A Randomized Phase I Study of a Hepatitis B Antigen Combined With IMP321

Inclusion Criteria: able to give a written informed consent ; healthy male volunteers aged between 18 and 40 years and post-menopausal healthy women aged between 18 and 55 years; with body mass index (weight/height²) in the range 18 to 30 kg/m²; registered with the French Social Security in agreement with the French Law (Huriet Law : N° 88.1138 - 20.12.88) on biomedical experimentation; able to comply with protocol requirements, including overnight stays, blood and urine sample collections as defined in the protocol; not previously vaccinated for Hepatitis B. Exclusion Criteria: who on direct questioning and physical examination have evidence of any clinically significant acute or chronic disease, including known or suspected HIV, HBV and HCV infection ; with any clinically significant abnormality following review of pre-study laboratory tests and full physical examination ; who have received any experimental drug within the exclusion period defined in the National Register for Healthy Volunteers of the French Ministry of Health ; who forfeit their freedom by administrative or legal award or who were under guardianship ; unwilling to give their informed consent ; who present a positive laboratory test for Hepatitis B surface antigen (HbsAg), HBc antibodies, HIV 1 and 2 antibodies and HCV antibodies ; who have a history of allergy or intolerance to the study drug ; who had a history of serious allergy, asthma, allergic skin rash or sensitivity to any drug ; who are known or suspected alcohol or drug abusers ; who present a positive laboratory test for urine drug screening (opiates, barbiturates, amphetamine, cannabis) ; who undergo surgery or have donated blood within 1 month prior to the start of the study ; who have taken any prescribed or over the counter drug (including antacid drug), with the exception of paracetamol (up to 3 g per day) within 1 week prior to the first dose administration ; who receive any drug known to affect hepatic metabolism like cimetidine, ketoconazole, fluconazole, itraconazole, phenytoin, rifampicin, rifabutin within 1 month prior to the first dose administration ; who receive any drug known to affect renal tubular secretion like probenecid, beta-lactam antibiotics within 2 weeks prior to the first dose administration ; who present any clinical condition or prior therapy which, in the opinion of the investigator, made the subject unsuitable for the study.