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A Study of Erlotinib (Tarceva) After Surgery With or Without Adjuvant Chemotherapy in Non-Small Cell Lung Carcinoma (NSCLC) Patients Who Have Epidermal Growth Factor Receptor (EGFR) Positive Tumors (RADIANT)

Primary Purpose

Non-small Cell Lung Cancer

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Erlotinib
Placebo
Sponsored by
OSI Pharmaceuticals
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Non-small Cell Lung Cancer focused on measuring Adjuvant Non-small Cell Lung Cancer, Tarceva, Early-stage Lung Cancer, Adjuvant, RADIANT, NSCLC, EGFR-positive tumor, Stage IB Non-small Cell Lung Cancer, Stage II Non-small Cell Lung Cancer, Stage IIIA Non-small Cell Lung Cancer

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Primary tissue from patient's surgery must be epidermal growth factor receptor (EGFR)-positive by certain tests
  • Patients may have up to 4 cycles of chemotherapy after surgery
  • Complete removal of the tumor by surgery

  • Able to start drug under the following timelines:

    • 6 months from the day of surgery for patients who get chemotherapy
    • 3 months from the day of surgery for those who do not get chemotherapy
  • Confirmed diagnosis of Stage IB-IIIA NSCLC
  • Patients must be accessible for follow-up visits

Exclusion Criteria:

  • History of prior radiotherapy for NSCLC either before or after surgery
  • History of heart disease or uncontrolled heart arrhythmias within the previous year
  • History of poorly controlled gastrointestinal (GI) disorders that could affect the absorption of study drug
  • History of other cancer except certain skin or cervical cancers, patients who have had other cancer are eligible if they have remained disease free for at least 5 years
  • Patients who have received chemotherapy for NSCLC before surgery
  • Tumors with mixed histology of NSCLC and Small Cell Lung Cancer (SCLC). Patients with carcinoid tumors are not eligible.

Sites / Locations

  • University of Alabama at Birmingham
  • Arizona Cancer Center
  • University of Arkansas for Medical Science
  • Tower Cancer Research Foundation
  • City of Hope Nat'l Medical Center
  • Loma Linda University Medical Center
  • USC/ Norris Comprehensive Cancer Center
  • Cedars-Sinai Medical Center
  • Hoag Memorial Hospital Presbyterian
  • Comprehensive Cancer Center at Desert Regional Medical Center
  • Bay Area Cancer Research Group, LLC
  • University of California, San Francisco Comprehensive Cancer Center
  • City of Hope Medical Group (COHMG)
  • Rocky Mountain Cancer Center- Aurora
  • University of Colorado Hospital
  • Rocky Mountain Cancer Centers-Boulder
  • Penrose St. Francis Health Services
  • Rocky Mountain Cancer Center
  • Rocky Mountain Cancer Center
  • Rocky Mountain Cancer Center-Midtown
  • Rocky Mountain Cancer Centers- Rose
  • Rocky Mountain Cancer Centers
  • Rocky Mountain Cancer Centers-Littleton
  • Rocky Mountain Cancer Center-Sky Ridge
  • Rocky Mountain Cancer Centers-Longmont
  • Rocky Mountain Cancer Center-Parker
  • Rocky Mountain Cancer Centers
  • Yale University
  • Smilow Cancer Hospital Care Center
  • Hematology Oncology, P.C.
  • Smilow Cancer Hospital Care Center
  • Florida Cancer Institute-New Hope
  • Cancer Specialists of North Florida
  • Cancer Specialists of North Florida
  • Watson Clinic LLP
  • Advanced Medical Specialties
  • Florida Cancer Institute- New Hope
  • Florida Cancer Specialists
  • Hematology Oncology Associates of the Treasure Coast
  • Peachtree Hematology-Oncology Consultants, P.C.
  • Central Georgia Cancer Care, PC
  • Northwest Georgia Oncology Centers, PC
  • Mountain States Tumor Institute
  • Mountain States Tumor Institute
  • Kootenai Cancer Center
  • Mountain States Tumor Institute
  • Rush University Medical Center
  • University of Chicago, Section of Hematology/Oncology
  • Joliet Oncology Hematology Assoc., LTD
  • Loyola University Medical Center
  • Indiana University Health
  • Indiana University Health
  • Indiana University Health
  • Indiana University Health
  • Indiana University Health
  • University of Kansas Medical Center
  • Norton Healthcare, Inc.
  • Leonard J. Chabert Medical Center
  • Cancer Care of Maine
  • Greater Baltimore Medical Center
  • St. Joseph Medical Center's Cancer Institute
  • Caritas St. Elizabeth's Medical Center
  • St. Joseph Mercy Hospital
  • Minnesota Oncology Hematology, P.A.
  • Minnesota Oncology Hematology, P.A.
  • Minnesota Oncology Hematology, P.A.
  • Minnesota Oncology Hematology, P.A.
  • Minnesota Oncology Hematology
  • Minnesota Oncology Hematology, P.A.
  • Missouri Cancer Associates
  • Heartland Regional Medical Center d/b/a Heartland Clinic
  • St. Francis Cancer Treatment Center
  • Nebraska Methodist Hospital
  • Comprehensive Cancer Centers of Nevada
  • Comprehensive Cancer Centers of Nevada
  • Comprehensive Cancer Centers of Nevada
  • Comprehensive Cancer Centers of Nevada
  • NH Oncology-Hematology PA (Co)
  • NH Oncology-Hematology PA
  • Dartmouth-Hitchcock Medical Center
  • Hackensack University Medical Center
  • University of New Mexico Health Science Center
  • Christus St. Vincent Regional Cancer Center
  • Interlakes Oncology Hematology, PC
  • Montefiore Medical Center
  • Interlakes Oncology Hematology, PC
  • Interlakes Oncology Hematology, PC
  • Advanced Oncology Associates
  • The New York Presbyterian-Weill Medical College of Cornell University
  • Interlakes Oncology Hematology, PC
  • Interlakes Oncology Hematology, PC
  • Stony Brook University Medical Center
  • Raleigh Hematology Oncology Associates d/b/a Cancer Center of North Carolina
  • Carolina Oncology Specialists PA
  • Raleigh Hematology Oncology Associates
  • Raleigh Hematology Oncology Associates
  • Aultman Hospital/ North Canton Medical Foundation
  • University Hopsitals of Cleveland
  • Hematology Oncology Consultants Inc.
  • Earle A Chiles Research Institute
  • Northwest Cancer Specialists, PC
  • Northwest Cancer Specialists, PC
  • Northwest Cancer Specialists, PC
  • Northwest Cancer Specialists, PC
  • Cancer Care Associates - Medical Oncology
  • The Hospital of the University of Pennsylvania
  • Allegheny General Hospital
  • South Carolina Oncology Assoc., PA
  • Cancer Centers of the Carolinas
  • Cancer Centers of the Carolinas
  • Cancer Centers of the Carolinas
  • Cancer Centers of the Carolinas, Seneca
  • Cancer Centers of the Carolinas
  • Cookeville Regional Medical Center
  • Bostin Baskin Cancer Foundation
  • Tennessee Cancer Specialists
  • Bostin Baskin Cancer Foundation
  • Family Cancer Center Foundation, Inc.
  • West Clinic
  • Sarah Cannon Cancer Center
  • Sarah Cannon Research Institute
  • Texas Oncology, P.A. - Amarillo
  • Texas Oncology Beaumont
  • Texas Oncology Texas Cancer Center at Medical City
  • Baylor Charles A Sammons Cancer Center
  • Texas Oncology - Flower Mound
  • Texas Oncology Southwest Forth Worth
  • Texas Oncology, Fort Worth
  • Texas Oncology, Garland
  • Cancer Care Centers of South Texas - HOAST
  • Texas Oncology - Paris
  • Texas Oncology - Plano East
  • Cancer Care Centers of South Texas-HOAST
  • Texas Oncology -Tyler
  • Texas Oncology Cancer Care and Research Center
  • Onc and Hem Associates of SW VA, Inc. d/b/a Blue Ridge Cancer Care
  • Onc and Hem Associates of SW VA, Inc.
  • Virginia Oncology Associates
  • Virginia Oncology Associates
  • Virginia Oncology Associates
  • Onc and Hem Associates of SW VA, Inc. d/b/a Blue Ridge Cancer Care
  • Onc and Hem Assoc of SW VA, Inc d/b/a Blue Ridge Cancer Care
  • Onc and Hem Associates of SW VA, Inc. d/b/a Blue Ridge Cancer Care
  • Univ. of Washington/ Seattle Cancer Care Alliance
  • Cancer Care Northwest-Valley
  • Cancer Care Northwest
  • Cancer Care Northwest-North
  • Northwest Cancer Specialists, P.C.
  • Northwest Cancer Specialist, P.C.
  • Hospital Italiano de Buenos Aires
  • Hospital de Rehabilitación Respiratoria María Ferrer
  • COIR
  • Hospital Espanol de Rosario
  • ISIS Centro Especializado De Luce S.A.
  • Campbelltown Hospital
  • Liverpool Hospital
  • Royal North Shore Hospital
  • Monash Medical Centre
  • St Vincent's Hospital Melbourne
  • Austin Hospital
  • Respiratory Clinical Trials Pty., Ltd
  • Ashford Cancer Centre
  • Universitaetsklinikum Innsbruck
  • Allgemeines Krankenhaus der Stadt Linz
  • Landeskrankenhaus SalzburgUniversitaetsklinikum der PMUUniversitaetsklinik für Pneumologie
  • AKH Wien
  • Krankenhaus Hietzing
  • SMZ Baumgartner Hoehe - Otto Wagner Spital
  • SMZ Baumgartner Höhe - Otto- Wagner-Spital
  • Hôpital Erasme
  • Cliniques Universitaires Saint-Luc
  • Le Grand Hôpital de Charleroi
  • Centre Hospitalier Jolimont-Lobbes
  • Cross Cancer Institute
  • Cancer Center of Southeastern Ontario at Kingston General Hospital
  • Trillium Health Partners - Credit Valley Hospital
  • Stronach Regional cancer Centre at Southlake
  • RS MacLaughlin Durham Regional Cancer Centre
  • Sault Area Hospital
  • Thunder Bay Regional Health Science Centre
  • Toronto General Hospital
  • McGill Dept. of Oncology
  • Royal Victoria Hospital
  • Montreal General Hospital
  • St. Joseph's Health Centre
  • Nemocnice Ceske Budejovice, a.s.
  • Fakultni nemocnice OstravaKlinika tuberkulozy a respiracnich nemoci
  • FN Bulovka Klinika plincni a hrrudni chirurgie
  • CHU Larrey Service de Pneumologie, Clinique des voies respiratoires
  • Centre d'Oncologie et de Radiothérapie du Pays Basque
  • C.H.U. Morvan, Institut de Cancerologie et d'Hématologie
  • CHU de Caen - Service de pneumologie
  • CHU Clermont Ferrand - Hôpital Gabriel Montpied - Service de pneumologie
  • Hopital De La Croix-Rousse Service de Pneumologie
  • Institut Paoli-Calmettes
  • Fondation Hôpital Saint Joseph
  • Hôpital de Tenon
  • Centre Catalan d'Oncologie
  • CHU - Hopital Pontchaillou - Service de pneumologie
  • Institut de Cancérologie de la Loire
  • Hôpital de Brabois
  • Zentralklinik Bad Berka
  • HELIOS Klinikum Emil von Behring GmbH
  • Augusta-Krankenanstalt Bochum
  • Fachkrankenhaus Coswig
  • Universitaetsklinikum Essen
  • Krankenhaus Nordwest
  • Universitätsklinikum Freiburg
  • Lungenclinic Großhansdorf
  • Universitätsklinikum Göttingen
  • Städtisches Krankenhaus Martha-Maria, Halle-Dölau
  • Asklepios Klinik Harburg
  • Thoraxklinik Heidelberg
  • Lungenklink Hemer des Deutschen Gemeinschafts-Diakonieverbandes GmbH
  • St. Vincentius-Kliniken Karlsruhe
  • Universitaetsklinikum Schleswig-Holstein
  • Universitätsklinikum Mainz
  • Asklepios Klinikum Gauting
  • Pius Hospital Oldenburg
  • Schwarzwald-Baar Klinikum
  • IASO GENERAL Hospital of Athens
  • "Papageorgiou" General Hospital of Thessaloniki
  • "G. Papanikolaou" General Hospital of Thessaloniki
  • Országos Korányi TBC és Pulmonológiai Intézet
  • Semmelweis Egyetem Altalanos Orvostudomanyi Kar Pulmonologiai Klinika
  • Csongrad Megyei Onkormanyzat, Mellkasi Betegsegek Szakkorhaza
  • Pecsi Tudomany Egyete m Klinikai Kozpont, I.sz Belgyogyaszati Klinika Pulmonologiai Munkacsoport
  • Fejer Megyei Szent Gyorgy Korhaz
  • Vas Megyei Markusovszky Lajos Altalanos Rehabilitacios es Gyogyfurdo Korhaz, Egyetemi Oktatoko Zarkoruen Mukodo Nonprofit Reszveny Tarsasag
  • Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I
  • Ospedale Bellaria
  • Ospedale Garibaldi Nesima
  • Istituto Nazionale per la Ricerca e la Cura del Cancro
  • Azienda Ospedaliero- Universitaria di Parma
  • Ospedale S. Maria della Misericordia
  • Azienda Ospedaliera San Camillo Forlanini
  • Saint Vincent's Hospital
  • Gachon Medical School Ghil Medical Center
  • Seoul National University Hospital
  • Severance Hospital, Yonsei Univ. College of Medicine
  • Asan Medical Center
  • Samodzielny Publiczny Szpital Kliniczny Nr 4
  • Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy
  • Wielkoposkie Centrum Pulmonologii i Torakochirurgii, Oddzial Onkologii Klinicznej z Pododdzialem Dziennej Chemioterapii
  • Specjalistyczny Szpital im. prof.Alfreda Sokolowskiego
  • Centrum Onkologii - Instytut im. Marii Skllodowskiej - Curie
  • Dolnoslaskie Centrum Chorob Pluc we Wroclawiu, Katedra i Klinika Pulmonologii i Nowotworow Pluc Akademii Medycznej
  • Spitalui Clinic Judetean de Urgenta, Sectia de Oncologie
  • Oncoloab SRL
  • Institutul Oncologic Al. Trestioreanu Sectia Oncologie Medicala II
  • Institutul Oncologic Al. Trestioreanu
  • Institutul Oncologic Prof. Dr. Ion Chiricuta
  • Centrul de Oncologie Medicala
  • Spitalul Clinic Judetean Sibiu
  • State Healthcare Institution "Arkhangelsk Regional Clinical Oncology Dispensary"
  • State Healthcare Institution "Regional Clinical Oncology Dispensary"
  • State Healthcare Institution "Region Clinical Hospital # 1 n.a. professor S.V. Ochapovsky"
  • State Institution "Central Military Clinical Hospital n.a. academician N.N. Burdenko under the Ministry of Defense of Russia"
  • Institution of the RAMS "Russian Oncology Scientific Centre n.a. N.N. Blokhin under the Russian Academy of Medical Sciences"
  • State Educational Institution of Higher Professional Education "Saint-Petersburg State Medical University n.a. ac. I.P. Pavlov of the Ministry of Healthcare and Social Development of the Russian Federation"
  • Federal State Institution "Petrov Scientific Research Institute of Oncology of Rosmedtechnology"
  • Saint-Petersburg State Healthcare Institution "City Clinical Oncology Dispensary"
  • Regional State Budget Healthcare Instiution"Tomsk Regional Oncology Dispensary"
  • State Healthcare Institution of Yaroslavl Region "Regional Clinical Oncology Hospital"
  • ICO (Institut Catalá d´Oncología)
  • Fundació Althaia
  • Corporació Sanitaria Parc Taulí
  • Hospital Puerta de Hierro Majadahonda
  • Hospital Oncologico MD Anderson
  • Hospital Universitario 12 de Octubre
  • Hospital Universitario La Paz
  • Hospital Carlos Haya
  • Hospital Clínico Virgen de la Victoria
  • Clinica Universitaria de Navarra
  • Hospital Universitario Marques de Valdecilla
  • Hospital Universitario de Valme
  • Hospital Virgen de la Salud de Toledo
  • Hospital General Universitario de Valencia
  • Changhua Christian Hospital
  • Chang Gung Medical Foundation
  • Chung Shan Medical University Hospital
  • China Medical University Hospital
  • Taichung Veterans General Hospital
  • Taipei Veterans General Hospital
  • Chang Gung Memorial Hospital
  • Birmingham Heartlands Hospital
  • Bristol Haematology and Oncology Centre
  • Ninewells Hospital
  • Beatson West of Scotland Cancer Centre
  • The Royal Surrey County Hospital NHS Trust
  • Leicester Royal Infirmary
  • St James' Institute of Oncology, Bexley Wing, St James' University Hospital
  • Guy's Hospital
  • Royal Marsden Hospital
  • Royal Marsden Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Erlotinib

Placebo

Arm Description

Participants received 150 mg/day erlotinib orally for 2 years or until relapse, death, participant request or investigator decision to discontinue study drug, or intolerable toxicity.

