Genetic Studies of X-linked Lymphoproliferative Disease
X-Linked Lymphoproliferative Disease, Lymphoproliferative Disease, Genetic Diseases, X-Linked
About this trial
This is an observational trial for X-Linked Lymphoproliferative Disease focused on measuring Epstein-Barr Virus, B-Cell Lymphoma, Herpes Virus, Infectious Mononucleosis
Eligibility Criteria
INCLUSION CRITERIA: Patients known to have XLPD and their relatives will be recruited from families who have enrolled in a national XLPD registry. All racial and ethnic groups will be considered. To be considered having XLPD, a patient must be a male who has had: severe infectious mononucleosis, or acquired hypogammaglobulinemia following infectious mononucleosis, or nonHodgkin's lymphoma, or hyper-IgM or an IgG subclass deficiency with evidence of linkage to the DXS42 locus and have no other known immunocompromising condition and belong to a family in which another related male has had one or more of the above listed phenotypes. EXCLUSION CRITERIA: Known HIV infection in any patient with XLPD or their relative (blood will not be tested for HIV), complicating medical or psychiatric conditions in unrelated controls.
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike