Effect of Brain Lesion Severity on Treatment Response in Late-Life Depression
Depression
About this trial
This is an interventional treatment trial for Depression focused on measuring Late-Life Depression
Eligibility Criteria
Inclusion Criteria: DSM-IV of major depressive disorder (MDD) Score of greater than 20 on the MADRS (score of greater than 17 for atypical depression) Score of greater than 20 on the Mini Mental State Examination (MMSE) Exclusion Criteria: Any condition that may make having an MRI medically inadvisable Any severe or unstable medical conditions Any known primary neurological disorders, including history of stroke Any other simultaneous Axis I disorder History of substance or alcohol abuse disorder within 6 months prior to study entry Currently at risk for suicide History of failed prior adequate trials of two antidepressants for the current depressive episode History of failed prior adequate trial of sertraline Current use of any other psychoactive medications (medication washout will be required)
Sites / Locations
- Washington University in St. Louis
- Duke University Medical Center