Examination of Protective Factors Against Severe Malaria
Malaria, Severe Malaria
About this trial
This is an observational trial for Malaria focused on measuring Sickle Trait, Fetal Hemoglobin, Hemoglobin C, Beta-Thalassemia, Artesunate-Amodiaquine
Eligibility Criteria
INCLUSION CRITERIA: All malaria patients enrolled in the case-control study will be less than 11 years old. Uncomplicated malaria: Axillary temperature greater than 37.5 degrees Celsius or history of fever, signs and symptoms of malaria (e.g. headache, body aches, malaise), asexual parasite density less than 500,000 per microliter of blood, no criteria of severe malaria (see next paragraph), and no other etiologies of febrile illness (e.g. respiratory tract infection, cellulitis) on clinical examination. Severe malaria: Asexual parasite density greater than or equal to 100,000/uL or parasitemia of any density plus any one of the following: coma (defined as Blantyre coma score less than or equal to 2), convulsions (witnessed by investigator), severe prostration, severe anemia (hemoglobin less than 5 g/dL), respiratory distress, hypoglycemia (serum glucose less than 40 mg/dL), jaundice/icterus, shock (systolic blood pressure less than 50 mmHg, rapid pulse, cool extremities), cessation of eating and drinking, repetitive vomiting. EXCLUSION CRITERIA: Patients who are parasitemic yet are found by clinical examination to have another etiology of febrile illness (e.g., respiratory tract infection, cellulitis) will not be formally enrolled into the protocol, but may be treated for both malaria and their coexisting infection by the study team.
Sites / Locations
- Malaria Research and Training Center