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Tegafur-Uracil or Observation in Treating Patients With Stage II Colorectal Cancer That Has Been Completely Removed By Surgery

Primary Purpose

Colorectal Cancer

Status
Completed
Phase
Phase 3
Locations
Japan
Study Type
Interventional
Intervention
UFT adjuvant chemotherapy
Sponsored by
Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Colorectal Cancer focused on measuring stage II colon cancer, stage II rectal cancer, adenocarcinoma of the colon, adenocarcinoma of the rectum

Eligibility Criteria

20 Years - 80 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

DISEASE CHARACTERISTICS:

  • Histologically confirmed adenocarcinoma of the colon or rectosigmoid

    • Stage II disease
  • Has undergone curative (R0) resection within the past 8 weeks
  • No suspicion of hereditary colorectal cancer
  • No severe postoperative complications

PATIENT CHARACTERISTICS:

  • ECOG performance status 0-1
  • WBC 3,500-12,000/mm³
  • Absolute neutrophil count ≥ 1,500/mm³
  • Platelet count ≥ 100,000/mm³
  • Hemoglobin ≥ 9.0 g/dL
  • Bilirubin ≤ 2.0 mg/dL
  • AST and ALT ≤ 100 IU/L
  • Creatinine ≤ 1.5 mg/dL
  • Not pregnant or nursing
  • Able to take oral medications
  • Major organ functions are preserved
  • No other active malignancy

  • None of the following conditions:

    • Uncontrolled diabetes mellitus
    • Uncontrolled hypertension
    • Myocardial infarction or unstable angina pectoris within the past 6 months
    • Liver cirrhosis
    • Interstitial pneumonia
    • Pulmonary fibrosis
    • Severe emphysema
  • No psychiatric disease or other condition that would preclude study participation

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • No prior chemotherapy
  • No prior or concurrent radiotherapy
  • No concurrent prophylactic growth factors
  • No concurrent biologic response modifiers

