The Efficacy and Safety of Desloratadine With Levocetirizine in Treatment of Chronic Idiopathic Urticaria
Chronic Idiopathic Urticaria, Urticaria
About this trial
This is an interventional treatment trial for Chronic Idiopathic Urticaria focused on measuring Chronic Idiopathic Urticaria, Desloratadine, Denosin, Levocetirizine
Eligibility Criteria
Inclusion Criteria: The subject or deputy has read or been informed and signed the Informed Consent Agreement and the subject will be willing and able to participate in the study. The subject ≥ 12 years old. The subject with documented signs and symptoms of CIU for 6 weeks or more. The subject has to have a CIU flare for 3 weeks or more before screening, with urticarial lesions visible 3 days or more per week. The overall severities of CIU have to be at least mild to moderate at screening and baseline, subjects have to have at least mild to moderate pruritus, hives have to be apparent at screening, and subjects have intention to treatment. Exclusion Criteria: The subject has received any histamine, corticosteroids, ketotifene, systemic antibiotics, nedocromil, sodium cromoglycate or thyroxin drug within 7 days preceding randomization. The subject has received any other investigational drug within one month preceding randomization. The subject has previous non-response to antihistamines. The subject has previous allergy or allergies of desloratadine or levocetirizine. The subject need for long-term corticosteroids treatment (including inhaled, oral and topical dosage). The subject has autoimmune diseases. The subject's urticaria is physical urticaria, cholinergic urticaria or angioedema. The subject is in the situation of pregnancy or breastfeeding. The subject has liver dysfunction (AST ≧ 3 times normal range; ALT ≧ 3 times normal range ) or renal dysfunction (Creatinine ≧ 3.0mg/dl ). The subject is unable to keep an accurate diary of disease symptoms. The subject has significant concomitant illness, which, in the opinion of the investigator, will interfere with the evaluation of the study medications.
Sites / Locations
- Department of Dermatology National Taiwan University HospitalRecruiting