Elucidation of Acid-Induced Pulmonary Inflammation
Gastroesophageal Reflux, Asthma
About this trial
This is an interventional treatment trial for Gastroesophageal Reflux
Eligibility Criteria
Inclusion Criteria: chronic cough consistent with bronchoreactivity Gastroesophageal reflux Exclusion Criteria: Severe asthmatics who have been hospitalized within the last 6 months or who have required oral steroid use within the last 4 weeks Severe coronary artery disease Cigarette/cigar smoking within the last 6 months Documented allergies affecting the respiratory system Subjects with contraindications to pH/impedance probe Hemophilia Septal deviation Subjects with contraindications to bronchoscopy as outlined by the American Thoracic Society Guidelines Anticoagulation Pregnancy Incarcerated patients Current oral steroid use (may suppress levels of inflammation) Upper respiratory infection within the last 2 weeks Ongoing acid suppression with a proton pump inhibitor, however, patients may be included if they have discontinued their proton pump inhibitor within the last 1 month with stable asthma symptoms as defined by stable utilization of inhaled steroids
Sites / Locations
- University of Utah Health Sciences Center
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Lansoprazole therapy
Placebo
Lansoprazole 30 mg orally twice daily
placebo orally twice daily