A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Stage 2B or 3 Locally Advanced, Colon Cancer
Primary Purpose
Colon Cancer
Status
Completed
Phase
Phase 2
Locations
Study Type
Interventional
Intervention
palifermin
placebo
Sponsored by
About this trial
This is an interventional supportive care trial for Colon Cancer focused on measuring KGF, Palifermin, Oral Mucositis, Clinical Trial, Amgen, Oncology, Colon Cancer
Eligibility Criteria
Inclusion Criteria:
- History of newly diagnosed histologically confirmed resected colon cancer (American Joint Committee on Cancer [AJCC] Stage 2B or 3) and a candidate for adjuvant 5-FU and Leucovorin
- Eastern Cooperative Oncology Group performance status ≤ 1
- Functional hematopoietic and hepato-renal systems
Exclusion Criteria:
- Previous therapy (e.g. chemotherapy, radiotherapy or biological therapy) for colon cancer, other than surgical tumor resection
- Presence or history of any other primary malignancy
- Presence of active or chronic oral mucositis or xerostomia
- Previous treatment with other keratinocyte growth factors
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Placebo Comparator
Arm Label
Palifermin
Control Group
Arm Description
50 subjects to receive palifermin 3 days prior to the first day (day 1) of each cycle of 5-FU/ LV chemotherapy.
50 subjects to receive matched placebo 3 days prior to the first day (day 1) of each cycle of 5-FU/ LV chemotherapy.
Outcomes
Primary Outcome Measures
Incidence of Grade ≥ 2 (WHO scale) oral mucositis
Secondary Outcome Measures
Incidence of chemotherapy (5-FU) dose reductions and dose delays
Average mouth and throat soreness (MTS) score
Duration of grade ≥ 2 (WHO scale) oral mucositis
Incidence and severity of adverse events
Changes in laboratory values
Incidence of serum anti-palifermin antibody formation
Progressive disease rate
Incidence of secondary primary tumors
Incidence of other malignancies
Progression-free survival (PFS)
Overall survival (OS)
Incidence of grade ≥ 2 (WHO scale) oral mucositis
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT00393822
Brief Title
A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Stage 2B or 3 Locally Advanced, Colon Cancer
Official Title
A Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Palifermin (Recombinant Human Keratinocyte Growth Factor) for Reduction of Oral Mucositis in Subjects With Stage 2B or 3 Locally Advanced, Colon Cancer Receiving 5-FU and Leucovorin as Adjuvant Therapy
Study Type
Interventional
2. Study Status
Record Verification Date
July 2014
Overall Recruitment Status
Completed
Study Start Date
August 2005 (undefined)
Primary Completion Date
December 2007 (Actual)
Study Completion Date
March 2014 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Amgen
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
The purpose of this study is to evaluate the efficacy, safety, and tolerability of palifermin (recombinant human keratinocyte growth factor, rHuKGF) in reducing the incidence of oral mucositis in subjects with stage 2B and 3 locally advanced, colon cancer receiving chemotherapy as an adjuvant treatment for their disease.
Detailed Description
This study is being conducted to determine whether administration of a single IV dose of palifermin 3 days before initiation of chemotherapy and 3 days before each subsequent treatment cycle would reduce the incidence of oral mucositis and to evaluate the safety profile in the subject population. This study will evaluate the efficacy of palifermin in reducing the incidence of grade ≥ 2 OM in subjects with stage 2B or stage 3 locally advanced, colon cancer undergoing adjuvant chemotherapy with 5-FU and leucovorin in cycle 1. This study will also assess the safety and tolerability of palifermin administered as a single IV dose before each cycle of 5-FU and leucovorin, evaluate the effect of palifermin on patient-reported mouth and throat soreness, the incidence of grade ≥ 2 oral mucositis in cycle 2, the duration of grade ≥ 2 oral mucositis, 5-FU dose reductions/delays and the long-term effects of palifermin on disease outcome and survival.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Colon Cancer
Keywords
KGF, Palifermin, Oral Mucositis, Clinical Trial, Amgen, Oncology, Colon Cancer
7. Study Design
Primary Purpose
Supportive Care
Study Phase
Phase 2, Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
100 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Palifermin
Arm Type
Experimental
Arm Description
50 subjects to receive palifermin 3 days prior to the first day (day 1) of each cycle of 5-FU/ LV chemotherapy.