Participants received matching placebo tablets orally for 2 years or until relapse, death, participant request or investigator decision to discontinue study drug, or intolerable toxicity.

Outcomes

Primary Outcome Measures

Disease Free Survival (DFS)
DFS is the time from the date of randomization until the first day non-small cell lung cancer (NSCLC) relapse is documented by radiological exam and/or biopsy, or until death in the absence of relapse. After randomization, NSCLC relapse was based on radiological evidence or biopsy, as determined by the investigator. Participants without a DFS event were censored on the last adequate radiological assessment date.
Disease Free Survival (DFS)
DFS is the time from the date of randomization until the first day that non-small cell lung cancer (NSCLC) relapse is documented by radiological exam and/or biopsy, or until death in the absence of relapse. After randomization, NSCLC relapse was based on radiological evidence or biopsy, as determined by the investigator. Participants without a DFS event were censored on the last adequate radiological assessment date.

Secondary Outcome Measures

Overall Survival (OS)
Overall survival was defined as the time from the date of randomization until the documented date of death. Participants who were still alive were censored on the last day they were known to be alive.
Overall Survival (OS)
Overall survival was defined as the time from the date of randomization until the documented date of death. Participants who were still alive were censored on the last day they were known to be alive.
Disease-free Survival in Participants With EGFR Mutation - Positive Tumors
Disease-free survival (DFS) is the time from the date of randomization until the first day NSCLC relapse is documented by radiological exam and/or biopsy, or until death in the absence of relapse. After randomization, NSCLC relapse was based on radiological evidence or biopsy, as determined by the investigator. Participants without a DFS event were censored on the last adequate radiological assessment date. Activating EGFR mutation-positive is defined as exon 19 deletion or exon 21 L858R (or both) detected.
Disease-free Survival in Participants With EGFR Mutation - Positive Tumors
Disease-free survival (DFS) is the time from the date of randomization until the first day NSCLC relapse is documented by radiological exam and/or biopsy, or until death in the absence of relapse. After randomization, NSCLC relapse was based on radiological evidence or biopsy, as determined by the investigator. Participants without a DFS event were censored on the last adequate radiological assessment date. Activating EGFR mutation-positive is defined as exon 19 deletion or exon 21 L858R (or both) detected.
Overall Survival in Participants With EGFR Mutation - Positive Tumors
Overall survival is defined as the time from the date of randomization until the documented date of death. Participants who were still alive were censored on the last day they were known to be alive. Activating EGFR mutation-positive is defined as exon 19 deletion or exon 21 L858R (or both) detected.
Overall Survival in Participants With EGFR Mutation - Positive Tumors
Overall survival is defined as the time from the date of randomization until the documented date of death. Participants who were still alive were censored on the last day they were known to be alive. Activating EGFR mutation-positive is defined as exon 19 deletion or exon 21 L858R (or both) detected.
Number of Participants With Adverse Events (AEs)
An AE was defined as any untoward medical occurrence in a study participant and did not necessarily have a causal relationship with study treatment. An AE was considered serious if it resulted in death, a life-threatening situation, inpatient hospitalization or prolongation of existing hospitalization, persistent or significant disability/incapacity, congenital anomaly/birth defect in the offspring of a participant, other important medical events, or is on the Astellas Always Serious List. A drug-related AE was any AE with at least a possible relationship to study treatment as assessed by the investigator. Severity was graded by the investigator according to the National Cancer Institute Common Terminology Criteria for Adverse Events, v3.0, where Grade 1=Mild AE; Grade=2 Moderate AE; Grade 3=Severe AE; Grade 4=Life-threatening or disabling; Grade 5=Death related to AE. AEs leading to death include deaths that occurred more than 30 days after the last dose of study drug.

Full Information

First Posted
September 7, 2006
Last Updated
September 1, 2015
Sponsor
OSI Pharmaceuticals
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1. Study Identification

Unique Protocol Identification Number
NCT00373425
Brief Title
A Study of Erlotinib (Tarceva) After Surgery With or Without Adjuvant Chemotherapy in Non-Small Cell Lung Carcinoma (NSCLC) Patients Who Have Epidermal Growth Factor Receptor (EGFR) Positive Tumors
Acronym
RADIANT
Official Title
A Multi-center, Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Single-agent Tarceva® (Erlotinib) Following Complete Tumor Resection With or Without Adjuvant Chemotherapy in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma Who Have EGFR-positive Tumors
Study Type
Interventional

2. Study Status

Record Verification Date
September 2015
Overall Recruitment Status
Completed
Study Start Date
September 2006 (undefined)
Primary Completion Date
April 2013 (Actual)
Study Completion Date
June 2014 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
OSI Pharmaceuticals

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This is a study to evaluate the effectiveness of erlotinib compared with a placebo sugar pill following complete surgical removal of the tumor with or without chemotherapy after surgery in Stage IB-IIIA NSCLC patients.
Detailed Description
After the initiation of the study, the sponsor became aware of an error in the drug dispensing module of the interactive voice response such that most patients who were randomized prior to 07 November 2007 were dispensed the incorrect study drug at least once. Since the integrity of the data from these patients was seriously compromised, these patients were considered unevaluable for the protocol-specified analyses. These participants are referred to as the breached protocol cohort (BPC) and those still on study treatment at the time of the breach were offered the option of receiving open-label erlotinib for up to 2 years (including posttreatment and long-term follow-up assessments), not receiving open-label erlotinib but remaining in the study for posttreatment and long-term follow-up assessment, or withdrawing consent from treatment and further assessments. Participants who had discontinued study treatment prior to the breach were not offered open-label erlotinib and remained in long-term follow-up. Data from the BPC participants were analyzed separately and were not included in the assessments of primary or secondary endpoints in the randomized cohort and were not considered part of the primary analyses.The sample size for the randomized cohort was not changed due to the BPC and the data from RC and BPC were analyzed separately.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Non-small Cell Lung Cancer
Keywords
Adjuvant Non-small Cell Lung Cancer, Tarceva, Early-stage Lung Cancer, Adjuvant, RADIANT, NSCLC, EGFR-positive tumor, Stage IB Non-small Cell Lung Cancer, Stage II Non-small Cell Lung Cancer, Stage IIIA Non-small Cell Lung Cancer