Sites / Locations

  • Aichi Medical University
  • Japanese Red Cross Nagoya First Hospital
  • Nagoya City University Hospital
  • Nagoya Central Hospital
  • Nagoya Ekisaikai Hospital
  • Ban Buntane Houtokukai Hospital
  • West Medical Center Jouhoku Municipal Hospital
  • Aichi Cancer Center
  • Nagoya University Hospital
  • Nagoya University School of Medicine
  • Nagoya Midori Municipal Hospital
  • Aichi Cancer Center at Aichi Hospital
  • National Hospital Organization Toyohashi Medical Center
  • Toyohashi Municipal Hospital
  • Koseiren Kamo Hospital
  • Yamamoto Kumiai General Hospital
  • Hiraka General Hospital
  • Asahi General Hospital
  • Teikyo University Chiba Medical Center
  • Juntendo Urayasu Hospital
  • Shikoku Cancer Center
  • Sumitomo Besshi Hospital
  • Fukuiken Saiseikai Hospital
  • University of Fukui Hospital
  • Kyushu University Hospital
  • University of Occupational and Environmental Health
  • Kitakyushu Municipal Medical Center
  • Kurume University School of Medicine
  • Saint Mary's Hospital
  • Social Insurance Tagawa Hospital
  • Fukushima Medical University Hospital
  • Gifu Municipal Hospital
  • Hashima City Hospital
  • Ogaki Municipal Hospital
  • Gunma University Graduate School of Medicine
  • Gunma Cancer Center
  • National Hospital Organization Fukuyama Medical Center
  • Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers
  • National Hospital Organization Kure Medical Center
  • Miyoshi Central Hospital
  • Asahikawa Medical College
  • Otaru Ekisaikai Hospital
  • Hakodate Goryoukaku Hospital
  • Hirosaki University, School of Medicine
  • Sapporo-Kosei General Hospital
  • Sapporo Medical University
  • Sapporo City General Hospital
  • Hokkaido University Graduate School of Medicine
  • Akashi Municipal Hospital
  • Hyogo Cancer Center
  • Ako City Hospital
  • Hyogo Prefectural Amagasaki Hospital
  • Kansai Rosai Hospital
  • Himeji St. Mary's Hospital
  • Himeji Central Hospital
  • Kinki Central Hospital
  • Kakogawa Municipal Hospital
  • Kobe City General Hospital
  • Kobe University Hospital
  • Shakai Hoken Kobe Central Hospital
  • Nishi-Kobe Medical Center
  • Kobe West City Hospital
  • Kobe Medical Center
  • Sano Hospital
  • Hyogo College of Medicine
  • Hyogo Prefectural Awaji Hospital
  • Higashi Takarazuka Satoh Hospital
  • Takarazuka Municipal Hospital
  • Public Shiso General Hospital
  • Mito Saiseikai General Hospital
  • Tsuchiura Kyodo General Hospital
  • Kanazawa Medical University
  • Kanazawa University Hospital
  • Iwate Medical University Hospital
  • Iwate Prefectural Central Hospital
  • Kagawa Rosai Hospital
  • Kagawa University Hospital
  • Kagawa Prefectural Central Hospital
  • Kanagawa Prefectural Ashigawa-kami Hospital
  • Chigasaki Municipal Hospital
  • Fujisawa City Hospital
  • Kanto Rosai Hospital
  • Nippon Medical School Musashikosugi Hospital
  • Saint Marianna University School of Medicine
  • Sagamihara National Hospital
  • Showa University Northern Yokohama Hospital
  • Showa University Fujigaoka Hospital
  • Social Insurance Yokohama Central Hospital
  • Yokohama City University Medical Center
  • Saiseikai Yokohama City Nanbu Hospital
  • Yokohama City Hospital
  • St. Marianna University Yokohama City Seibu Hospital
  • Kanagawa Cancer Center
  • International Goodwill Hospital
  • Yokosuka Kyosai Hospital
  • Kochi Medical School
  • National Hospital Organization - Kumamotominami Hospital
  • Japan Labor Health and Welfare Organization Kumamoto Rosai Hospital
  • Yatsushiro Health Insurance General Hospital
  • Kyoto First Red Cross Hospital
  • Kyoto Second Red Cross Hospital
  • Nantan General Hospital
  • Kyoto University Hospital
  • Mie University Graduate School of Medicine
  • Miyagi Cancer Center
  • Sendai Kousei Hospital
  • Tohoku University Graduate School of Medicine
  • Tohoku Rosai Hospital
  • Sendai Medical Center
  • Iida Municipal Hospital
  • Showa-Inan General Hospital
  • Aizawa Hospital
  • Nagano Municipal Hospital
  • Hokushin Hospital
  • Nagasaki University Hospital
  • Japanese Red Cross Nagasaki Genbaku Hospital
  • National Hospital Organization Nagasaki Medical Center
  • Sasebo City General Hospital
  • Nara Medical University Cancer Center
  • Kenseikai Nara Coloproctology Center
  • Nagaoka Chuo General Hospital
  • Niigata University Medical and Dental Hospital
  • Niigata Cancer Center Hospital
  • Oita University Hospital
  • Kawasaki Medical School
  • Kurashiki Central Hospital
  • Hoshigaoka Koseinenkin Hospital
  • Izumiotsu Municipal Hospital
  • Rinku General Medical Center
  • Minoh City Hospital
  • Kansai Medical University Takii Hospital
  • Osaka City General Hospital
  • Osaka Police Hospital
  • Osaka Kosei Nenkin Hospital
  • Osaka General Medical Center
  • Kinki University School of Medicine
  • Osaka Rosai Hospital
  • Sakai Municipal Hospital
  • Bell Land General Hospital
  • Suita Municipal Hospital
  • Osaka Medical College
  • Saiseikai Tondabayashi Hospital
  • Fukaya Red Cross Hospital
  • Hasuda Hospital
  • Saitama Medical University International Medical Center
  • Saitama Medical School Hospital
  • Kitasato Institute Medical Center Hospital
  • Omiya Medical Center ofJichi Medical School
  • National Hospital Organization - Nishisaitama-Chuo National Hospital
  • National Defense Medical College
  • Shiga University of Medical Science
  • Otsu Municipal Hospital
  • Shimane Prefectural Central Hospital
  • Fujieda Municipal General Hospital
  • Hamamatsu University School of Medicine
  • Shizuoka Cancer Center
  • Yaizu Municipal Hospital
  • Ohtawara Red Cross Hospital
  • Dokkyo University School of Medicine
  • Jichi Medical School
  • Tochigi Cancer Center
  • Anan Kyoei Hospital
  • Juntendo University School of Medicine
  • St. Luke's International Hospital
  • Tokyo Metropolitan Fuchu Hospital
  • Higashiyamato General Hospital
  • Tokyo-Kita Social Insurance Hospital
  • Showa General Hospital
  • Daisan Hospital
  • Toho University Ohashi Hospital
  • Toranomon Hospital
  • Kyorin University School of Medicine - Mitaka Campus
  • Nakano General Hospital
  • Social Insurance Chuo General Hospital
  • Tokyo Women's Medical University
  • Tottori University - Faculty of Medicine
  • Koseiren Takaoka Hospital
  • Toyama Prefectural Central Hospital
  • Shingu Municipal Medical Center
  • Social Insurance Kinan Hospital
  • Wakayama Medical University
  • National Hospital Organization - Kanmon Medical Center
  • Shimonoseki Kosei Hospital
  • Yamaguchi University Graduate School of Medicine
  • University of Yamanashi Faculty of Medicine
  • Ageo Central General Hospital
  • Saiseikai Hiroshima Hospital
  • Akita Kumiai General Hospital
  • Aomori City Hospital
  • Chiba Cancer Center
  • Chiba University
  • Northern Fukushima Medical Center
  • National Hospital Organization Kyushu Medical Center
  • National Kyushu Cancer Center
  • Matsunami General Hospital
  • Chugoku Electric Power Hospital
  • Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital
  • Hiroshima Prefectural Hospital
  • Hiroshima University Hospital
  • National Hospital Organization Mito Medical Center
  • Hokkaido Chuo Rosai Hospital
  • Nanpuh Hospital
  • Kitasato University School of Medicine
  • Osaka Minami Medical Center
  • Kiryu Kosei General Hospital
  • Kobe Ekisaikai Hospital
  • Kochi Health Sciences Center
  • Konan Kosei Hospital
  • Southern TOHOKU research Institute for Neuroscience
  • Kumamoto University Faculty of Medical and Pharmaceutical Sciences
  • Japanese Red Cross Kumamoto Hospital
  • Kyoto Prefectural University of Medicine
  • Nishijin Hospital
  • National Hospital Organization - Kyoto Medical Center
  • Kyoto-Katsura Hospital
  • Saiseikai Matsusaka General Hospital
  • Muroran City General Hospital
  • Kyoritsu General Hospital
  • Nakatsu Municipal Hospital
  • Saiseikai Nara Hospital
  • Nara Prefectual Nara Hospital
  • Saiseikai Niigata Daini Hospital
  • Numazu City Hospital
  • Oita Prefectural Hospital
  • Oita Red Cross Hospital
  • Almeida Memorial Hospital
  • Okayama University Medical School
  • Nakagami Hospital
  • Kitano Hospital
  • Osaka City Juso Hospital
  • Yodogawa Christian Hospital
  • Osaka Saiseikai Noe Hospital
  • Otemae Hospital
  • Osaka Red Cross Hospital
  • NTT West Osaka Hospital
  • Higashi Sumiyoshi Morimoto Hospital
  • Nissay Hospital
  • Minamiosaka Hospital
  • Saga Prefectural Hospital Koseikan
  • Saitama Social Insurance Hospital
  • Hakodate Municipal Hospital
  • Miyagi Social Insurance Hospital
  • Japanese Red Cross Sendai Hospital
  • Shizuoka City Hospital
  • Shizuoka Municipal Shimizu Hospital
  • Kawakita General Hospital
  • Niigata Prefectural Tokamachi Hospital
  • Tokushima University Hospital
  • Mita Hospital at the International University of Health and Welfare
  • Tokyo Medical and Dental University
  • Nippon Medical School
  • Tokyo Metropolitan - Komagome Hospital
  • Tokyo Women's Medical University Medical Center East
  • Metropolitan Bokutoh Hospital
  • Showa University Toyosu Hospital
  • NTT Kanto Medical Center
  • Toho University School of Medicine
  • Japanese Red Cross Medical Center
  • National Hospital Organization - Tokyo Medical Center
  • International Medical Center of Japan
  • Teikyo University School of Medicine
  • Jikei University School of Medicine Hospital
  • Takasago Kyoritsu Hospital
  • Toyama Red Cross Hospital
  • Japanese Red Cross Society
  • Japan Labor Health and Welfare Organization Wakayama Rosai Hospital
  • Yamagata Prefectural Central Hospital
  • Yamagata Saisei Hospital
  • Yamagata University Hospital
  • Saiseikai Yokohamashi Tobu Hospital
  • Yokohama City Minato Red Cross Hospital
  • Hitachi Yokohama Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

No Intervention

Arm Label

UFT adjuvant therapy group

Observation group

Arm Description

UFT is given at a dose of 500-600 mg/day as tegafur in 2 divided doses after meals for 5 days, followed by a 2-day rest. This one-week cycle is repeated for one year. During protocol treatment, clinical findings and laboratory values are evaluated every month. After the completion of protocol treatment, patients are followed-up, according to the schedule defined in the study protocol, for 5 years until recurrence, other malignancy or death is confirmed.

Patients are followed-up without adjuvant treatment, according to the schedule defined in the study protocol, for 5 years until recurrence, other malignancy or death is confirmed.

Outcomes

Primary Outcome Measures

Disease-free survival
Disease-free survival is defined as the time from date of enrollement until date of recurrence, other malignancies or death from any cause, whichever comes first.

Secondary Outcome Measures

Overall survival
Overall survival is defined as time from date of enrollment until date of death from any cause.
Types and severities of adverse events
Types and severities of adverse events from date of starting protocol treatment until 30 days after date of finishing the treatment are evaluated according to Japanese version of the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0 (CTCAE v3.0) by Translational Research Informatics Center.

