Muscle Contraction in Patients With Focal Hand Dystonia
Focal Hand Dystonia
About this trial
This is an observational trial for Focal Hand Dystonia focused on measuring Transcranial Magnetic Stimulation (TMS), Writer's Cramp, Electromyogram, Focal Hand Dystonia, FHD, Healthy Volunteer, HV
Eligibility Criteria
- INCLUSION CRITERIA:
PATIENTS:
18 years old or older
Presence of FHD, for Experiment 5, 6, 7 and 8 the affected limb has to be the right and dominant side
HEALTHY VOLUNTEERS:
18 years old or older
Right handedness
Absence of dystonia or other neurological disorder with any effect on the motor or sensory systems
EXCLUSION CRITERIA:
PATIENTS AND HEALTHY VOLUNTEERS:
Concurrent significant medical, surgical, neurological or psychiatric condition
Taking the following medications: antidepressants, anxiolytics, anticonvulsants, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines
Patients- Received botulinum toxin injection within 3 months of starting the protocol
For TMS: Presence of pacemaker, implanted medical pump, metal plate or metal object in skull or eye
History of seizure disorder
Known history of hearing loss
For MRI: Presence of pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips, metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pumps, or shrapnel fragments. Welders and metal workers are also at risk for injury because of possible small metal fragments in the eye of which they may be unaware.
Pregnancy.
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike