Prevention of Radiation Pneumonitis After Three-dimensional Conformal Radiation Therapy (3D-CRT) in Patients With Non-small-cell Lung Cancer

Inclusion Criteria: Non-metastatic cytologically or histologically proven non-small-cell lung cancer (NSCLC) Operated NSCLC patients requiring post-surgical irradiation or non-operated NSCLC patients requiring curative irradiation Conformational thoracic radiotherapy with curative intent Age >= 18 Complete functional respiratory evaluation (FRE) performed less than 2 months before inclusion, demonstrating a maximum expiratory flow-volume/second > 1 l (in case surgery, the FRE must have been realized in the post-surgery period) Thoracic CT-scan performed less than 2 months before inclusion for non-operated patient PET-scan performed less than 2 months before inclusion for non-operated patient Performance status (PS) ECOG <= 1 Possible training on breath holding technique Female patients of childbearing potential: effective method of contraception necessary Mandatory affiliation with a social security system Written, signed, informed consent Exclusion Criteria: Small-cell lung cancer Metastatic disease Infiltrating pulmonary disease Previous thoracic irradiation Indication of irradiation with palliative intent Previous or concurrent primary malignancies at other sites (except basocellular skin cancer or cervical cancer in situ or complete remission for more than 5 years) Life expectancy < 6 months Patient understanding incompatible with the breath-hold technique (patients with major presbycusis are not eligible) Pregnant or lactating woman Patient included in another clinical trial Follow-up difficult Patient deprived of freedom