Full Information

First Posted
October 25, 2006
Last Updated
September 26, 2016
Sponsor
Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Collaborators
Tokyo Medical and Dental University
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1. Study Identification

Unique Protocol Identification Number
NCT00392899
Brief Title
Tegafur-Uracil or Observation in Treating Patients With Stage II Colorectal Cancer That Has Been Completely Removed By Surgery
Official Title
Randomized Phase III Trial of Adjuvant Chemotherapy With UFT vs. Observation in Curatively Resected Stage II Colon Cancer
Study Type
Interventional

2. Study Status

Record Verification Date
July 2009
Overall Recruitment Status
Completed
Study Start Date
October 2006 (undefined)
Primary Completion Date
October 2015 (Actual)
Study Completion Date
September 2016 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Collaborators
Tokyo Medical and Dental University

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
RATIONALE: Drugs used in chemotherapy, such as tegafur-uracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving chemotherapy after surgery may kill any tumor cells that remain after surgery. Sometimes, after surgery, the tumor may not need more treatment until it progresses. In this case, observation may be sufficient. It is not yet known whether chemotherapy is more effective than observation in treating colorectal cancer. PURPOSE: This randomized phase III trial is studying tegafur and uracil to see how well they work compared to observation in treating patients with stage II colorectal cancer that has been completely removed by surgery.
Detailed Description
OBJECTIVES: Primary Compare the efficacy of adjuvant tegafur-uracil vs observation only in patients with curatively resected stage II colorectal cancer. Secondary Compare relapse-free and overall survival of patients treated with these regimens. Compare the occurrence of adverse events in patients treated with these regimens. OUTLINE: This is a randomized, controlled study. Patients are randomized to 1 of 2 treatment arms. Arm I: Patients undergo observation. Arm II: Patients receive oral tegafur-uracil on days 1-5. Treatment repeats every 7 days for 1 year in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed periodically for 5 years. PROJECTED ACCRUAL: A total of 2,000 patients will be accrued for this study.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Colorectal Cancer
Keywords
stage II colon cancer, stage II rectal cancer, adenocarcinoma of the colon, adenocarcinoma of the rectum

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
2025 (Actual)

