search
Back to results

A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Stage 2B or 3 Locally Advanced, Colon Cancer

Primary Purpose

Colon Cancer

Status
Completed
Phase
Phase 2
Locations
Study Type
Interventional
Intervention
palifermin
placebo
Sponsored by
Amgen
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional supportive care trial for Colon Cancer focused on measuring KGF, Palifermin, Oral Mucositis, Clinical Trial, Amgen, Oncology, Colon Cancer

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • History of newly diagnosed histologically confirmed resected colon cancer (American Joint Committee on Cancer [AJCC] Stage 2B or 3) and a candidate for adjuvant 5-FU and Leucovorin
  • Eastern Cooperative Oncology Group performance status ≤ 1
  • Functional hematopoietic and hepato-renal systems

Exclusion Criteria:

  • Previous therapy (e.g. chemotherapy, radiotherapy or biological therapy) for colon cancer, other than surgical tumor resection
  • Presence or history of any other primary malignancy
  • Presence of active or chronic oral mucositis or xerostomia
  • Previous treatment with other keratinocyte growth factors

Sites / Locations

    Arms of the Study

    Arm 1

    Arm 2

    Arm Type

    Experimental

    Placebo Comparator

    Arm Label

    Palifermin

    Control Group

    Arm Description

    50 subjects to receive palifermin 3 days prior to the first day (day 1) of each cycle of 5-FU/ LV chemotherapy.

    50 subjects to receive matched placebo 3 days prior to the first day (day 1) of each cycle of 5-FU/ LV chemotherapy.

    Outcomes

    Primary Outcome Measures

    Incidence of Grade ≥ 2 (WHO scale) oral mucositis

    Secondary Outcome Measures

    Incidence of chemotherapy (5-FU) dose reductions and dose delays
    Average mouth and throat soreness (MTS) score
    Duration of grade ≥ 2 (WHO scale) oral mucositis
    Incidence and severity of adverse events
    Changes in laboratory values
    Incidence of serum anti-palifermin antibody formation
    Progressive disease rate
    Incidence of secondary primary tumors
    Incidence of other malignancies
    Progression-free survival (PFS)
    Overall survival (OS)
    Incidence of grade ≥ 2 (WHO scale) oral mucositis

    Full Information

    First Posted
    October 26, 2006
    Last Updated
    July 14, 2014
    Sponsor
    Amgen
    search

    1. Study Identification

    Unique Protocol Identification Number
    NCT00393822
    Brief Title
    A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Stage 2B or 3 Locally Advanced, Colon Cancer
    Official Title
    A Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Palifermin (Recombinant Human Keratinocyte Growth Factor) for Reduction of Oral Mucositis in Subjects With Stage 2B or 3 Locally Advanced, Colon Cancer Receiving 5-FU and Leucovorin as Adjuvant Therapy
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    July 2014
    Overall Recruitment Status
    Completed
    Study Start Date
    August 2005 (undefined)
    Primary Completion Date
    December 2007 (Actual)
    Study Completion Date
    March 2014 (Actual)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Sponsor
    Name of the Sponsor
    Amgen

    4. Oversight

    Data Monitoring Committee
    No

    5. Study Description

    Brief Summary
    The purpose of this study is to evaluate the efficacy, safety, and tolerability of palifermin (recombinant human keratinocyte growth factor, rHuKGF) in reducing the incidence of oral mucositis in subjects with stage 2B and 3 locally advanced, colon cancer receiving chemotherapy as an adjuvant treatment for their disease.
    Detailed Description
    This study is being conducted to determine whether administration of a single IV dose of palifermin 3 days before initiation of chemotherapy and 3 days before each subsequent treatment cycle would reduce the incidence of oral mucositis and to evaluate the safety profile in the subject population. This study will evaluate the efficacy of palifermin in reducing the incidence of grade ≥ 2 OM in subjects with stage 2B or stage 3 locally advanced, colon cancer undergoing adjuvant chemotherapy with 5-FU and leucovorin in cycle 1. This study will also assess the safety and tolerability of palifermin administered as a single IV dose before each cycle of 5-FU and leucovorin, evaluate the effect of palifermin on patient-reported mouth and throat soreness, the incidence of grade ≥ 2 oral mucositis in cycle 2, the duration of grade ≥ 2 oral mucositis, 5-FU dose reductions/delays and the long-term effects of palifermin on disease outcome and survival.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Colon Cancer
    Keywords
    KGF, Palifermin, Oral Mucositis, Clinical Trial, Amgen, Oncology, Colon Cancer

    7. Study Design

    Primary Purpose
    Supportive Care
    Study Phase
    Phase 2, Phase 3
    Interventional Study Model
    Parallel Assignment
    Masking
    ParticipantCare ProviderInvestigatorOutcomes Assessor
    Allocation
    Randomized
    Enrollment
    100 (Actual)

    8. Arms, Groups, and Interventions

    Arm Title
    Palifermin
    Arm Type
    Experimental
    Arm Description
    50 subjects to receive palifermin 3 days prior to the first day (day 1) of each cycle of 5-FU/ LV chemotherapy.
    Arm Title
    Control Group
    Arm Type
    Placebo Comparator
    Arm Description
    50 subjects to receive matched placebo 3 days prior to the first day (day 1) of each cycle of 5-FU/ LV chemotherapy.
    Intervention Type
    Drug
    Intervention Name(s)
    palifermin
    Other Intervention Name(s)
    KGF
    Intervention Description
    dose of 120 μg/kg, intravenous (IV) on day -3 for each cycle, for up to 6 chemotherapy cycles
    Intervention Type
    Drug
    Intervention Name(s)
    placebo
    Other Intervention Name(s)
    Pbo
    Intervention Description
    one bolus IV injection at 120 μg/kg/day of matched placebo
    Primary Outcome Measure Information:
    Title
    Incidence of Grade ≥ 2 (WHO scale) oral mucositis
    Time Frame
    in Cycle 1 of chemotherapy treatment phase
    Secondary Outcome Measure Information:
    Title
    Incidence of chemotherapy (5-FU) dose reductions and dose delays
    Time Frame
    in Cycle 2 of chemotherapy treatment phase
    Title
    Average mouth and throat soreness (MTS) score
    Time Frame
    in Cycle 1 and in Cycle 2 of chemotherapy treatment phase
    Title
    Duration of grade ≥ 2 (WHO scale) oral mucositis
    Time Frame
    in Cycle 1 and in Cycle 2 of chemotherapy treatment phase
    Title
    Incidence and severity of adverse events
    Time Frame
    during Treatment Phase (6 cycles of chemotherapy)
    Title
    Changes in laboratory values
    Time Frame
    during Treatment Phase (6 cycles of chemotherapy)
    Title
    Incidence of serum anti-palifermin antibody formation
    Time Frame
    during Treatment Phase (6 cycles of chemotherapy)
    Title
    Progressive disease rate
    Time Frame
    at 6 months
    Title
    Incidence of secondary primary tumors
    Time Frame
    within long-term follow-up phase
    Title
    Incidence of other malignancies
    Time Frame
    within long-term follow-up phase
    Title
    Progression-free survival (PFS)
    Time Frame
    within long-term follow-up phase
    Title
    Overall survival (OS)
    Time Frame
    within long-term follow-up phase
    Title
    Incidence of grade ≥ 2 (WHO scale) oral mucositis
    Time Frame
    in Cycle 2 of chemotherapy treatment phase

    10. Eligibility

    Sex
    All
    Minimum Age & Unit of Time
    18 Years
    Accepts Healthy Volunteers
    No
    Eligibility Criteria
    Inclusion Criteria: History of newly diagnosed histologically confirmed resected colon cancer (American Joint Committee on Cancer [AJCC] Stage 2B or 3) and a candidate for adjuvant 5-FU and Leucovorin Eastern Cooperative Oncology Group performance status ≤ 1 Functional hematopoietic and hepato-renal systems Exclusion Criteria: Previous therapy (e.g. chemotherapy, radiotherapy or biological therapy) for colon cancer, other than surgical tumor resection Presence or history of any other primary malignancy Presence of active or chronic oral mucositis or xerostomia Previous treatment with other keratinocyte growth factors
    Overall Study Officials:
    First Name & Middle Initial & Last Name & Degree
    MD
    Organizational Affiliation
    Amgen
    Official's Role
    Study Director

    12. IPD Sharing Statement

    Links:
    URL
    http://download.veritasmedicine.com/REGFILES/amgen/Amgen_results_disclaimer.pdf
    Description
    Notice regarding posted summaries of trial results
    URL
    http://download.veritasmedicine.com/REGFILES/amgen/08D_FDAMA_113_Posting_Summary_24_KGF_20040122.pdf
    Description
    To access clinical trial results information click on this link
    URL
    http://www.amgentrials.com
    Description
    AmgenTrials clinical trials website

    Learn more about this trial

    A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Stage 2B or 3 Locally Advanced, Colon Cancer

    We'll reach out to this number within 24 hrs