Postconditioning in Primary PCI and Direct Stenting
Myocardial Infarction
About this trial
This is an interventional treatment trial for Myocardial Infarction focused on measuring Myocardial Infarction, Primary PCI, Postconditioning, MRI
Eligibility Criteria
Inclusion Criteria: Patient is > 21 years of age and provides informed consent. Evidence of AMI as indicated by signs and symptoms. Diagnosis of ST-segment elevation AMI will be based on chest pain for >30 minutes and ST-segment elevation of >1mV in 2 limb lead or >2mV in 2 anterior leads contiguous leads on the 12-lead ECG. Eligible to undergo primary PCI. Symptom duration is < 6 hours prior to primary PCI. Angiographic: The target lesion in the infarct related artery (IRA) should be occluded (TIMI). Angiographic: The target lesion in the proximal or middle segment of a native major coronary artery (LAD, RCA or dominant CX). Angiographic: The target lesion should be suitable for PTCA or stenting. Angiographic: The IRA occlusion will be successfully opened by stenting with TIMI 2-3 Exclusion Criteria: Unwillingness to participate. Prior Acute MI Cardiac arrest or Killip score III-IV Women with known pregnancy. Active significant bleeding. Known allergy for aspirin, ticlopidine and clopidogrel, or heparin. Chronic renal failure with creatinine > 2 mg/dl Other medical illness associated with limited life expectancy or that may cause the patient to be non-compliant with the protocol. Current participation in other trials using investigational drugs or devices. Contraindications to MRI including: arrythmias, cardiac pacer, brain aneurysm clips, cochlear implants, nerve stimulator.
Sites / Locations
- Sheba Medical Center