8. Arms, Groups, and Interventions

Arm Title
UFT adjuvant therapy group
Arm Type
Active Comparator
Arm Description
UFT is given at a dose of 500-600 mg/day as tegafur in 2 divided doses after meals for 5 days, followed by a 2-day rest. This one-week cycle is repeated for one year. During protocol treatment, clinical findings and laboratory values are evaluated every month. After the completion of protocol treatment, patients are followed-up, according to the schedule defined in the study protocol, for 5 years until recurrence, other malignancy or death is confirmed.
Arm Title
Observation group
Arm Type
No Intervention
Arm Description
Patients are followed-up without adjuvant treatment, according to the schedule defined in the study protocol, for 5 years until recurrence, other malignancy or death is confirmed.
Intervention Type
Drug
Intervention Name(s)
UFT adjuvant chemotherapy
Other Intervention Name(s)
Adjuvant chemotherapy with tegafur-uracil
Intervention Description
UFT is given at a dose of 500-600 mg/day as tegafur in 2 divided doses after meals for 5 days, followed by a 2-day rest. This one-week cycle is repeated for one year.
Primary Outcome Measure Information:
Title
Disease-free survival
Description
Disease-free survival is defined as the time from date of enrollement until date of recurrence, other malignancies or death from any cause, whichever comes first.
Time Frame
9 years
Secondary Outcome Measure Information:
Title
Overall survival
Description
Overall survival is defined as time from date of enrollment until date of death from any cause.
Time Frame
9 years
Title
Types and severities of adverse events
Description
Types and severities of adverse events from date of starting protocol treatment until 30 days after date of finishing the treatment are evaluated according to Japanese version of the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0 (CTCAE v3.0) by Translational Research Informatics Center.
Time Frame
15 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed adenocarcinoma of the colon or rectosigmoid Stage II disease Has undergone curative (R0) resection within the past 8 weeks No suspicion of hereditary colorectal cancer No severe postoperative complications PATIENT CHARACTERISTICS: ECOG performance status 0-1 WBC 3,500-12,000/mm³ Absolute neutrophil count ≥ 1,500/mm³ Platelet count ≥ 100,000/mm³ Hemoglobin ≥ 9.0 g/dL Bilirubin ≤ 2.0 mg/dL AST and ALT ≤ 100 IU/L Creatinine ≤ 1.5 mg/dL Not pregnant or nursing Able to take oral medications Major organ functions are preserved No other active malignancy None of the following conditions: Uncontrolled diabetes mellitus Uncontrolled hypertension Myocardial infarction or unstable angina pectoris within the past 6 months Liver cirrhosis Interstitial pneumonia Pulmonary fibrosis Severe emphysema No psychiatric disease or other condition that would preclude study participation PRIOR CONCURRENT THERAPY: See Disease Characteristics No prior chemotherapy No prior or concurrent radiotherapy No concurrent prophylactic growth factors No concurrent biologic response modifiers
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Kenichi Sugihara, MD, PhD
Organizational Affiliation
Tokyo Medical and Dental University
Official's Role
Study Chair
Facility Information:
Facility Name
Aichi Medical University
City
Aichi-gun
State/Province
Aichi
ZIP/Postal Code
480-1100
Country
Japan
Facility Name
Japanese Red Cross Nagoya First Hospital
City
Nagoya-shi
State/Province
Aichi
ZIP/Postal Code
453-0046
Country
Japan
Facility Name
Nagoya City University Hospital
City
Nagoya-shi
State/Province
Aichi
ZIP/Postal Code
467-8602
Country
Japan
Facility Name
Nagoya Central Hospital
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
453-0801
Country
Japan
Facility Name
Nagoya Ekisaikai Hospital
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
454-8502
Country
Japan
Facility Name
Ban Buntane Houtokukai Hospital
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
454-8509
Country
Japan
Facility Name
West Medical Center Jouhoku Municipal Hospital
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
462-0033
Country
Japan
Facility Name
Aichi Cancer Center
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
464-8681
Country
Japan
Facility Name
Nagoya University Hospital
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
466-8550
Country
Japan
Facility Name
Nagoya University School of Medicine
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
466
Country
Japan
Facility Name
Nagoya Midori Municipal Hospital
City
Nagoya
State/Province
Aichi
Country
Japan
Facility Name
Aichi Cancer Center at Aichi Hospital
City
Okazaki
State/Province
Aichi
ZIP/Postal Code
444-0011
Country
Japan
Facility Name
National Hospital Organization Toyohashi Medical Center
City
Toyohashi
State/Province
Aichi
ZIP/Postal Code
440-0836
Country
Japan
Facility Name
Toyohashi Municipal Hospital
City
Toyohashi
State/Province
Aichi
ZIP/Postal Code
441-8570
Country
Japan
Facility Name
Koseiren Kamo Hospital
City
Toyota
State/Province
Aichi
ZIP/Postal Code
471-8505
Country
Japan
Facility Name
Yamamoto Kumiai General Hospital
City
Noshiro
State/Province
Akita
ZIP/Postal Code
016-0014
Country
Japan
Facility Name
Hiraka General Hospital
City
Yokote
State/Province
Akita
ZIP/Postal Code
013-8610
Country
Japan
Facility Name
Asahi General Hospital
City
Asahi-machi
State/Province
Chiba
ZIP/Postal Code
289-2511
Country
Japan
Facility Name
Teikyo University Chiba Medical Center
City
Ichihara
State/Province
Chiba
ZIP/Postal Code
299-0111
Country
Japan
Facility Name
Juntendo Urayasu Hospital
City
Urayasu-shi
State/Province
Chiba
ZIP/Postal Code
279-0021
Country
Japan
Facility Name
Shikoku Cancer Center
City
Matsuyama
State/Province
Ehime
ZIP/Postal Code
790-0007
Country
Japan
Facility Name
Sumitomo Besshi Hospital
City
Niihama
State/Province
Ehime
ZIP/Postal Code
792-0008
Country
Japan
Facility Name
Fukuiken Saiseikai Hospital
City
Fukui-shi
State/Province
Fukui
ZIP/Postal Code
918-8503
Country
Japan
Facility Name
University of Fukui Hospital
City
Yoshida-gun
State/Province
Fukui
ZIP/Postal Code
910-1193
Country
Japan
Facility Name
Kyushu University Hospital
City
Fukuoka-shi
State/Province
Fukuoka
ZIP/Postal Code
812-8582
Country
Japan
Facility Name
University of Occupational and Environmental Health
City
Kitakyushu-shi
State/Province
Fukuoka
ZIP/Postal Code
807-8555
Country
Japan
Facility Name
Kitakyushu Municipal Medical Center
City
Kitakyushu
State/Province
Fukuoka
ZIP/Postal Code
802-0077
Country
Japan
Facility Name
Kurume University School of Medicine
City
Kurume
State/Province
Fukuoka
ZIP/Postal Code
830-0011
Country
Japan
Facility Name
Saint Mary's Hospital
City
Kurume
State/Province
Fukuoka
ZIP/Postal Code
830-8543
Country
Japan
Facility Name
Social Insurance Tagawa Hospital
City
Tagawa
State/Province
Fukuoka
ZIP/Postal Code
826-8585
Country
Japan
Facility Name
Fukushima Medical University Hospital
City
Fukushima-shi
State/Province
Fukushima
ZIP/Postal Code
960-1295
Country
Japan
Facility Name
Gifu Municipal Hospital
City
Gifu-shi
State/Province
Gifu
ZIP/Postal Code
500-8323
Country
Japan
Facility Name
Hashima City Hospital
City
Hashima
State/Province
Gifu
ZIP/Postal Code
501-6206
Country
Japan
Facility Name
Ogaki Municipal Hospital
City
Ogaki-shi
State/Province
Gifu
ZIP/Postal Code
503-8502
Country
Japan
Facility Name
Gunma University Graduate School of Medicine
City
Maebashi-shi
State/Province
Gunma
ZIP/Postal Code
371-8511
Country
Japan
Facility Name
Gunma Cancer Center
City
Otashi
State/Province
Gunma
ZIP/Postal Code
373-8550
Country
Japan
Facility Name
National Hospital Organization Fukuyama Medical Center
City
Fukuyama
State/Province
Hiroshima
ZIP/Postal Code
720-0825
Country
Japan
Facility Name
Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers
City
Fukuyama
State/Province
Hiroshima
ZIP/Postal Code
721-8581
Country
Japan
Facility Name
National Hospital Organization Kure Medical Center
City
Kure
State/Province
Hiroshima
ZIP/Postal Code
737-0023
Country
Japan
Facility Name
Miyoshi Central Hospital
City
Miyoshi
State/Province
Hiroshima
ZIP/Postal Code
728-8502
Country
Japan
Facility Name
Asahikawa Medical College
City
Asahikawa
State/Province
Hokkaido
ZIP/Postal Code
078-8510
Country
Japan
Facility Name
Otaru Ekisaikai Hospital
City
Asahikawa
State/Province
Hokkaido
ZIP/Postal Code
078-8510
Country
Japan
Facility Name
Hakodate Goryoukaku Hospital
City
Hakodate
State/Province
Hokkaido
ZIP/Postal Code
040-8611
Country
Japan
Facility Name