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
1252 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Erlotinib
Arm Type
Experimental
Arm Description
Participants received 150 mg/day erlotinib orally for 2 years or until relapse, death, participant request or investigator decision to discontinue study drug, or intolerable toxicity.
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Participants received matching placebo tablets orally for 2 years or until relapse, death, participant request or investigator decision to discontinue study drug, or intolerable toxicity.
Intervention Type
Drug
Intervention Name(s)
Erlotinib
Other Intervention Name(s)
OSI-774, Tarceva
Intervention Description
150 mg tablet
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Placebo tablet
Primary Outcome Measure Information:
Title
Disease Free Survival (DFS)
Description
DFS is the time from the date of randomization until the first day non-small cell lung cancer (NSCLC) relapse is documented by radiological exam and/or biopsy, or until death in the absence of relapse. After randomization, NSCLC relapse was based on radiological evidence or biopsy, as determined by the investigator. Participants without a DFS event were censored on the last adequate radiological assessment date.
Time Frame
Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cut-off date of 08 April 2013 (maximum time on follow-up was 64 months).
Title
Disease Free Survival (DFS)
Description
DFS is the time from the date of randomization until the first day that non-small cell lung cancer (NSCLC) relapse is documented by radiological exam and/or biopsy, or until death in the absence of relapse. After randomization, NSCLC relapse was based on radiological evidence or biopsy, as determined by the investigator. Participants without a DFS event were censored on the last adequate radiological assessment date.
Time Frame
Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cutoff date of 11 June 2014 (maximum time on follow-up was 78 months).
Secondary Outcome Measure Information:
Title
Overall Survival (OS)
Description
Overall survival was defined as the time from the date of randomization until the documented date of death. Participants who were still alive were censored on the last day they were known to be alive.
Time Frame
Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cut-off date of 08 April 2013 (maximum time on follow-up was 64 months).
Title
Overall Survival (OS)
Description
Overall survival was defined as the time from the date of randomization until the documented date of death. Participants who were still alive were censored on the last day they were known to be alive.
Time Frame
Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cut-off date of 11 June 2014 (maximum time on follow-up was 78 months).
Title
Disease-free Survival in Participants With EGFR Mutation - Positive Tumors
Description
Disease-free survival (DFS) is the time from the date of randomization until the first day NSCLC relapse is documented by radiological exam and/or biopsy, or until death in the absence of relapse. After randomization, NSCLC relapse was based on radiological evidence or biopsy, as determined by the investigator. Participants without a DFS event were censored on the last adequate radiological assessment date. Activating EGFR mutation-positive is defined as exon 19 deletion or exon 21 L858R (or both) detected.
Time Frame
Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cut-off date of 08 April 2013 (maximum time on follow-up was 64 months).
Title
Disease-free Survival in Participants With EGFR Mutation - Positive Tumors
Description
Disease-free survival (DFS) is the time from the date of randomization until the first day NSCLC relapse is documented by radiological exam and/or biopsy, or until death in the absence of relapse. After randomization, NSCLC relapse was based on radiological evidence or biopsy, as determined by the investigator. Participants without a DFS event were censored on the last adequate radiological assessment date. Activating EGFR mutation-positive is defined as exon 19 deletion or exon 21 L858R (or both) detected.
Time Frame
Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cut-off date of 11 June 2014 (maximum time on follow-up was 78 months).
Title
Overall Survival in Participants With EGFR Mutation - Positive Tumors
Description
Overall survival is defined as the time from the date of randomization until the documented date of death. Participants who were still alive were censored on the last day they were known to be alive. Activating EGFR mutation-positive is defined as exon 19 deletion or exon 21 L858R (or both) detected.
Time Frame
Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cut-off date of 08 April 2013 (maximum time on follow-up was 64 months)
Title
Overall Survival in Participants With EGFR Mutation - Positive Tumors
Description
Overall survival is defined as the time from the date of randomization until the documented date of death. Participants who were still alive were censored on the last day they were known to be alive. Activating EGFR mutation-positive is defined as exon 19 deletion or exon 21 L858R (or both) detected.
Time Frame
Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cut-off date of 11 June 2014 (maximum time on follow-up was 78 months)
Title
Number of Participants With Adverse Events (AEs)
Description
An AE was defined as any untoward medical occurrence in a study participant and did not necessarily have a causal relationship with study treatment. An AE was considered serious if it resulted in death, a life-threatening situation, inpatient hospitalization or prolongation of existing hospitalization, persistent or significant disability/incapacity, congenital anomaly/birth defect in the offspring of a participant, other important medical events, or is on the Astellas Always Serious List. A drug-related AE was any AE with at least a possible relationship to study treatment as assessed by the investigator. Severity was graded by the investigator according to the National Cancer Institute Common Terminology Criteria for Adverse Events, v3.0, where Grade 1=Mild AE; Grade=2 Moderate AE; Grade 3=Severe AE; Grade 4=Life-threatening or disabling; Grade 5=Death related to AE. AEs leading to death include deaths that occurred more than 30 days after the last dose of study drug.
Time Frame
From the date of first dose of study drug until 30 days after the last dose. The median time on treatment was 11.9 months for erlotinib and 21.9 months for placebo. Data are based off the 11 June 2014 data cut-off date.

