Weaning From Mechanical Ventilation Using Permissive Hypercarbia
Respiration, Artificial, Respiratory Distress Syndrome, Adult
About this trial
This is an interventional treatment trial for Respiration, Artificial focused on measuring permissive hypercarbia, weaning from mechanical ventilation
Eligibility Criteria
Inclusion Criteria: Adult (> 18 yo) patients in the intensive care units at the Hershey Medical Center who are on mechanical ventilation and whose clinical course permits weaning from mechanical ventilation and are felt to have risk factors for difficult weaning. (Risk factors will include patients with rib fractures, pulmonary contusions, obesity (BMI >30), or history of COPD or other significant lung disease.) all patients will have failed (rapid shallow breathing index >105) a 30 minute spontaneous breathing test. Exclusion Criteria: Overt signs of sepsis including: a temperature > 38.5F, white blood cell count > 14000, systolic blood pressure < 100 mmHg, intracranial hypertension (ICP > 18 or based upon clinical exam and/or history), or pulmonary hypertension (by history or PAsys > 40 mmHg). or history of recent(past 6 mos)MI
Sites / Locations
- Penn State Milton S. Hershey Medical Center