Hirosaki University, School of Medicine
City
Otaru-shi
State/Province
Hokkaido
ZIP/Postal Code
047-0031
Country
Japan
Facility Name
Sapporo-Kosei General Hospital
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
060-0033
Country
Japan
Facility Name
Sapporo Medical University
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
060-8556
Country
Japan
Facility Name
Sapporo City General Hospital
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
060-8604
Country
Japan
Facility Name
Hokkaido University Graduate School of Medicine
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
060-8638
Country
Japan
Facility Name
Akashi Municipal Hospital
City
Akashi
State/Province
Hyogo
ZIP/Postal Code
673-8501
Country
Japan
Facility Name
Hyogo Cancer Center
City
Akashi
State/Province
Hyogo
ZIP/Postal Code
673-8558
Country
Japan
Facility Name
Ako City Hospital
City
Akou
State/Province
Hyogo
ZIP/Postal Code
678-0232
Country
Japan
Facility Name
Hyogo Prefectural Amagasaki Hospital
City
Amagasaki
State/Province
Hyogo
ZIP/Postal Code
660-0828
Country
Japan
Facility Name
Kansai Rosai Hospital
City
Amagasaki
State/Province
Hyogo
ZIP/Postal Code
660-8511
Country
Japan
Facility Name
Himeji St. Mary's Hospital
City
Himeji
State/Province
Hyogo
ZIP/Postal Code
670-0801
Country
Japan
Facility Name
Himeji Central Hospital
City
Himeji
State/Province
Hyogo
ZIP/Postal Code
672-8501
Country
Japan
Facility Name
Kinki Central Hospital
City
Itami
State/Province
Hyogo
Country
Japan
Facility Name
Kakogawa Municipal Hospital
City
Kakogawa
State/Province
Hyogo
ZIP/Postal Code
675-8611
Country
Japan
Facility Name
Kobe City General Hospital
City
Kobe-shi
State/Province
Hyogo
ZIP/Postal Code
650-0046
Country
Japan
Facility Name
Kobe University Hospital
City
Kobe
State/Province
Hyogo
ZIP/Postal Code
650-0017
Country
Japan
Facility Name
Shakai Hoken Kobe Central Hospital
City
Kobe
State/Province
Hyogo
ZIP/Postal Code
651-1145
Country
Japan
Facility Name
Nishi-Kobe Medical Center
City
Kobe
State/Province
Hyogo
ZIP/Postal Code
651-2273
Country
Japan
Facility Name
Kobe West City Hospital
City
Kobe
State/Province
Hyogo
ZIP/Postal Code
653-0013
Country
Japan
Facility Name
Kobe Medical Center
City
Kobe
State/Province
Hyogo
ZIP/Postal Code
654-0155
Country
Japan
Facility Name
Sano Hospital
City
Kobe
State/Province
Hyogo
ZIP/Postal Code
655-0031
Country
Japan
Facility Name
Hyogo College of Medicine
City
Nishinomiya
State/Province
Hyogo
ZIP/Postal Code
663-8501
Country
Japan
Facility Name
Hyogo Prefectural Awaji Hospital
City
Sumoto
State/Province
Hyogo
ZIP/Postal Code
656-0013
Country
Japan
Facility Name
Higashi Takarazuka Satoh Hospital
City
Takarazukai
State/Province
Hyogo
ZIP/Postal Code
665-0873
Country
Japan
Facility Name
Takarazuka Municipal Hospital
City
Takarazuka
State/Province
Hyogo
ZIP/Postal Code
665-0827
Country
Japan
Facility Name
Public Shiso General Hospital
City
Yamsakicho
State/Province
Hyogo
Country
Japan
Facility Name
Mito Saiseikai General Hospital
City
Mito
State/Province
Ibaraki
ZIP/Postal Code
311-4198
Country
Japan
Facility Name
Tsuchiura Kyodo General Hospital
City
Tsuchiura
State/Province
Ibaraki
ZIP/Postal Code
300-0053
Country
Japan
Facility Name
Kanazawa Medical University
City
Kahoku-gun
State/Province
Ishikawa
ZIP/Postal Code
920-0265
Country
Japan
Facility Name
Kanazawa University Hospital
City
Kanazawa
State/Province
Ishikawa
ZIP/Postal Code
920-8641
Country
Japan
Facility Name
Iwate Medical University Hospital
City
Morioka
State/Province
Iwate
ZIP/Postal Code
020-8505
Country
Japan
Facility Name
Iwate Prefectural Central Hospital
City
Morioka
State/Province
Iwate
ZIP/Postal Code
020-8505
Country
Japan
Facility Name
Kagawa Rosai Hospital
City
Marugame
State/Province
Kagawa
ZIP/Postal Code
763-8502
Country
Japan
Facility Name
Kagawa University Hospital
City
Miki
State/Province
Kagawa
ZIP/Postal Code
761-0793
Country
Japan
Facility Name
Kagawa Prefectural Central Hospital
City
Takamatsu
State/Province
Kagawa
ZIP/Postal Code
760-8557
Country
Japan
Facility Name
Kanagawa Prefectural Ashigawa-kami Hospital
City
Ashigarakami-gun
State/Province
Kanagawa
ZIP/Postal Code
258-0003
Country
Japan
Facility Name
Chigasaki Municipal Hospital
City
Chigasaki
State/Province
Kanagawa
ZIP/Postal Code
253-0083
Country
Japan
Facility Name
Fujisawa City Hospital
City
Fujisawa-shi
State/Province
Kanagawa
ZIP/Postal Code
251-8550
Country
Japan
Facility Name
Kanto Rosai Hospital
City
Kawasaki
State/Province
Kanagawa
ZIP/Postal Code
211-8510
Country
Japan
Facility Name
Nippon Medical School Musashikosugi Hospital
City
Kawasaki
State/Province
Kanagawa
ZIP/Postal Code
211-8533
Country
Japan
Facility Name
Saint Marianna University School of Medicine
City
Kawasaki
State/Province
Kanagawa
ZIP/Postal Code
216-8511
Country
Japan
Facility Name
Sagamihara National Hospital
City
Sagamihara
State/Province
Kanagawa
ZIP/Postal Code
228-8522
Country
Japan
Facility Name
Showa University Northern Yokohama Hospital
City
Yokohama-shi
State/Province
Kanagawa
ZIP/Postal Code
224-8503
Country
Japan
Facility Name
Showa University Fujigaoka Hospital
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
227-8502
Country
Japan
Facility Name
Social Insurance Yokohama Central Hospital
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
231-8553
Country
Japan
Facility Name
Yokohama City University Medical Center
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
232-0024
Country
Japan
Facility Name
Saiseikai Yokohama City Nanbu Hospital
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
234-8503
Country
Japan
Facility Name
Yokohama City Hospital
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
240
Country
Japan
Facility Name
St. Marianna University Yokohama City Seibu Hospital
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
241-0811
Country
Japan
Facility Name
Kanagawa Cancer Center
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
241-0815
Country
Japan
Facility Name
International Goodwill Hospital
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
245-0006
Country
Japan
Facility Name
Yokosuka Kyosai Hospital
City
Yokosuka
State/Province
Kanagawa
ZIP/Postal Code
238-8558
Country
Japan
Facility Name
Kochi Medical School
City
Nankoku
State/Province
Kochi
ZIP/Postal Code
783-8505
Country
Japan
Facility Name
National Hospital Organization - Kumamotominami Hospital
City
Uki
State/Province
Kumamoto
ZIP/Postal Code
869-0
Country
Japan
Facility Name
Japan Labor Health and Welfare Organization Kumamoto Rosai Hospital
City
Yashiro
State/Province
Kumamoto
ZIP/Postal Code
866-0826
Country
Japan
Facility Name
Yatsushiro Health Insurance General Hospital
City
Yatsushiro
State/Province
Kumamoto
ZIP/Postal Code
866-8660
Country
Japan
Facility Name
Kyoto First Red Cross Hospital
City
Higashiyama-ku
State/Province
Kyoto
ZIP/Postal Code
605-0981
Country
Japan
Facility Name
Kyoto Second Red Cross Hospital
City
Kanigyou-ku
State/Province
Kyoto
ZIP/Postal Code
602-8026
Country
Japan
Facility Name
Nantan General Hospital
City
Nantan
State/Province
Kyoto
ZIP/Postal Code
629-0197
Country
Japan
Facility Name
Kyoto University Hospital
City
Sakyo-ku
State/Province
Kyoto
ZIP/Postal Code
606-8507
Country
Japan
Facility Name
Mie University Graduate School of Medicine
City
Thu-shi
State/Province
Mie
ZIP/Postal Code
514-8507
Country
Japan
Facility Name
Miyagi Cancer Center
City
Natori-shi
State/Province
Miyagi
ZIP/Postal Code
981-1293
Country
Japan
Facility Name
Sendai Kousei Hospital
City
Sendai
State/Province
Miyagi
ZIP/Postal Code
980-0873
Country
Japan
Facility Name
Tohoku University Graduate School of Medicine
City
Sendai
State/Province
Miyagi
ZIP/Postal Code
980-8574
Country
Japan
Facility Name
Tohoku Rosai Hospital
City
Sendai
State/Province
Miyagi
ZIP/Postal Code
981-0911
Country
Japan
Facility Name
Sendai Medical Center
City
Sendai
State/Province
Miyagi
ZIP/Postal Code
983-8520
Country
Japan
Facility Name
Iida Municipal Hospital
City
Iida
State/Province
Nagano
ZIP/Postal Code
395-8502
Country
Japan
Facility Name
Showa-Inan General Hospital
City
Komagane
State/Province
Nagano
ZIP/Postal Code
399-4191
Country
Japan
Facility Name
Aizawa Hospital
City
Matsumoto
State/Province
Nagano
ZIP/Postal Code
390-8510
Country
Japan
Facility Name
Nagano Municipal Hospital
City
Nagano-shi
State/Province
Nagano
ZIP/Postal Code
381-8551
Country
Japan
Facility Name
Hokushin Hospital
City
Nakano
State/Province
Nagano
ZIP/Postal Code
383-0021
Country
Japan
Facility Name
Nagasaki University Hospital
City
Magasaki-shi
State/Province
Nagasaki
