Sequestration of Platelets Prior to Bypass Reduces Bleeding After Cardiac Surgery
Cardiac Surgical Procedures, Cardiopulmonary Bypass, Blood Platelet Disorders
About this trial
This is an interventional treatment trial for Cardiac Surgical Procedures focused on measuring Cardiopulmonary bypass, Blood component removal
Eligibility Criteria
Inclusion Criteria: Adult patients undergoing cardiac surgery that involves: Repeat median sternotomy Mitral valve repair Double valve operations Combined valve and coronary surgery Anticipated prolonged cardiopulmonary bypass Exclusion Criteria: Pre-operative anaemia Pre-operative thrombocytopenia Unstable angina Anti-platelet therapy (e.g. aspirin, clopidogrel) within the previous 7 days Known or symptomatic cerebrovascular disease Known disorders of haemostasis Aprotinin sensitivity Pregnancy.
Sites / Locations
- Royal Brompton Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Platelet sequestration
Standard care
Sequestration of platelet rich plasma before cardiopulmonary bypass
No platelet rich plasma sequestration undertaken before cardiopulmonary bypass (usual practice)