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Primary tissue from patient's surgery must be epidermal growth factor receptor (EGFR)-positive by certain tests Patients may have up to 4 cycles of chemotherapy after surgery Complete removal of the tumor by surgery Able to start drug under the following timelines: 6 months from the day of surgery for patients who get chemotherapy 3 months from the day of surgery for those who do not get chemotherapy Confirmed diagnosis of Stage IB-IIIA NSCLC Patients must be accessible for follow-up visits Exclusion Criteria: History of prior radiotherapy for NSCLC either before or after surgery History of heart disease or uncontrolled heart arrhythmias within the previous year History of poorly controlled gastrointestinal (GI) disorders that could affect the absorption of study drug History of other cancer except certain skin or cervical cancers, patients who have had other cancer are eligible if they have remained disease free for at least 5 years Patients who have received chemotherapy for NSCLC before surgery Tumors with mixed histology of NSCLC and Small Cell Lung Cancer (SCLC). Patients with carcinoid tumors are not eligible.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Medical Monitor
Organizational Affiliation
Astellas Pharma Global Development
Official's Role
Study Director
Facility Information:
Facility Name
University of Alabama at Birmingham
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
Facility Name
Arizona Cancer Center
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85724
Country
United States
Facility Name
University of Arkansas for Medical Science
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
Tower Cancer Research Foundation
City
Beverly Hills
State/Province
California
ZIP/Postal Code
90211
Country
United States
Facility Name
City of Hope Nat'l Medical Center
City
Duarte
State/Province
California
ZIP/Postal Code
91010
Country
United States
Facility Name
Loma Linda University Medical Center
City
Loma Linda
State/Province
California
ZIP/Postal Code
92354
Country
United States
Facility Name
USC/ Norris Comprehensive Cancer Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Cedars-Sinai Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Hoag Memorial Hospital Presbyterian
City
Newport Beach
State/Province
California
ZIP/Postal Code
92658
Country
United States
Facility Name
Comprehensive Cancer Center at Desert Regional Medical Center
City
Palm Springs
State/Province
California
ZIP/Postal Code
92262
Country
United States
Facility Name
Bay Area Cancer Research Group, LLC
City
Pleasant Hill
State/Province
California
ZIP/Postal Code
94523
Country
United States
Facility Name
University of California, San Francisco Comprehensive Cancer Center
City
San Francisco
State/Province
California
ZIP/Postal Code
94143-1770
Country
United States
Facility Name
City of Hope Medical Group (COHMG)
City
South Pasadena
State/Province
California
ZIP/Postal Code
91030
Country
United States
Facility Name
Rocky Mountain Cancer Center- Aurora
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80012
Country
United States
Facility Name
University of Colorado Hospital
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
Rocky Mountain Cancer Centers-Boulder
City
Boulder
State/Province
Colorado
ZIP/Postal Code
80303
Country
United States
Facility Name
Penrose St. Francis Health Services
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80907
Country
United States
Facility Name
Rocky Mountain Cancer Center
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80907
Country
United States
Facility Name
Rocky Mountain Cancer Center
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80909
Country
United States
Facility Name
Rocky Mountain Cancer Center-Midtown
City
Denver
State/Province
Colorado
ZIP/Postal Code
80218
Country
United States
Facility Name
Rocky Mountain Cancer Centers- Rose
City
Denver
State/Province
Colorado
ZIP/Postal Code
80220
Country
United States
Facility Name
Rocky Mountain Cancer Centers
City
Lakewood
State/Province
Colorado
ZIP/Postal Code
80228
Country
United States
Facility Name
Rocky Mountain Cancer Centers-Littleton
City
Littleton
State/Province
Colorado
ZIP/Postal Code
80120-4413
Country
United States
Facility Name
Rocky Mountain Cancer Center-Sky Ridge
City
Lone Tree
State/Province
Colorado
ZIP/Postal Code
80124
Country
United States
Facility Name
Rocky Mountain Cancer Centers-Longmont
City
Longmont
State/Province
Colorado
ZIP/Postal Code
80501
Country
United States
Facility Name
Rocky Mountain Cancer Center-Parker
City
Parker
State/Province
Colorado
ZIP/Postal Code
80138
Country
United States
Facility Name
Rocky Mountain Cancer Centers
City
Thornton
State/Province
Colorado
ZIP/Postal Code
80260
Country
United States
Facility Name
Yale University
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06520
Country
United States
Facility Name
Smilow Cancer Hospital Care Center
City
Sharon
State/Province
Connecticut
ZIP/Postal Code
06069
Country
United States
Facility Name
Hematology Oncology, P.C.
City
Stamford
State/Province
Connecticut
ZIP/Postal Code
06902
Country
United States
Facility Name
Smilow Cancer Hospital Care Center
City
Torrington
State/Province
Connecticut
ZIP/Postal Code
06790
Country
United States
Facility Name
Florida Cancer Institute-New Hope
City
Hudson
State/Province
Florida
ZIP/Postal Code
34667
Country
United States
Facility Name
Cancer Specialists of North Florida
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32204
Country
United States
Facility Name
Cancer Specialists of North Florida
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Watson Clinic LLP
City
Lakeland
State/Province
Florida
ZIP/Postal Code
33805
Country
United States
Facility Name
Advanced Medical Specialties
City
Miami
State/Province
Florida
ZIP/Postal Code
33176
Country
United States
Facility Name
Florida Cancer Institute- New Hope
City
New Port Richey
State/Province
Florida
ZIP/Postal Code
34655
Country
United States
Facility Name
Florida Cancer Specialists
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
Hematology Oncology Associates of the Treasure Coast
City
Port St. Lucie
State/Province
Florida
ZIP/Postal Code
34952
Country
United States
Facility Name
Peachtree Hematology-Oncology Consultants, P.C.
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30318
Country
United States
Facility Name
Central Georgia Cancer Care, PC
City
Macon
State/Province
Georgia
ZIP/Postal Code
31201
Country
United States
Facility Name
Northwest Georgia Oncology Centers, PC
City
Marietta
State/Province
Georgia
ZIP/Postal Code
30060
Country
United States
Facility Name
Mountain States Tumor Institute
City
Boise
State/Province
Idaho
ZIP/Postal Code
83712
Country
United States
Facility Name
Mountain States Tumor Institute
City
Meridian
State/Province
Idaho
ZIP/Postal Code
83642
Country
United States
Facility Name
Kootenai Cancer Center
City
Post Falls
State/Province
Idaho
ZIP/Postal Code
83854
Country
United States
Facility Name
Mountain States Tumor Institute
City
Twin Falls
State/Province
Idaho
ZIP/Postal Code
83301
Country
United States
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
University of Chicago, Section of Hematology/Oncology
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Facility Name
Joliet Oncology Hematology Assoc., LTD
City
Joliet
State/Province
Illinois
ZIP/Postal Code
60435
Country
United States
Facility Name
Loyola University Medical Center
City
Maywood
State/Province
Illinois
ZIP/Postal Code
60153
Country
United States
Facility Name
Indiana University Health
City
Carmel
State/Province
Indiana
ZIP/Postal Code
46032
Country
United States
Facility Name
Indiana University Health
City
Fishers
State/Province
Indiana
ZIP/Postal Code
46037
Country
United States
Facility Name
Indiana University Health
City
Greenfield
State/Province
Indiana
ZIP/Postal Code
46140
Country
United States
Facility Name
Indiana University Health
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46219
Country
United States
Facility Name
Indiana University Health
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46227
Country
United States
Facility Name
University of Kansas Medical Center
City
Westwood
State/Province
Kansas
ZIP/Postal Code
66205
Country
United States
Facility Name
Norton Healthcare, Inc.
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
Leonard J. Chabert Medical Center
City
Houma
State/Province
Louisiana
ZIP/Postal Code
70363
Country
United States
Facility Name
Cancer Care of Maine
City
Brewer
State/Province
Maine
ZIP/Postal Code
04412
Country
United States
Facility Name
Greater Baltimore Medical Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Facility Name
St. Joseph Medical Center's Cancer Institute
City
Towson
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Facility Name
Caritas St. Elizabeth's Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02135
Country
United States
Facility Name
St. Joseph Mercy Hospital
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48106
Country
United States
Facility Name
Minnesota Oncology Hematology, P.A.
City
Burnsville
State/Province
Minnesota
ZIP/Postal Code
55337
Country
United States
Facility Name
Minnesota Oncology Hematology, P.A.
City
Edina
State/Province
Minnesota
ZIP/Postal Code
55435-2150
Country
United States
Facility Name
Minnesota Oncology Hematology, P.A.
City
Maplewood
State/Province
Minnesota
ZIP/Postal Code
55109
Country