ZIP/Postal Code
852-8501
Country
Japan
Facility Name
Japanese Red Cross Nagasaki Genbaku Hospital
City
Nagasaki-shi
State/Province
Nagasaki
ZIP/Postal Code
852-8511
Country
Japan
Facility Name
National Hospital Organization Nagasaki Medical Center
City
Omura
State/Province
Nagasaki
ZIP/Postal Code
856-8562
Country
Japan
Facility Name
Sasebo City General Hospital
City
Sasebo-shi
State/Province
Nagasaki
ZIP/Postal Code
857-8511
Country
Japan
Facility Name
Nara Medical University Cancer Center
City
Kashihara
State/Province
Nara
ZIP/Postal Code
634-8522
Country
Japan
Facility Name
Kenseikai Nara Coloproctology Center
City
Yamatotakada
State/Province
Nara
ZIP/Postal Code
635-0022
Country
Japan
Facility Name
Nagaoka Chuo General Hospital
City
Nagaoka
State/Province
Niigata
ZIP/Postal Code
940-8653
Country
Japan
Facility Name
Niigata University Medical and Dental Hospital
City
Niigata-shi
State/Province
Niigata
ZIP/Postal Code
951-8122
Country
Japan
Facility Name
Niigata Cancer Center Hospital
City
Niigata-shi
State/Province
Niigata
ZIP/Postal Code
951-8566
Country
Japan
Facility Name
Oita University Hospital
City
Yufu-shi
State/Province
Oita
ZIP/Postal Code
879-5593
Country
Japan
Facility Name
Kawasaki Medical School
City
Kurashiki-shi
State/Province
Okayama
ZIP/Postal Code
701-0192
Country
Japan
Facility Name
Kurashiki Central Hospital
City
Kurashiki
State/Province
Okayama
ZIP/Postal Code
710-8602
Country
Japan
Facility Name
Hoshigaoka Koseinenkin Hospital
City
Hirakata
State/Province
Osaka
ZIP/Postal Code
573-8511
Country
Japan
Facility Name
Izumiotsu Municipal Hospital
City
Izumiotsu
State/Province
Osaka
ZIP/Postal Code
595
Country
Japan
Facility Name
Rinku General Medical Center
City
Izumisano
State/Province
Osaka
ZIP/Postal Code
598-8577
Country
Japan
Facility Name
Minoh City Hospital
City
Mino
State/Province
Osaka
ZIP/Postal Code
562-0014
Country
Japan
Facility Name
Kansai Medical University Takii Hospital
City
Moriguchi
State/Province
Osaka
ZIP/Postal Code
570-8507
Country
Japan
Facility Name
Osaka City General Hospital
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
534-0021
Country
Japan
Facility Name
Osaka Police Hospital
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
543-8502
Country
Japan
Facility Name
Osaka Kosei Nenkin Hospital
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
553-0003
Country
Japan
Facility Name
Osaka General Medical Center
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
558-8558
Country
Japan
Facility Name
Kinki University School of Medicine
City
Osakasayama
State/Province
Osaka
ZIP/Postal Code
589-8511
Country
Japan
Facility Name
Osaka Rosai Hospital
City
Sakai-shi
State/Province
Osaka
ZIP/Postal Code
591-8025
Country
Japan
Facility Name
Sakai Municipal Hospital
City
Sakai
State/Province
Osaka
ZIP/Postal Code
590-0064
Country
Japan
Facility Name
Bell Land General Hospital
City
Sakai
State/Province
Osaka
ZIP/Postal Code
599-8247
Country
Japan
Facility Name
Suita Municipal Hospital
City
Suita-shi
State/Province
Osaka
ZIP/Postal Code
564-0082
Country
Japan
Facility Name
Osaka Medical College
City
Takatsuki
State/Province
Osaka
ZIP/Postal Code
569-8686
Country
Japan
Facility Name
Saiseikai Tondabayashi Hospital
City
Tondabayashi
State/Province
Osaka
ZIP/Postal Code
584-0082
Country
Japan
Facility Name
Fukaya Red Cross Hospital
City
Fukaya
State/Province
Saitama
ZIP/Postal Code
366-0052
Country
Japan
Facility Name
Hasuda Hospital
City
Hasuda
State/Province
Saitama
ZIP/Postal Code
349-0123
Country
Japan
Facility Name
Saitama Medical University International Medical Center
City
Hidaka
State/Province
Saitama
ZIP/Postal Code
350-1241
Country
Japan
Facility Name
Saitama Medical School Hospital
City
Kawagoe-shi
State/Province
Saitama
ZIP/Postal Code
350-8550
Country
Japan
Facility Name
Kitasato Institute Medical Center Hospital
City
Kitamoto
State/Province
Saitama
ZIP/Postal Code
3648501
Country
Japan
Facility Name
Omiya Medical Center ofJichi Medical School
City
Saitamaken
State/Province
Saitama
ZIP/Postal Code
330-8503
Country
Japan
Facility Name
National Hospital Organization - Nishisaitama-Chuo National Hospital
City
Tokorozawa
State/Province
Saitama
ZIP/Postal Code
359-1151
Country
Japan
Facility Name
National Defense Medical College
City
Tokorozawa
State/Province
Saitama
ZIP/Postal Code
359-8513
Country
Japan
Facility Name
Shiga University of Medical Science
City
Otsu-shi
State/Province
Shiga
ZIP/Postal Code
520-2192
Country
Japan
Facility Name
Otsu Municipal Hospital
City
Otsu
State/Province
Shiga
ZIP/Postal Code
520-0804
Country
Japan
Facility Name
Shimane Prefectural Central Hospital
City
Izumo-shi
State/Province
Shimane
ZIP/Postal Code
693-0068
Country
Japan
Facility Name
Fujieda Municipal General Hospital
City
Fujieda
State/Province
Shizuoka
ZIP/Postal Code
426-8677
Country
Japan
Facility Name
Hamamatsu University School of Medicine
City
Hamamatsu-shi
State/Province
Shizuoka
ZIP/Postal Code
431-3192
Country
Japan
Facility Name
Shizuoka Cancer Center
City
Sunto-gun
State/Province
Shizuoka
ZIP/Postal Code
411-8777
Country
Japan
Facility Name
Yaizu Municipal Hospital
City
Yaizu
State/Province
Shizuoka
ZIP/Postal Code
425-8505
Country
Japan
Facility Name
Ohtawara Red Cross Hospital
City
Ohtawawa
State/Province
Tochigi
ZIP/Postal Code
324-0
Country
Japan
Facility Name
Dokkyo University School of Medicine
City
Shimotsuga-gun
State/Province
Tochigi
ZIP/Postal Code
321-0293
Country
Japan
Facility Name
Jichi Medical School
City
Shimotsuke-shi
State/Province
Tochigi
ZIP/Postal Code
329-0498
Country
Japan
Facility Name
Tochigi Cancer Center
City
Utsunomiya
State/Province
Tochigi
ZIP/Postal Code
320-0834
Country
Japan
Facility Name
Anan Kyoei Hospital
City
Anan
State/Province
Tokushima
ZIP/Postal Code
770-8503
Country
Japan
Facility Name
Juntendo University School of Medicine
City
Bunkyo-ku
State/Province
Tokyo
ZIP/Postal Code
113-0033
Country
Japan
Facility Name
St. Luke's International Hospital
City
Chuo-ku
State/Province
Tokyo
ZIP/Postal Code
104-8560
Country
Japan
Facility Name
Tokyo Metropolitan Fuchu Hospital
City
Fuchu
State/Province
Tokyo
ZIP/Postal Code
183-8524
Country
Japan
Facility Name
Higashiyamato General Hospital
City
Higashiyamato
State/Province
Tokyo
ZIP/Postal Code
207-0014
Country
Japan
Facility Name
Tokyo-Kita Social Insurance Hospital
City
Kita-ku
State/Province
Tokyo
ZIP/Postal Code
115-0053
Country
Japan
Facility Name
Showa General Hospital
City
Kodaira
State/Province
Tokyo
ZIP/Postal Code
187-8510
Country
Japan
Facility Name
Daisan Hospital
City
Komae
State/Province
Tokyo
ZIP/Postal Code
201
Country
Japan
Facility Name
Toho University Ohashi Hospital
City
Meguro-ku
State/Province
Tokyo
ZIP/Postal Code
153-8515
Country
Japan
Facility Name
Toranomon Hospital
City
Minato-ku
State/Province
Tokyo
ZIP/Postal Code
105-8470
Country
Japan
Facility Name
Kyorin University School of Medicine - Mitaka Campus
City
Mitaka
State/Province
Tokyo
ZIP/Postal Code
181-8611
Country
Japan
Facility Name
Nakano General Hospital
City
Nakano
State/Province
Tokyo
ZIP/Postal Code
164-8607
Country
Japan
Facility Name
Social Insurance Chuo General Hospital
City
Shinjuku-ku
State/Province
Tokyo
ZIP/Postal Code
169-0073
Country
Japan
Facility Name
Tokyo Women's Medical University
City
Shinjyuku-ku
State/Province
Tokyo
ZIP/Postal Code
162-8666
Country
Japan
Facility Name
Tottori University - Faculty of Medicine
City
Yonago
State/Province
Tottori
ZIP/Postal Code
683-8503
Country
Japan
Facility Name
Koseiren Takaoka Hospital
City
Takaoka-shi
State/Province
Toyama
ZIP/Postal Code
933-8555
Country
Japan
Facility Name
Toyama Prefectural Central Hospital
City
Toyama-shi
State/Province
Toyama
ZIP/Postal Code
930-8550
Country
Japan
Facility Name
Shingu Municipal Medical Center
City
Shingu
State/Province
Wakayama
ZIP/Postal Code
647-0072
Country
Japan
Facility Name
Social Insurance Kinan Hospital
City
Tanabe
State/Province
Wakayama
ZIP/Postal Code
646-8588
Country
Japan
Facility Name
Wakayama Medical University
City
Wakayama-shi
State/Province
Wakayama
ZIP/Postal Code
641-8509
Country
Japan
Facility Name
National Hospital Organization - Kanmon Medical Center
City
Shimonoseki
State/Province
Yamaguchi
ZIP/Postal Code
240-8555
Country
Japan
Facility Name
Shimonoseki Kosei Hospital
City
Shimonoseki
State/Province
Yamaguchi
ZIP/Postal Code
750-0061
Country
Japan
Facility Name
Yamaguchi University Graduate School of Medicine
City
Ube
State/Province
Yamaguchi
ZIP/Postal Code
755-8505
Country
Japan
Facility Name
University of Yamanashi Faculty of Medicine
