The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney Disease
Polycystic Kidney, Autosomal Dominant
About this trial
This is an interventional other trial for Polycystic Kidney, Autosomal Dominant focused on measuring ADPKD, Urinary Aquaporin-2, ENaC, Fractional sodium excretion, High/low sodium diet
Eligibility Criteria
Inclusion Criteria:
- Caucasian men and women
- age 18-65 years
- BMI between 18,5-30,0 kg/m2
ADPKD, diagnosed by the following findings on ultra scan:
- for patients without ADPKD family history: > 5 bilateral cysts
- for patients with ADPKD family history: < 30 years: 2 cysts (unilateral or bilateral) 30-60 years: 2 or more bilateral cysts > 60 years: 4 or more bilateral cysts
- Kidney function: stadium 1-4.
Exclusion Criteria:
- Other kidney disease
- Anamnestic or clinical signs of acute myocardial infarction, atrial fibrillation, heart valve disease or chronic heart failure
- Anamnestic or clinical signs of disease in lungs, liver,endocrine organs or brain or neoplastic disease
- Family history of rupture of intracerebral aneurisms
- Alcohol or drug abuse
- Smoking
- Medical treatment arat form antihypertensives and oral anticonceptives
- Pregnancy or breastfeeding
Sites / Locations
- Department of Medical Research, Holstebro Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Other
Other
Other
Other
Patients with ADPKD, HS
Patients with ADPKD, LS
Healthy Control Subjects, HS
Healthy Control Subjects, LS
Each subject was studied on 2 separate days at least 3 weeks apart. During 4 days before the study day, the subjects consumed either a high sodium diet or a low sodium diet in randomized order (HS-LS/ LS-HS). On the study day a hypertonic saline infusion was given.
Each subject was studied on 2 separate days at least 3 weeks apart. During 4 days before the study day, the subjects consumed either a high sodium diet or a low sodium diet in randomized order (HS-LS/ LS-HS). On the study day a hypertonic saline infusion was given.
Each subject was studied on 2 separate days at least 3 weeks apart. During 4 days before the study day, the subjects consumed either a high sodium diet or a low sodium diet in randomized order (HS-LS/ LS-HS). On the study day a hypertonic saline infusion was given.
Each subject was studied on 2 separate days at least 3 weeks apart. During 4 days before the study day, the subjects consumed either a high sodium diet or a low sodium diet in randomized order (HS-LS/ LS-HS). On the study day a hypertonic saline infusion was given.