United States
Facility Name
Minnesota Oncology Hematology, P.A.
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55404
Country
United States
Facility Name
Minnesota Oncology Hematology
City
St. Paul
State/Province
Minnesota
ZIP/Postal Code
55102-2389
Country
United States
Facility Name
Minnesota Oncology Hematology, P.A.
City
Woodbury
State/Province
Minnesota
ZIP/Postal Code
55125
Country
United States
Facility Name
Missouri Cancer Associates
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65201
Country
United States
Facility Name
Heartland Regional Medical Center d/b/a Heartland Clinic
City
St. Joseph
State/Province
Missouri
ZIP/Postal Code
64507
Country
United States
Facility Name
St. Francis Cancer Treatment Center
City
Grand Island
State/Province
Nebraska
ZIP/Postal Code
68803
Country
United States
Facility Name
Nebraska Methodist Hospital
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68114
Country
United States
Facility Name
Comprehensive Cancer Centers of Nevada
City
Henderson
State/Province
Nevada
ZIP/Postal Code
89052
Country
United States
Facility Name
Comprehensive Cancer Centers of Nevada
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89128
Country
United States
Facility Name
Comprehensive Cancer Centers of Nevada
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89148
Country
United States
Facility Name
Comprehensive Cancer Centers of Nevada
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89169
Country
United States
Facility Name
NH Oncology-Hematology PA (Co)
City
Concord
State/Province
New Hampshire
ZIP/Postal Code
03301
Country
United States
Facility Name
NH Oncology-Hematology PA
City
Hooksett
State/Province
New Hampshire
ZIP/Postal Code
03106
Country
United States
Facility Name
Dartmouth-Hitchcock Medical Center
City
Lebanon
State/Province
New Hampshire
ZIP/Postal Code
03756
Country
United States
Facility Name
Hackensack University Medical Center
City
Hackensack
State/Province
New Jersey
ZIP/Postal Code
07601
Country
United States
Facility Name
University of New Mexico Health Science Center
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87131
Country
United States
Facility Name
Christus St. Vincent Regional Cancer Center
City
Santa Fe
State/Province
New Mexico
ZIP/Postal Code
87505
Country
United States
Facility Name
Interlakes Oncology Hematology, PC
City
Brockport
State/Province
New York
ZIP/Postal Code
14420
Country
United States
Facility Name
Montefiore Medical Center
City
Bronx
State/Province
New York
ZIP/Postal Code
10467
Country
United States
Facility Name
Interlakes Oncology Hematology, PC
City
Canadaigua
State/Province
New York
ZIP/Postal Code
14424
Country
United States
Facility Name
Interlakes Oncology Hematology, PC
City
Geneva
State/Province
New York
ZIP/Postal Code
14456
Country
United States
Facility Name
Advanced Oncology Associates
City
New Rochelle
State/Province
New York
ZIP/Postal Code
10801
Country
United States
Facility Name
The New York Presbyterian-Weill Medical College of Cornell University
City
New York
State/Province
New York
ZIP/Postal Code
10065
Country
United States
Facility Name
Interlakes Oncology Hematology, PC
City
Rochester
State/Province
New York
ZIP/Postal Code
14623
Country
United States
Facility Name
Interlakes Oncology Hematology, PC
City
Rochester
State/Province
New York
ZIP/Postal Code
14626
Country
United States
Facility Name
Stony Brook University Medical Center
City
Stony Brook
State/Province
New York
ZIP/Postal Code
11794
Country
United States
Facility Name
Raleigh Hematology Oncology Associates d/b/a Cancer Center of North Carolina
City
Cary
State/Province
North Carolina
ZIP/Postal Code
27511
Country
United States
Facility Name
Carolina Oncology Specialists PA
City
Hickory
State/Province
North Carolina
ZIP/Postal Code
28602
Country
United States
Facility Name
Raleigh Hematology Oncology Associates
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27607
Country
United States
Facility Name
Raleigh Hematology Oncology Associates
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27609
Country
United States
Facility Name
Aultman Hospital/ North Canton Medical Foundation
City
Canton
State/Province
Ohio
ZIP/Postal Code
44710
Country
United States
Facility Name
University Hopsitals of Cleveland
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
Hematology Oncology Consultants Inc.
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43228
Country
United States
Facility Name
Earle A Chiles Research Institute
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Facility Name
Northwest Cancer Specialists, PC
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Facility Name
Northwest Cancer Specialists, PC
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Facility Name
Northwest Cancer Specialists, PC
City
Portland
State/Province
Oregon
ZIP/Postal Code
97227
Country
United States
Facility Name
Northwest Cancer Specialists, PC
City
Tualatin
State/Province
Oregon
ZIP/Postal Code
97062
Country
United States
Facility Name
Cancer Care Associates - Medical Oncology
City
Bethlehem
State/Province
Pennsylvania
ZIP/Postal Code
18015
Country
United States
Facility Name
The Hospital of the University of Pennsylvania
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
Allegheny General Hospital
City
Pittsburg
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Facility Name
South Carolina Oncology Assoc., PA
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29210
Country
United States
Facility Name
Cancer Centers of the Carolinas
City
Easley
State/Province
South Carolina
ZIP/Postal Code
29640
Country
United States
Facility Name
Cancer Centers of the Carolinas
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29605
Country
United States
Facility Name
Cancer Centers of the Carolinas
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29615
Country
United States
Facility Name
Cancer Centers of the Carolinas, Seneca
City
Seneca
State/Province
South Carolina
ZIP/Postal Code
29672
Country
United States
Facility Name
Cancer Centers of the Carolinas
City
Spartanburg
State/Province
South Carolina
ZIP/Postal Code
29307
Country
United States
Facility Name
Cookeville Regional Medical Center
City
Cookeville
State/Province
Tennessee
ZIP/Postal Code
38501
Country
United States
Facility Name
Bostin Baskin Cancer Foundation
City
Germantown
State/Province
Tennessee
ZIP/Postal Code
38138
Country
United States
Facility Name
Tennessee Cancer Specialists
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37909
Country
United States
Facility Name
Bostin Baskin Cancer Foundation
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38104
Country
United States
Facility Name
Family Cancer Center Foundation, Inc.
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38119
Country
United States
Facility Name
West Clinic
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38120
Country
United States
Facility Name
Sarah Cannon Cancer Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Facility Name
Sarah Cannon Research Institute
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Facility Name
Texas Oncology, P.A. - Amarillo
City
Amarillo
State/Province
Texas
ZIP/Postal Code
79106
Country
United States
Facility Name
Texas Oncology Beaumont
City
Beaumont
State/Province
Texas
ZIP/Postal Code
77702-1449
Country
United States
Facility Name
Texas Oncology Texas Cancer Center at Medical City
City
Dallas
State/Province
Texas
ZIP/Postal Code
75230-2510
Country
United States
Facility Name
Baylor Charles A Sammons Cancer Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Texas Oncology - Flower Mound
City
Flower Mound
State/Province
Texas
ZIP/Postal Code
75028
Country
United States
Facility Name
Texas Oncology Southwest Forth Worth
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76132
Country
United States
Facility Name
Texas Oncology, Fort Worth
City
Ft. Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Texas Oncology, Garland
City
Garland
State/Province
Texas
ZIP/Postal Code
75042-5788
Country
United States
Facility Name
Cancer Care Centers of South Texas - HOAST
City
New Braunfels
State/Province
Texas
ZIP/Postal Code
78131
Country
United States
Facility Name
Texas Oncology - Paris
City
Paris
State/Province
Texas
ZIP/Postal Code
75460-5004
Country
United States
Facility Name
Texas Oncology - Plano East
City
Plano
State/Province
Texas
ZIP/Postal Code
75075-7787
Country
United States
Facility Name
Cancer Care Centers of South Texas-HOAST
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Texas Oncology -Tyler
City
Tyler
State/Province
Texas
ZIP/Postal Code
75702
Country
United States
Facility Name
Texas Oncology Cancer Care and Research Center
City
Waco
State/Province
Texas
ZIP/Postal Code
76712
Country
United States
Facility Name
Onc and Hem Associates of SW VA, Inc. d/b/a Blue Ridge Cancer Care
City
Christiansburg
State/Province
Virginia
ZIP/Postal Code
24073
Country
United States
Facility Name
Onc and Hem Associates of SW VA, Inc.
City
Christiansburg
State/Province
Virginia
ZIP/Postal Code
24073
Country
United States
Facility Name
Virginia Oncology Associates
City
Hampton
State/Province
Virginia
ZIP/Postal Code
23666
Country
United States
Facility Name
Virginia Oncology Associates
City
Newport News
State/Province
Virginia
ZIP/Postal Code
23606
Country
United States
Facility Name
Virginia Oncology Associates
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23502
Country
United States
Facility Name