City
Chu-o-shi
State/Province
Yamanashi
ZIP/Postal Code
409-3898
Country
Japan
Facility Name
Ageo Central General Hospital
City
Ageo
ZIP/Postal Code
362-8588
Country
Japan
Facility Name
Saiseikai Hiroshima Hospital
City
Aki-Gun
ZIP/Postal Code
731-4311
Country
Japan
Facility Name
Akita Kumiai General Hospital
City
Akita
ZIP/Postal Code
011-0948
Country
Japan
Facility Name
Aomori City Hospital
City
Aomori
ZIP/Postal Code
030-0821
Country
Japan
Facility Name
Chiba Cancer Center
City
Chiba
ZIP/Postal Code
260-8717
Country
Japan
Facility Name
Chiba University
City
Chiba
ZIP/Postal Code
260
Country
Japan
Facility Name
Northern Fukushima Medical Center
City
Date
ZIP/Postal Code
960-0502
Country
Japan
Facility Name
National Hospital Organization Kyushu Medical Center
City
Fukuoka
ZIP/Postal Code
810-0065
Country
Japan
Facility Name
National Kyushu Cancer Center
City
Fukuoka
ZIP/Postal Code
811-1395
Country
Japan
Facility Name
Matsunami General Hospital
City
Gifu
ZIP/Postal Code
501-6062
Country
Japan
Facility Name
Chugoku Electric Power Hospital
City
Hiroshima-shi
ZIP/Postal Code
730-8562
Country
Japan
Facility Name
Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital
City
Hiroshima
ZIP/Postal Code
730-8619
Country
Japan
Facility Name
Hiroshima Prefectural Hospital
City
Hiroshima
ZIP/Postal Code
734-8530
Country
Japan
Facility Name
Hiroshima University Hospital
City
Hiroshima
ZIP/Postal Code
734-8551
Country
Japan
Facility Name
National Hospital Organization Mito Medical Center
City
Ibaraki
ZIP/Postal Code
311-3193
Country
Japan
Facility Name
Hokkaido Chuo Rosai Hospital
City
Iwamizawa
ZIP/Postal Code
068-0004
Country
Japan
Facility Name
Nanpuh Hospital
City
Kagoshima
ZIP/Postal Code
892-8512
Country
Japan
Facility Name
Kitasato University School of Medicine
City
Kanagawa
ZIP/Postal Code
228-8555
Country
Japan
Facility Name
Osaka Minami Medical Center
City
Kawachinagano
ZIP/Postal Code
586-8521
Country
Japan
Facility Name
Kiryu Kosei General Hospital
City
Kiryu
ZIP/Postal Code
376-0024
Country
Japan
Facility Name
Kobe Ekisaikai Hospital
City
Kobe
ZIP/Postal Code
655-0004
Country
Japan
Facility Name
Kochi Health Sciences Center
City
Kochi
ZIP/Postal Code
781-8555
Country
Japan
Facility Name
Konan Kosei Hospital
City
Konan
ZIP/Postal Code
483-8704
Country
Japan
Facility Name
Southern TOHOKU research Institute for Neuroscience
City
Koriyama-city
ZIP/Postal Code
963-8563
Country
Japan
Facility Name
Kumamoto University Faculty of Medical and Pharmaceutical Sciences
City
Kumamoto
ZIP/Postal Code
860-8556
Country
Japan
Facility Name
Japanese Red Cross Kumamoto Hospital
City
Kumamoto
ZIP/Postal Code
861-8520
Country
Japan
Facility Name
Kyoto Prefectural University of Medicine
City
Kyoto
ZIP/Postal Code
602-0841
Country
Japan
Facility Name
Nishijin Hospital
City
Kyoto
ZIP/Postal Code
602
Country
Japan
Facility Name
National Hospital Organization - Kyoto Medical Center
City
Kyoto
ZIP/Postal Code
612-0861
Country
Japan
Facility Name
Kyoto-Katsura Hospital
City
Kyoto
ZIP/Postal Code
615-8256
Country
Japan
Facility Name
Saiseikai Matsusaka General Hospital
City
Matsusaka
ZIP/Postal Code
515-0004
Country
Japan
Facility Name
Muroran City General Hospital
City
Muroran
ZIP/Postal Code
051-8512
Country
Japan
Facility Name
Kyoritsu General Hospital
City
Nagoya
ZIP/Postal Code
456-8611
Country
Japan
Facility Name
Nakatsu Municipal Hospital
City
Nakatsu
ZIP/Postal Code
871-0011
Country
Japan
Facility Name
Saiseikai Nara Hospital
City
Nara
ZIP/Postal Code
6308145
Country
Japan
Facility Name
Nara Prefectual Nara Hospital
City
Nara
ZIP/Postal Code
631-0846
Country
Japan
Facility Name
Saiseikai Niigata Daini Hospital
City
Niigata
ZIP/Postal Code
950-1104
Country
Japan
Facility Name
Numazu City Hospital
City
Numazu, Shizuoka
ZIP/Postal Code
410-0302
Country
Japan
Facility Name
Oita Prefectural Hospital
City
Oita-shi
ZIP/Postal Code
870-8511
Country
Japan
Facility Name
Oita Red Cross Hospital
City
Oita
ZIP/Postal Code
870-0033
Country
Japan
Facility Name
Almeida Memorial Hospital
City
Oita
ZIP/Postal Code
870-1195
Country
Japan
Facility Name
Okayama University Medical School
City
Okayama
ZIP/Postal Code
700-8558
Country
Japan
Facility Name
Nakagami Hospital
City
Okinawa
ZIP/Postal Code
904-2195
Country
Japan
Facility Name
Kitano Hospital
City
Osaka
ZIP/Postal Code
530-8480
Country
Japan
Facility Name
Osaka City Juso Hospital
City
Osaka
ZIP/Postal Code
532-0
Country
Japan
Facility Name
Yodogawa Christian Hospital
City
Osaka
ZIP/Postal Code
533-0032
Country
Japan
Facility Name
Osaka Saiseikai Noe Hospital
City
Osaka
ZIP/Postal Code
536-0002
Country
Japan
Facility Name
Otemae Hospital
City
Osaka
ZIP/Postal Code
540-0008
Country
Japan
Facility Name
Osaka Red Cross Hospital
City
Osaka
ZIP/Postal Code
543-8555
Country
Japan
Facility Name
NTT West Osaka Hospital
City
Osaka
ZIP/Postal Code
543-8922
Country
Japan
Facility Name
Higashi Sumiyoshi Morimoto Hospital
City
Osaka
ZIP/Postal Code
546-0012
Country
Japan
Facility Name
Nissay Hospital
City
Osaka
ZIP/Postal Code
550-0012
Country
Japan
Facility Name
Minamiosaka Hospital
City
Osaka
Country
Japan
Facility Name
Saga Prefectural Hospital Koseikan
City
Saga
ZIP/Postal Code
840-8571
Country
Japan
Facility Name
Saitama Social Insurance Hospital
City
Saitama
ZIP/Postal Code
330-0074
Country
Japan
Facility Name
Hakodate Municipal Hospital
City
Sendai
ZIP/Postal Code
981-1103
Country
Japan
Facility Name
Miyagi Social Insurance Hospital
City
Sendai
ZIP/Postal Code
981-1103
Country
Japan
Facility Name
Japanese Red Cross Sendai Hospital
City
Sendai
ZIP/Postal Code
982-8501
Country
Japan
Facility Name
Shizuoka City Hospital
City
Shizuoka
ZIP/Postal Code
420 -8630
Country
Japan
Facility Name
Shizuoka Municipal Shimizu Hospital
City
Shizuoka
ZIP/Postal Code
424-0911
Country
Japan
Facility Name
Kawakita General Hospital
City
Suginami-ku
ZIP/Postal Code
166-8588
Country
Japan
Facility Name
Niigata Prefectural Tokamachi Hospital
City
Tokamachi
ZIP/Postal Code
948-0055
Country
Japan
Facility Name
Tokushima University Hospital
City
Tokushima
ZIP/Postal Code
770-8503
Country
Japan
Facility Name
Mita Hospital at the International University of Health and Welfare
City
Tokyo
ZIP/Postal Code
108-8329
Country
Japan
Facility Name
Tokyo Medical and Dental University
City
Tokyo
ZIP/Postal Code
113-8519
Country
Japan
Facility Name
Nippon Medical School
City
Tokyo
ZIP/Postal Code
113-8603
Country
Japan
Facility Name
Tokyo Metropolitan - Komagome Hospital
City
Tokyo
ZIP/Postal Code
113-8677
Country
Japan
Facility Name
Tokyo Women's Medical University Medical Center East
City
Tokyo
ZIP/Postal Code
116-8567
Country
Japan
Facility Name
Metropolitan Bokutoh Hospital
City
Tokyo
ZIP/Postal Code
130-8575
Country
Japan
Facility Name
Showa University Toyosu Hospital
City
Tokyo
ZIP/Postal Code
135-8577
Country
Japan
Facility Name
NTT Kanto Medical Center
City
Tokyo
ZIP/Postal Code
141-8625
Country
Japan
Facility Name
Toho University School of Medicine
City
Tokyo
ZIP/Postal Code
143-8541
Country
Japan
Facility Name
Japanese Red Cross Medical Center
City
Tokyo
ZIP/Postal Code
150-8935
Country
Japan
Facility Name
National Hospital Organization - Tokyo Medical Center
City
Tokyo
ZIP/Postal Code
152-0021
Country
Japan
Facility Name
International Medical Center of Japan
City
Tokyo
ZIP/Postal Code
162-8655
Country
Japan
Facility Name
Teikyo University School of Medicine
City
Tokyo
ZIP/Postal Code
173-8605
Country
Japan
Facility Name
Jikei University School of Medicine Hospital
City
Tokyo
ZIP/Postal Code
25-8506
Country
Japan
Facility Name
Takasago Kyoritsu Hospital
City
Tokyo
Country
Japan
Facility Name
Toyama Red Cross Hospital
City
Toyama
ZIP/Postal Code
930-0859
Country
Japan
Facility Name
Japanese Red Cross Society
City
Wakayama
ZIP/Postal Code
640-8269
Country
Japan
Facility Name
Japan Labor Health and Welfare Organization Wakayama Rosai Hospital
City
Wakayama
ZIP/Postal Code
640-8435
Country
Japan
Facility Name
Yamagata Prefectural Central Hospital
City
Yamagata
ZIP/Postal Code
990-2292
Country
Japan
Facility Name
Yamagata Saisei Hospital
City
Yamagata
ZIP/Postal Code
990-8545
Country
Japan
Facility Name
Yamagata University Hospital
City
Yamagata
ZIP/Postal Code
990-9585
Country
Japan
Facility Name
Saiseikai Yokohamashi Tobu Hospital
City
Yokohama
ZIP/Postal Code
230-0012
Country
Japan
Facility Name
Yokohama City Minato Red Cross Hospital
City
Yokohama
ZIP/Postal Code
231-8682
Country
Japan
Facility Name
Hitachi Yokohama Hospital
City
Yokohama
ZIP/Postal Code
244-0003
Country
Japan

