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Effects of Peritendinous Corticosteroid Injections, Eccentric Training and Heavy Slow Resistance Training in Patellar Tendinopathy

Primary Purpose

Patellar Tendinopathy / Jumpers Knee

Status
Completed
Phase
Not Applicable
Locations
Denmark
Study Type
Interventional
Intervention
peritendinous corticosteroid injections
eccentric decline squat training
heavy slow resistance training
Sponsored by
Bispebjerg Hospital
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Patellar Tendinopathy / Jumpers Knee

Eligibility Criteria

18 Years - 55 Years (Adult)MaleDoes not accept healthy volunteers

Inclusion Criteria:

  • Clinical patellar tendinopathy pain.
  • Tendon swelling
  • Hypoechoic
  • Doppler activity in tendon

Exclusion Criteria:

  • Previous knee surgery
  • diabetes
  • arthritis
  • previous steroid injections

Sites / Locations

  • Institute of Sports Medicine Copenhagen. Dept 8 1st floor. Bispebjerg Hospital

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Active Comparator

Experimental

Experimental

Arm Label

CORT

ECC

HSR

Arm Description

Peritendinous corticosteroid injections at 0 and 4 weeks. 12 weeks total

12 weeks of eccentric unilateral decline squats

Heavy slow resistance training. 3/week. 12 weeks

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
November 27, 2006
Last Updated
May 21, 2008
Sponsor
Bispebjerg Hospital
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1. Study Identification

Unique Protocol Identification Number
NCT00404469
Brief Title
Effects of Peritendinous Corticosteroid Injections, Eccentric Training and Heavy Slow Resistance Training in Patellar Tendinopathy
Official Title
Effects of Peritendinous Corticosteroid Injections, Eccentric Training and Heavy Slow Resistance Training in Patellar Tendinopathy
Study Type
Interventional

2. Study Status

Record Verification Date
May 2008
Overall Recruitment Status
Completed
Study Start Date
March 2006 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
November 2007 (Actual)

3. Sponsor/Collaborators

Name of the Sponsor
Bispebjerg Hospital

4. Oversight

5. Study Description

Brief Summary
We will investigate the effect of peritendinous corticosteroid injections, eccentric training and heavy resistance training in male patellar tendinopathy patients. The purpose is to compare the clinical effect of these three treatments in a randomised controlled trial. Also we wish to investigate the treatment mechanisms responsible for the effectiveness of the three treatments.
Detailed Description
3 interventions groups as described above (n=13 in each group) 12 weeks intervention period. Clinical assessments before and after intervention: VAS, VISA, Tendon thickness, Doppler us activity. Before and after intervention tendon biopsies will be taken and analyzed for crosslinks and fibril diameter. Also tendon mechanical properties will be measured. Tendon and muscle structural properties will be measured with MRI. Treatment satisfaction will be stated after intervention period.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Patellar Tendinopathy / Jumpers Knee

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Investigator
Allocation
Randomized
Enrollment
39 (Actual)

8. Arms, Groups, and Interventions

Arm Title
CORT
Arm Type
Active Comparator
Arm Description
Peritendinous corticosteroid injections at 0 and 4 weeks. 12 weeks total
Arm Title
ECC
Arm Type
Experimental
Arm Description
12 weeks of eccentric unilateral decline squats
Arm Title
HSR
Arm Type
Experimental
Arm Description
Heavy slow resistance training. 3/week. 12 weeks
Intervention Type
Procedure
Intervention Name(s)
peritendinous corticosteroid injections
Intervention Description
1 ml of40mg/ml methylprednisolone acetate at 0 and 4 weeks. 2 week observational
Intervention Type
Procedure
Intervention Name(s)
eccentric decline squat training
Intervention Description
eccentric decline unilateral squats performed twice daily. for 12 weeks
Intervention Type
Procedure
Intervention Name(s)
heavy slow resistance training
Intervention Description
Heavy slow resistance training for knee extensors. 3/week. total of 12 weeks

10. Eligibility

Sex
Male
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
55 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Clinical patellar tendinopathy pain. Tendon swelling Hypoechoic Doppler activity in tendon Exclusion Criteria: Previous knee surgery diabetes arthritis previous steroid injections
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Mads Kongsgaard, PhD., MSc.
Organizational Affiliation
Institute of Sports Medicine, Copenhagen
Official's Role
Principal Investigator
Facility Information:
Facility Name
Institute of Sports Medicine Copenhagen. Dept 8 1st floor. Bispebjerg Hospital
City
Copenhagen
ZIP/Postal Code
2400
Country
Denmark

12. IPD Sharing Statement

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Effects of Peritendinous Corticosteroid Injections, Eccentric Training and Heavy Slow Resistance Training in Patellar Tendinopathy

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