Onc and Hem Associates of SW VA, Inc. d/b/a Blue Ridge Cancer Care
City
Roanoke
State/Province
Virginia
ZIP/Postal Code
24014
Country
United States
Facility Name
Onc and Hem Assoc of SW VA, Inc d/b/a Blue Ridge Cancer Care
City
Salem
State/Province
Virginia
ZIP/Postal Code
24153
Country
United States
Facility Name
Onc and Hem Associates of SW VA, Inc. d/b/a Blue Ridge Cancer Care
City
Wytheville
State/Province
Virginia
ZIP/Postal Code
24382
Country
United States
Facility Name
Univ. of Washington/ Seattle Cancer Care Alliance
City
Seattle
State/Province
Washington
ZIP/Postal Code
98109
Country
United States
Facility Name
Cancer Care Northwest-Valley
City
Spokane Valley
State/Province
Washington
ZIP/Postal Code
99216
Country
United States
Facility Name
Cancer Care Northwest
City
Spokane
State/Province
Washington
ZIP/Postal Code
99202
Country
United States
Facility Name
Cancer Care Northwest-North
City
Spokane
State/Province
Washington
ZIP/Postal Code
99218
Country
United States
Facility Name
Northwest Cancer Specialists, P.C.
City
Vancouver
State/Province
Washington
ZIP/Postal Code
98684
Country
United States
Facility Name
Northwest Cancer Specialist, P.C.
City
Vancouver
State/Province
Washington
ZIP/Postal Code
98686
Country
United States
Facility Name
Hospital Italiano de Buenos Aires
City
Buenos Aires
ZIP/Postal Code
C1181ACH
Country
Argentina
Facility Name
Hospital de Rehabilitación Respiratoria María Ferrer
City
Buenos Aires
ZIP/Postal Code
C1272AAA
Country
Argentina
Facility Name
COIR
City
Mendoza
ZIP/Postal Code
M5500AYB
Country
Argentina
Facility Name
Hospital Espanol de Rosario
City
Rosario, Santa Fe
ZIP/Postal Code
S2001SBL
Country
Argentina
Facility Name
ISIS Centro Especializado De Luce S.A.
City
Santa Fé
ZIP/Postal Code
S3000FFU
Country
Argentina
Facility Name
Campbelltown Hospital
City
Campbelltown
State/Province
New South Wales
ZIP/Postal Code
2560
Country
Australia
Facility Name
Liverpool Hospital
City
Liverpool
State/Province
New South Wales
ZIP/Postal Code
2170
Country
Australia
Facility Name
Royal North Shore Hospital
City
St Leonards
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Facility Name
Monash Medical Centre
City
East Bentleigh
State/Province
Victoria
ZIP/Postal Code
3165
Country
Australia
Facility Name
St Vincent's Hospital Melbourne
City
Fitzroy
State/Province
Victoria
ZIP/Postal Code
3065
Country
Australia
Facility Name
Austin Hospital
City
Heidelberg
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Facility Name
Respiratory Clinical Trials Pty., Ltd
City
Adelaide
ZIP/Postal Code
5067
Country
Australia
Facility Name
Ashford Cancer Centre
City
Ashford
ZIP/Postal Code
SA 5037
Country
Australia
Facility Name
Universitaetsklinikum Innsbruck
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
Facility Name
Allgemeines Krankenhaus der Stadt Linz
City
Linz
ZIP/Postal Code
4021
Country
Austria
Facility Name
Landeskrankenhaus SalzburgUniversitaetsklinikum der PMUUniversitaetsklinik für Pneumologie
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Facility Name
AKH Wien
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Krankenhaus Hietzing
City
Wien
ZIP/Postal Code
1130
Country
Austria
Facility Name
SMZ Baumgartner Hoehe - Otto Wagner Spital
City
Wien
ZIP/Postal Code
1140
Country
Austria
Facility Name
SMZ Baumgartner Höhe - Otto- Wagner-Spital
City
Wien
ZIP/Postal Code
A-1140
Country
Austria
Facility Name
Hôpital Erasme
City
Brussels
ZIP/Postal Code
1070
Country
Belgium
Facility Name
Cliniques Universitaires Saint-Luc
City
Brussels
ZIP/Postal Code
1200
Country
Belgium
Facility Name
Le Grand Hôpital de Charleroi
City
Charleroi
ZIP/Postal Code
6000
Country
Belgium
Facility Name
Centre Hospitalier Jolimont-Lobbes
City
La Louvière
ZIP/Postal Code
7100
Country
Belgium
Facility Name
Cross Cancer Institute
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 1Z2
Country
Canada
Facility Name
Cancer Center of Southeastern Ontario at Kingston General Hospital
City
Kingston
State/Province
Ontario
ZIP/Postal Code
K7L 5P9
Country
Canada
Facility Name
Trillium Health Partners - Credit Valley Hospital
City
Mississauga
State/Province
Ontario
ZIP/Postal Code
L5M 2N1
Country
Canada
Facility Name
Stronach Regional cancer Centre at Southlake
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 2P9
Country
Canada
Facility Name
RS MacLaughlin Durham Regional Cancer Centre
City
Oshawa
State/Province
Ontario
ZIP/Postal Code
L1G 2B9
Country
Canada
Facility Name
Sault Area Hospital
City
Sault Ste Marie
State/Province
Ontario
ZIP/Postal Code
P6A 5K7
Country
Canada
Facility Name
Thunder Bay Regional Health Science Centre
City
Thunder Bay
State/Province
Ontario
ZIP/Postal Code
P7B 6V4
Country
Canada
Facility Name
Toronto General Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 2C4
Country
Canada
Facility Name
McGill Dept. of Oncology
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2W 1S6
Country
Canada
Facility Name
Royal Victoria Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3A 1A1
Country
Canada
Facility Name
Montreal General Hospital
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3G 1A4
Country
Canada
Facility Name
St. Joseph's Health Centre
City
Toronto
ZIP/Postal Code
M6R 1B5
Country
Canada
Facility Name
Nemocnice Ceske Budejovice, a.s.
City
Ceske Budejovice
ZIP/Postal Code
370 87
Country
Czech Republic
Facility Name
Fakultni nemocnice OstravaKlinika tuberkulozy a respiracnich nemoci
City
Ostrava-Poruba
ZIP/Postal Code
70852
Country
Czech Republic
Facility Name
FN Bulovka Klinika plincni a hrrudni chirurgie
City
Praha
ZIP/Postal Code
8 18081
Country
Czech Republic
Facility Name
CHU Larrey Service de Pneumologie, Clinique des voies respiratoires
City
Toulouse
State/Province
Cedex 9
ZIP/Postal Code
31059
Country
France
Facility Name
Centre d'Oncologie et de Radiothérapie du Pays Basque
City
Bayonne
ZIP/Postal Code
64100
Country
France
Facility Name
C.H.U. Morvan, Institut de Cancerologie et d'Hématologie
City
Brest cedex
ZIP/Postal Code
29609
Country
France
Facility Name
CHU de Caen - Service de pneumologie
City
Caen Cedex
ZIP/Postal Code
14033
Country
France
Facility Name
CHU Clermont Ferrand - Hôpital Gabriel Montpied - Service de pneumologie
City
Clermont-Ferrand cedex 1
ZIP/Postal Code
63003
Country
France
Facility Name
Hopital De La Croix-Rousse Service de Pneumologie
City
Lyon cedex 04
ZIP/Postal Code
69317
Country
France
Facility Name
Institut Paoli-Calmettes
City
Marseille cedex 9
ZIP/Postal Code
13273
Country
France
Facility Name
Fondation Hôpital Saint Joseph
City
PARIS cedex 14
ZIP/Postal Code
75014
Country
France
Facility Name
Hôpital de Tenon
City
Paris
ZIP/Postal Code
75012
Country
France
Facility Name
Centre Catalan d'Oncologie
City
Perpignan
ZIP/Postal Code
66000
Country
France
Facility Name
CHU - Hopital Pontchaillou - Service de pneumologie
City
Rennes cedex 9
ZIP/Postal Code
35033
Country
France
Facility Name
Institut de Cancérologie de la Loire
City
Saint Priest en Jarez
ZIP/Postal Code
42271
Country
France
Facility Name
Hôpital de Brabois
City
Vandoeuvre-lès-Nancy Cedex
ZIP/Postal Code
54511
Country
France
Facility Name
Zentralklinik Bad Berka
City
Bad Berka
ZIP/Postal Code
99437
Country
Germany
Facility Name
HELIOS Klinikum Emil von Behring GmbH
City
Berlin
ZIP/Postal Code
14165
Country
Germany
Facility Name
Augusta-Krankenanstalt Bochum
City
Bochum
ZIP/Postal Code
44791
Country
Germany
Facility Name
Fachkrankenhaus Coswig
City
Coswig
ZIP/Postal Code
01640
Country
Germany
Facility Name
Universitaetsklinikum Essen
City
Essen
ZIP/Postal Code
45122
Country
Germany
Facility Name
Krankenhaus Nordwest
City
Frankfurt/Main
ZIP/Postal Code
60488
Country
Germany
Facility Name
Universitätsklinikum Freiburg
City
Freiburg
ZIP/Postal Code
79106
Country
Germany
Facility Name
Lungenclinic Großhansdorf
City
Großhansdorf
ZIP/Postal Code
22927
Country
Germany
Facility Name
Universitätsklinikum Göttingen
City
Göttingen
ZIP/Postal Code
37075
Country
Germany
Facility Name
Städtisches Krankenhaus Martha-Maria, Halle-Dölau
City
Halle (Saale)
ZIP/Postal Code
06120
Country
Germany
Facility Name
Asklepios Klinik Harburg
City
Hamburg
ZIP/Postal Code
21075
Country
Germany
Facility Name
Thoraxklinik Heidelberg
City
Heidelberg
ZIP/Postal Code
69126
Country
Germany
Facility Name
Lungenklink Hemer des Deutschen Gemeinschafts-Diakonieverbandes GmbH
City
Hemer
ZIP/Postal Code
58675
Country
Germany
Facility Name
St. Vincentius-Kliniken Karlsruhe
City
Karlsruhe
ZIP/Postal Code
76137
Country
Germany
Facility Name
Universitaetsklinikum Schleswig-Holstein
City
Lübeck
ZIP/Postal Code
23538
Country
Germany
Facility Name
Universitätsklinikum Mainz
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Asklepios Klinikum Gauting
City
Muenchen-Gauting
ZIP/Postal Code
82131
Country
Germany
Facility Name
Pius Hospital Oldenburg
City
Oldenburg
ZIP/Postal Code
26121
Country
Germany
Facility Name
Schwarzwald-Baar Klinikum
City
Villingen-Schwenningen
ZIP/Postal Code
78050
Country
Germany
Facility Name
IASO GENERAL Hospital of Athens
City
Athens
ZIP/Postal Code
15562
Country
Greece
Facility Name
"Papageorgiou" General Hospital of Thessaloniki
City
Thessaloniki
ZIP/Postal Code
54603
Country
Greece
Facility Name
"G. Papanikolaou" General Hospital of Thessaloniki
City
Thessaloniki
ZIP/Postal Code
57010
Country
Greece
Facility Name
Országos Korányi TBC és Pulmonológiai Intézet
City
Budapest
ZIP/Postal Code
1121
Country
Hungary
Facility Name
