Topiramate on Gambling-Related Behaviours
Gambling
About this trial
This is an interventional treatment trial for Gambling focused on measuring problem gambling, topiramate
Eligibility Criteria
Inclusion Criteria: 19 - 65 years of age either gender plays electronic gaming machines (e.g. slot machine, video poker) meets DSM IV criteria for pathological gambling Exclusion Criteria: females pregnant or breastfeeding at study entry females of childbearing age and physically able to conceive but not on oral contraceptives or patch, unwilling to take pregnancy self-test before each test session females taking oral contraceptives or patch but unwilling to use a barrier method of contraceptive during the course of the study occupation involving driving or operating heavy machinery BMI < 20 hepatic dysfunction or hepatitis, as indicated by elevated INR, low serum albumin, or high bilirubin, or elevated AST, ALT, GGT (>1.5 times normal) clinical evidence of cirrhosis on examination renal insufficiency (creatinine >150) history of renal stones history of glaucoma current seizure disorder current use of digoxin current use of benzodiazepines alcohol consumption >14 drinks /week current use of anti-seizure medications (phenytoin, carbamazepine, valproic acid, primadone), antipsychotic medications (e.g., seroquel), carbonic anhydrase inhibitors (acetazolamide), metformin diagnosis of Axis I disorders, including psychoactive substances disorders (except nicotine)
Sites / Locations
- Centre for Addiction and Mental Health