Azithromycin Level in Tears and in Conjunctiva in 36 Healthy Volunteers

Inclusion Criteria: Written informed consent; Healthy volunteers; Registered in the national register of healthy volunteers; Male or female aged from 18 to 45 years old; Able to understand the study instructions; Likely to comply with the study schedule and treatment; Normal subjective ocular symptoms, Schirmer test > 10 mm in 5 min and corrected visual acuity >= 6/10 in both eyes Exclusion Criteria: Ocular trauma, infection or inflammation within the last 3 months; Blepharitis; Conjunctival hyperaemia (score >= 2); Fluorescein-stained punctuations (score >= 1b); Hypersensitivity to one of the products used in the study; Clinically relevant allergy; Medical or surgical history incompatible with the study; Recent acute illness; Ocular surgery, including LASIK, LASEK and PRK within the last 12 months; Other ocular lasers or Zithromax® or Azadose® within the last 3 months; Systemic antibiotics and ocular medications within the last month; Contact lenses within the last week; Any medication on Day 0 and during the study (except paracetamol and contraceptives).