12. IPD Sharing Statement

Citations:
PubMed Identifier
31180819
Citation
Ueno H, Ishiguro M, Nakatani E, Ishikawa T, Uetake H, Matsuda C, Nakamoto Y, Kotake M, Kurachi K, Egawa T, Yasumasa K, Murata K, Ikawa O, Shinji S, Murotani K, Matsui S, Teramukai S, Tomita N, Sugihara K; SACURA Study Group. Prospective Multicenter Study on the Prognostic and Predictive Impact of Tumor Budding in Stage II Colon Cancer: Results From the SACURA Trial. J Clin Oncol. 2019 Aug 1;37(22):1886-1894. doi: 10.1200/JCO.18.02059. Epub 2019 Jun 10.
Results Reference
derived
PubMed Identifier
29677641
Citation
Matsuda C, Ishiguro M, Teramukai S, Kajiwara Y, Fujii S, Kinugasa Y, Nakamoto Y, Kotake M, Sakamoto Y, Kurachi K, Maeda A, Komori K, Tomita N, Shimada Y, Takahashi K, Kotake K, Watanabe M, Mochizuki H, Nakagawa Y, Sugihara K; SACURA Study Group. A randomised-controlled trial of 1-year adjuvant chemotherapy with oral tegafur-uracil versus surgery alone in stage II colon cancer: SACURA trial. Eur J Cancer. 2018 Jun;96:54-63. doi: 10.1016/j.ejca.2018.03.009. Epub 2018 Apr 17.
Results Reference
derived
PubMed Identifier
22769569
Citation
Ishiguro M, Mochizuki H, Tomita N, Shimada Y, Takahashi K, Kotake K, Watanabe M, Kanemitsu Y, Ueno H, Ishikawa T, Uetake H, Matsui S, Teramukai S, Sugihara K. Study protocol of the SACURA trial: a randomized phase III trial of efficacy and safety of UFT as adjuvant chemotherapy for stage II colon cancer. BMC Cancer. 2012 Jul 7;12:281. doi: 10.1186/1471-2407-12-281.
Results Reference
derived

Learn more about this trial

Tegafur-Uracil or Observation in Treating Patients With Stage II Colorectal Cancer That Has Been Completely Removed By Surgery

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