisinger Medical Group - Scenery Park
- Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
- Medical X-Ray Center, PC
- Sanford Cancer Center at Sanford USD Medical Center
- Vanderbilt-Ingram Cancer Center
- West Virginia University Health Sciences Center - Charleston
- Gundersen Lutheran Center for Cancer and Blood
- University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Arms of the Study
Arm 1
Experimental
Rituximab + standard chemotherapy
Rituximab + high dose methotrexate, leucovorin, vincristine, procarbazine, dexamethasone, and cytarabine. Patients with meningeal involvement will receive additional methotrexate and leucovorin.