PET Scan and CT Scan in Evaluating Response in Patients Undergoing Radiofrequency Ablation for Lung Metastases (TEPARF)
Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
About this trial
This is an interventional diagnostic trial for Metastatic Cancer focused on measuring unspecified adult solid tumor, protocol specific, lung metastases
Eligibility Criteria
DISEASE CHARACTERISTICS:
- Histologically confirmed cancer
Radiologically suspected pulmonary metastases
- May be confirmed histologically or by specific markers
- Less than 6 lesions
- Lesions < 40 mm
- Prior positron emission tomography shows 1 hyperfixation (standard uptake variable > 3) at the level of lesions to be treated
- Lesions must not be attached to or next to major mediastinal structures
- Radiofrequency ablation planned as treatment
PATIENT CHARACTERISTICS:
- Life expectancy > 6 months
No uncontrolled medical condition, including any of the following:
- Psychiatric condition
- Infection
- Coronary insufficiency
- New York Heart Association class III-IV heart disease
- No other serious condition
- No contraindication to general anesthesia
- Not pregnant or nursing
PRIOR CONCURRENT THERAPY:
- At least 30 days since prior participation in an investigational study
- At least 30 days since prior chemotherapy
- No other concurrent investigational agents
Sites / Locations
- Centre Hospitalier de la Cote Basque
- Institut Bergonie
- Hopital Haut Leveque
Arms of the Study
Arm 1
Experimental
18F-FDG PET/CT + RFA
18F-FDG PET/CT: I.V. injection of 5 to 15 mCi (185 to 555 MBq) of 18F-FDG. Capture time of 60 to 90 minutes. Acquisition of images: A whole body CT scan with normal breathing will be performed for attenuation correction with 5mm thick slices. A whole body PET acquisition of 6 or 7 steps will be done from the upper third of the thighs to the base of the skull. PETC/CT performed at inclusion, 1 month et 3 months after RFA. RFA: Treatment procedure: the location under scanner allows to place the electrode in the center of the tumor. The treatment then lasts 15 to 20 minutes. CT scanner: The CT examination will be performed in spiral acquisition without or after injection of contrast medium (70 ml at 2 or 3 ml/sec). On a 16-slice scanner, the examination is performed with 1.25 mm slices every 0.9. Constants generally used 120kV, 350 mA. Ct scanner performed at inclusion, 48H post-RFA, 1 month, 3 months, 6, 9 and 12 months after RFA.