Arm Title
Control Group
Arm Type
Placebo Comparator
Arm Description
50 subjects to receive matched placebo 3 days prior to the first day (day 1) of each cycle of 5-FU/ LV chemotherapy.
Intervention Type
Drug
Intervention Name(s)
palifermin
Other Intervention Name(s)
KGF
Intervention Description
dose of 120 μg/kg, intravenous (IV) on day -3 for each cycle, for up to 6 chemotherapy cycles
Intervention Type
Drug
Intervention Name(s)
placebo
Other Intervention Name(s)
Pbo
Intervention Description
one bolus IV injection at 120 μg/kg/day of matched placebo
Primary Outcome Measure Information:
Title
Incidence of Grade ≥ 2 (WHO scale) oral mucositis
Time Frame
in Cycle 1 of chemotherapy treatment phase
Secondary Outcome Measure Information:
Title
Incidence of chemotherapy (5-FU) dose reductions and dose delays
Time Frame
in Cycle 2 of chemotherapy treatment phase
Title
Average mouth and throat soreness (MTS) score
Time Frame
in Cycle 1 and in Cycle 2 of chemotherapy treatment phase
Title
Duration of grade ≥ 2 (WHO scale) oral mucositis
Time Frame
in Cycle 1 and in Cycle 2 of chemotherapy treatment phase
Title
Incidence and severity of adverse events
Time Frame
during Treatment Phase (6 cycles of chemotherapy)
Title
Changes in laboratory values
Time Frame
during Treatment Phase (6 cycles of chemotherapy)
Title
Incidence of serum anti-palifermin antibody formation
Time Frame
during Treatment Phase (6 cycles of chemotherapy)
Title
Progressive disease rate
Time Frame
at 6 months
Title
Incidence of secondary primary tumors
Time Frame
within long-term follow-up phase
Title
Incidence of other malignancies
Time Frame
within long-term follow-up phase
Title
Progression-free survival (PFS)
Time Frame
within long-term follow-up phase
Title
Overall survival (OS)
Time Frame
within long-term follow-up phase
Title
Incidence of grade ≥ 2 (WHO scale) oral mucositis
Time Frame
in Cycle 2 of chemotherapy treatment phase
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
History of newly diagnosed histologically confirmed resected colon cancer (American Joint Committee on Cancer [AJCC] Stage 2B or 3) and a candidate for adjuvant 5-FU and Leucovorin
Eastern Cooperative Oncology Group performance status ≤ 1
Functional hematopoietic and hepato-renal systems
Exclusion Criteria:
Previous therapy (e.g. chemotherapy, radiotherapy or biological therapy) for colon cancer, other than surgical tumor resection
Presence or history of any other primary malignancy
Presence of active or chronic oral mucositis or xerostomia
Previous treatment with other keratinocyte growth factors
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
MD
Organizational Affiliation
Amgen
Official's Role
Study Director
12. IPD Sharing Statement
Links:
URL
http://download.veritasmedicine.com/REGFILES/amgen/Amgen_results_disclaimer.pdf
Description
Notice regarding posted summaries of trial results
URL
http://download.veritasmedicine.com/REGFILES/amgen/08D_FDAMA_113_Posting_Summary_24_KGF_20040122.pdf
Description
To access clinical trial results information click on this link
URL
http://www.amgentrials.com
Description
AmgenTrials clinical trials website
Learn more about this trial
A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Stage 2B or 3 Locally Advanced, Colon Cancer
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