Bevacizumab and Radiation Therapy for Sarcomas

Inclusion Criteria: Primary soft tissue sarcoma (STS) or an isolated local recurrence of STS. Open incisional biopsy or core biopsies should be performed within 8 weeks prior to registration Tumor grade of intermediate or high grade Tumor must be located on the upper extremity, the lower extremity, trunk, retroperitoneum, or pelvis Primary tumors must be > 5.0cm in maximal diameter and local recurrence can be any size 18 years of age or older Zubrod performance status of 0-2 Adequate organ and marrow function Exclusion Criteria: Metastatic disease Pregnant or lactating women HIV positive patients Prior treatment with radiation, chemotherapy or biotherapy for this tumor History or evidence of central nervous system (CNS) disease Serious, non-healing wound, ulcer, or bone fracture Clinically significant cardiovascular disease, New York Heart Association (NYHA) Grade II or greater congestive heart failure, serious cardiac arrhythmia requiring medication, or Grade II or greater peripheral vascular disease within 1 year History of stroke within the past 6 months Major surgical procedure or significant traumatic injury within 28 days Current or recent (within 10 days) use of full-dose oral or parenteral anticoagulants or thrombolytic agents. Presence of bleeding diathesis or coagulopathy Proteinuria at baseline or clinically significant impairment of renal function History of abdominal fistula, gastrointestinal perforation, or inta-abdominal abscess within the past 6 months Documented history of uncontrolled seizures Grade 2 or greater sensory neuropathy based upon the NCI CTCAE, version 3.0 Known history of deep vein thrombosis or pulmonary embolus Known hypercoagulable disorder History of hepatic cirrhosis or current hepatic dysfunction