Semmelweis Egyetem Altalanos Orvostudomanyi Kar Pulmonologiai Klinika
City
Budapest
ZIP/Postal Code
1125
Country
Hungary
Facility Name
Csongrad Megyei Onkormanyzat, Mellkasi Betegsegek Szakkorhaza
City
Deszk
ZIP/Postal Code
6772
Country
Hungary
Facility Name
Pecsi Tudomany Egyete m Klinikai Kozpont, I.sz Belgyogyaszati Klinika Pulmonologiai Munkacsoport
City
Pécs
ZIP/Postal Code
7623
Country
Hungary
Facility Name
Fejer Megyei Szent Gyorgy Korhaz
City
Szekesfehervar
ZIP/Postal Code
8000
Country
Hungary
Facility Name
Vas Megyei Markusovszky Lajos Altalanos Rehabilitacios es Gyogyfurdo Korhaz, Egyetemi Oktatoko Zarkoruen Mukodo Nonprofit Reszveny Tarsasag
City
Szombathely
ZIP/Postal Code
9700
Country
Hungary
Facility Name
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I
City
Ancona
ZIP/Postal Code
60020
Country
Italy
Facility Name
Ospedale Bellaria
City
Bologna
ZIP/Postal Code
40139
Country
Italy
Facility Name
Ospedale Garibaldi Nesima
City
Catania
ZIP/Postal Code
95100
Country
Italy
Facility Name
Istituto Nazionale per la Ricerca e la Cura del Cancro
City
Genova
ZIP/Postal Code
16132
Country
Italy
Facility Name
Azienda Ospedaliero- Universitaria di Parma
City
Parma
ZIP/Postal Code
43100
Country
Italy
Facility Name
Ospedale S. Maria della Misericordia
City
Perugia
ZIP/Postal Code
06132
Country
Italy
Facility Name
Azienda Ospedaliera San Camillo Forlanini
City
Roma
ZIP/Postal Code
00152
Country
Italy
Facility Name
Saint Vincent's Hospital
City
Gyeonggi-Do
ZIP/Postal Code
442-723
Country
Korea, Republic of
Facility Name
Gachon Medical School Ghil Medical Center
City
Incheon
ZIP/Postal Code
405-760
Country
Korea, Republic of
Facility Name
Seoul National University Hospital
City
Seoul
ZIP/Postal Code
110-744
Country
Korea, Republic of
Facility Name
Severance Hospital, Yonsei Univ. College of Medicine
City
Seoul
ZIP/Postal Code
120-752
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
138-736
Country
Korea, Republic of
Facility Name
Samodzielny Publiczny Szpital Kliniczny Nr 4
City
Lublin
ZIP/Postal Code
20-954
Country
Poland
Facility Name
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy
City
Otwock
ZIP/Postal Code
05-400
Country
Poland
Facility Name
Wielkoposkie Centrum Pulmonologii i Torakochirurgii, Oddzial Onkologii Klinicznej z Pododdzialem Dziennej Chemioterapii
City
Poznan
ZIP/Postal Code
60-569
Country
Poland
Facility Name
Specjalistyczny Szpital im. prof.Alfreda Sokolowskiego
City
Szczecin
ZIP/Postal Code
70-891
Country
Poland
Facility Name
Centrum Onkologii - Instytut im. Marii Skllodowskiej - Curie
City
Warsaw
ZIP/Postal Code
02-781
Country
Poland
Facility Name
Dolnoslaskie Centrum Chorob Pluc we Wroclawiu, Katedra i Klinika Pulmonologii i Nowotworow Pluc Akademii Medycznej
City
Wroclaw
ZIP/Postal Code
53-439
Country
Poland
Facility Name
Spitalui Clinic Judetean de Urgenta, Sectia de Oncologie
City
Oradea
State/Province
Bihor
ZIP/Postal Code
410032
Country
Romania
Facility Name
Oncoloab SRL
City
Craiova
State/Province
Dolj
ZIP/Postal Code
200535
Country
Romania
Facility Name
Institutul Oncologic Al. Trestioreanu Sectia Oncologie Medicala II
City
Bucuresti
ZIP/Postal Code
022328
Country
Romania
Facility Name
Institutul Oncologic Al. Trestioreanu
City
Bucuresti
ZIP/Postal Code
022328
Country
Romania
Facility Name
Institutul Oncologic Prof. Dr. Ion Chiricuta
City
Cluj-Napoca
ZIP/Postal Code
400015
Country
Romania
Facility Name
Centrul de Oncologie Medicala
City
Iasi
ZIP/Postal Code
700106
Country
Romania
Facility Name
Spitalul Clinic Judetean Sibiu
City
Sibiu
ZIP/Postal Code
550245
Country
Romania
Facility Name
State Healthcare Institution "Arkhangelsk Regional Clinical Oncology Dispensary"
City
Arkhangelsk
ZIP/Postal Code
163045
Country
Russian Federation
Facility Name
State Healthcare Institution "Regional Clinical Oncology Dispensary"
City
Kemerovo
ZIP/Postal Code
650036
Country
Russian Federation
Facility Name
State Healthcare Institution "Region Clinical Hospital # 1 n.a. professor S.V. Ochapovsky"
City
Krasnodar
ZIP/Postal Code
350086
Country
Russian Federation
Facility Name
State Institution "Central Military Clinical Hospital n.a. academician N.N. Burdenko under the Ministry of Defense of Russia"
City
Moscow
ZIP/Postal Code
105229
Country
Russian Federation
Facility Name
Institution of the RAMS "Russian Oncology Scientific Centre n.a. N.N. Blokhin under the Russian Academy of Medical Sciences"
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
State Educational Institution of Higher Professional Education "Saint-Petersburg State Medical University n.a. ac. I.P. Pavlov of the Ministry of Healthcare and Social Development of the Russian Federation"
City
Saint-Petersburg
ZIP/Postal Code
197022
Country
Russian Federation
Facility Name
Federal State Institution "Petrov Scientific Research Institute of Oncology of Rosmedtechnology"
City
Saint-Petersburg
ZIP/Postal Code
197758
Country
Russian Federation
Facility Name
Saint-Petersburg State Healthcare Institution "City Clinical Oncology Dispensary"
City
Saint-Petersburg
ZIP/Postal Code
198255
Country
Russian Federation
Facility Name
Regional State Budget Healthcare Instiution"Tomsk Regional Oncology Dispensary"
City
Tomsk
ZIP/Postal Code
634050
Country
Russian Federation
Facility Name
State Healthcare Institution of Yaroslavl Region "Regional Clinical Oncology Hospital"
City
Yaroslavl
ZIP/Postal Code
150040
Country
Russian Federation
Facility Name
ICO (Institut Catalá d´Oncología)
City
L' Hospitalet de Llobregat
State/Province
Barcelona
ZIP/Postal Code
08907
Country
Spain
Facility Name
Fundació Althaia
City
Manresa
State/Province
Barcelona
ZIP/Postal Code
08243
Country
Spain
Facility Name
Corporació Sanitaria Parc Taulí
City
Sabadell
State/Province
Barcelona
ZIP/Postal Code
08208
Country
Spain
Facility Name
Hospital Puerta de Hierro Majadahonda
City
Majadahonda
State/Province
Madrid
ZIP/Postal Code
28222
Country
Spain
Facility Name
Hospital Oncologico MD Anderson
City
Madrid
ZIP/Postal Code
28033
Country
Spain
Facility Name
Hospital Universitario 12 de Octubre
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
Hospital Universitario La Paz
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Hospital Carlos Haya
City
Málaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Hospital Clínico Virgen de la Victoria
City
Málaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Clinica Universitaria de Navarra
City
Pamplona
ZIP/Postal Code
31008
Country
Spain
Facility Name
Hospital Universitario Marques de Valdecilla
City
Santander
ZIP/Postal Code
39008
Country
Spain
Facility Name
Hospital Universitario de Valme
City
Sevilla
ZIP/Postal Code
41700
Country
Spain
Facility Name
Hospital Virgen de la Salud de Toledo
City
Toledo
ZIP/Postal Code
45004
Country
Spain
Facility Name
Hospital General Universitario de Valencia
City
Valencia
ZIP/Postal Code
46014
Country
Spain
Facility Name
Changhua Christian Hospital
City
Changhua
ZIP/Postal Code
500-06
Country
Taiwan
Facility Name
Chang Gung Medical Foundation
City
Kaohsiung
ZIP/Postal Code
833
Country
Taiwan
Facility Name
Chung Shan Medical University Hospital
City
Taichung
ZIP/Postal Code
402
Country
Taiwan
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
404
Country
Taiwan
Facility Name
Taichung Veterans General Hospital
City
Taichung
ZIP/Postal Code
407
Country
Taiwan
Facility Name
Taipei Veterans General Hospital
City
Taipei
ZIP/Postal Code
112
Country
Taiwan
Facility Name
Chang Gung Memorial Hospital
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Birmingham Heartlands Hospital
City
Birmingham
ZIP/Postal Code
B9 5SS
Country
United Kingdom
Facility Name
Bristol Haematology and Oncology Centre
City
Bristol
ZIP/Postal Code
BS2 8ED
Country
United Kingdom
Facility Name
Ninewells Hospital
City
Dundee
ZIP/Postal Code
DD1 9SY
Country
United Kingdom
Facility Name
Beatson West of Scotland Cancer Centre
City
Glasgow
ZIP/Postal Code
G12 0YN
Country
United Kingdom
Facility Name
The Royal Surrey County Hospital NHS Trust
City
Guildford
ZIP/Postal Code
GU2 7XX
Country
United Kingdom
Facility Name
Leicester Royal Infirmary
City
Lecester
ZIP/Postal Code
LE1 5WW
Country
United Kingdom
Facility Name
St James' Institute of Oncology, Bexley Wing, St James' University Hospital
City
Leeds
ZIP/Postal Code
LS9 7TF
Country
United Kingdom
Facility Name
Guy's Hospital
City
London
ZIP/Postal Code
SE1 9RT
Country
United Kingdom
Facility Name
Royal Marsden Hospital
City
London
ZIP/Postal Code
SW3 6JJ
Country
United Kingdom
Facility Name
Royal Marsden Hospital
City
Sutton
ZIP/Postal Code
SM2 5PT
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
26324372
Citation
Kelly K, Altorki NK, Eberhardt WE, O'Brien ME, Spigel DR, Crino L, Tsai CM, Kim JH, Cho EK, Hoffman PC, Orlov SV, Serwatowski P, Wang J, Foley MA, Horan JD, Shepherd FA. Adjuvant Erlotinib Versus Placebo in Patients With Stage IB-IIIA Non-Small-Cell Lung Cancer (RADIANT): A Randomized, Double-Blind, Phase III Trial. J Clin Oncol. 2015 Dec 1;33(34):4007-14. doi: 10.1200/JCO.2015.61.8918. Epub 2015 Aug 31.
Results Reference
derived
Links:
URL
https://www.astellasclinicalstudyresults.com/study.aspx?ID=OSI-774-302
Description
Link to results on Astellas Clinical Study Results website

Learn more about this trial

A Study of Erlotinib (Tarceva) After Surgery With or Without Adjuvant Chemotherapy in Non-Small Cell Lung Carcinoma (NSCLC) Patients Who Have Epidermal Growth Factor Receptor (EGFR) Positive Tumors

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